ENgineered CArtilage from Nose for the Treatment of Osteoarthritis (ENCANTO)

Información del proyecto

ENCANTO

Identificador del acuerdo de subvención: 101137315

DOI

10.3030/101137315

Fecha de la firma de la CE 11 Diciembre 2023

Fecha de inicio 1 Enero 2024

Fecha de finalización 31 Diciembre 2029

Financiado con arreglo a

• Health

Coste total

€ 8 363 555,00

Aportación de la UE

€ 8 363 555,00

Coordinado por

FONDAZIONE POLICLINICO UNIVERSITARIO CAMPUS BIO MEDICO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (2)

Definition and implementation of digital rehabilitation program and monitoring

Defined rehabilitation program with corresponding videos and detailed instructions in all languages implemented in the online platform. Digital monitoring and data acquisitionimplemented in the rehabilitation protocol on four levels: 1) ability to perform a specific task within dailyprotocol, 2) VAS pain score on daily basis, 3) traffic light system and 4)Bassett patient self-report scales for elapsed rehabilitation week.

Dissemination and Communication Plan first version

Dissemination and Communication plan report

Websites, patent fillings, videos etc. (1)

Project Website

The public website of the project.

Publicaciones

Peer reviewed articles (14)

Looking Inwards: The Role of Self‐Care, Self‐Management and Self‐Healing in Musculoskeletal Pain

Autores: Joyce McSwan, Catherine E. Panwar, Ali Mobasheri
Publicado en: Musculoskeletal Care, Edición 23, 2025, ISSN 1478-2189
Editor: Wiley
DOI: 10.1002/MSC.70169

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Autores: Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Publicado en: Osteoarthritis and Cartilage Open, Edición 7, 2025, ISSN 2665-9131
Editor: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis

Autores: Paco Mattheus Jacobus Welsing, Said el Bouhaddani, Lin Zhu, Nienke C. Nijhof, Simon C. Mastbergen, Chunyi Wen, Jaume Bacardit, Cristina Ruiz-Romero, Francisco J. Blanco, Ali Mobasheri
Publicado en: Connective Tissue Research, Edición 66, 2026, ISSN 0300-8207
Editor: Informa UK Limited
DOI: 10.1080/03008207.2025.2541291

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Autores: Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Publicado en: Osteoarthritis and Cartilage Open, Edición 7, 2025, ISSN 2665-9131
Editor: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Bone health and pregnancy: Osteoporosis and beyond

Autores: Ali Mobasheri, Jean-Yves Reginster, Manju Chandran, Joyce McSwan
Publicado en: Case Reports in Women's Health, Edición 47, 2025, ISSN 2214-9112
Editor: Elsevier BV
DOI: 10.1016/J.CRWH.2025.E00725

Insights into chondrocyte populations in cartilaginous tissues at the single-cell level

Autores: Csaba Matta, Roland Takács, Mona Dvir-Ginzberg, Stephen M. Richardson, Karoliina Pelttari, Girish Pattappa, Makarand V. Risbud, Ali Mobasheri
Publicado en: Nature Reviews Rheumatology, Edición 21, 2025, ISSN 1759-4790
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41584-025-01275-0

Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression

Autores: Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Publicado en: Theranostics, Edición 15, 2025, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/THNO.117788

Disruption of the microenvironmental ecosystem in subchondral bone marrow lesions: Roles in osteoarthritis pathophysiology, pain and progression

Autores: Ali Mobasheri, João Henriques, Jamie E. Collins
Publicado en: Osteoarthritis Imaging, Edición 6, 2026, ISSN 2772-6541
Editor: Elsevier BV
DOI: 10.1016/J.OSTIMA.2025.100374

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Autores: Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Publicado en: Connective Tissue Research, 2025, ISSN 0300-8207
Editor: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair

Autores: Marcus Mumme, Anke Wixmerten, Alan Ivkovic, Giuseppe M. Peretti, Tayfun Yilmaz, Stephan Reppenhagen, Oliver Pullig, Sylvie Miot, Kaywan Izadpanah, Marcel Jakob, Laura Mangiavini, Corrado Sosio, Filip Vuletić, Oliver Bieri, Stefano Biguzzi, Brigitta Gahl, Gyözö Lehoczky, Rudolf Vukojevic, Sebastian Häusner, Anna Gryadunova, Martin Haug, Andrea Barbero, Ivan Martin
Publicado en: Science Translational Medicine, Edición 17, 2025, ISSN 1946-6234
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADS0848

Rapidly progressive osteoarthritis (RPOA) in companion animals treated with bedinvetmab (Librela™): an expected pathophysiological phenomenon or a cause for concern?

Autores: Ali Mobasheri, Peter Hanson, Jonathan Larkin
Publicado en: Frontiers in Veterinary Science, Edición 12, 2025, ISSN 2297-1769
Editor: Frontiers Media SA
DOI: 10.3389/FVETS.2025.1640217

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Autores: Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Publicado en: Connective Tissue Research, Edición 66, 2026, ISSN 0300-8207
Editor: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Next-generation therapies for osteoarthritis: the evolving role of cell therapy products

Autores: Valtteri Peitso, Ron Ellis, Karman Ng, Simone Ponta, Rana Smaida, Nadia Benkirane-Jessel, Nancy P. Duarte-Delgado, Tobias Winkler, Goncalo Barreto, Jean-Yves Reginster, Ali Mobasheri
Publicado en: Experimental & Molecular Medicine, Edición 58, 2026, ISSN 2092-6413
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S12276-026-01726-Y

Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025

Autores: Patrik Kovács, Judit Vágó, Ali Mobasheri, Zsuzsa Jenei-Lanzl, Frank Zaucke, Henning Madry, László Csernoch, Zoltán Szekanecz, Zsuzsa Szondy, Árpád Szöőr, Istvan Szatmari, Tamás Oláh, Csaba Matta
Publicado en: Osteoarthritis and Cartilage Open, Edición 8, 2026, ISSN 2665-9131
Editor: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100728

Conference proceedings (2)

Nose to knee. State of Art in clinical application of GMP products of nasal chondrocytes

Autores: Marcus Mumme
Publicado en: TERMIS EU 2025 Freiburg
Editor: N/A

Early Osteoarthritic Lesions: A Therapeutic Dead-End or an Opportunity?

Autores: Marcus Mumme
Publicado en: Annual Congress Swiss Orthopaedics Zurich, 2025
Editor: N/A