ENgineered CArtilage from Nose for the Treatment of Osteoarthritis (ENCANTO)

Informazioni relative al progetto

ENCANTO

ID dell’accordo di sovvenzione: 101137315

DOI

10.3030/101137315

Data della firma CE 11 Dicembre 2023

Data di avvio 1 Gennaio 2024

Data di completamento 31 Dicembre 2029

Finanziato da

• Health

Costo totale

€ 8 363 555,00

Contributo UE

€ 8 363 555,00

Coordinato da

FONDAZIONE POLICLINICO UNIVERSITARIO CAMPUS BIO MEDICO
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Definition and implementation of digital rehabilitation program and monitoring

Defined rehabilitation program with corresponding videos and detailed instructions in all languages implemented in the online platform. Digital monitoring and data acquisitionimplemented in the rehabilitation protocol on four levels: 1) ability to perform a specific task within dailyprotocol, 2) VAS pain score on daily basis, 3) traffic light system and 4)Bassett patient self-report scales for elapsed rehabilitation week.

Dissemination and Communication Plan first version

Dissemination and Communication plan report

Websites, patent fillings, videos etc. (1)

Project Website

The public website of the project.

Pubblicazioni

Peer reviewed articles (14)

Looking Inwards: The Role of Self‐Care, Self‐Management and Self‐Healing in Musculoskeletal Pain

Autori: Joyce McSwan, Catherine E. Panwar, Ali Mobasheri
Pubblicato in: Musculoskeletal Care, Numero 23, 2025, ISSN 1478-2189
Editore: Wiley
DOI: 10.1002/MSC.70169

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Autori: Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Pubblicato in: Osteoarthritis and Cartilage Open, Numero 7, 2025, ISSN 2665-9131
Editore: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis

Autori: Paco Mattheus Jacobus Welsing, Said el Bouhaddani, Lin Zhu, Nienke C. Nijhof, Simon C. Mastbergen, Chunyi Wen, Jaume Bacardit, Cristina Ruiz-Romero, Francisco J. Blanco, Ali Mobasheri
Pubblicato in: Connective Tissue Research, Numero 66, 2026, ISSN 0300-8207
Editore: Informa UK Limited
DOI: 10.1080/03008207.2025.2541291

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Autori: Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Pubblicato in: Osteoarthritis and Cartilage Open, Numero 7, 2025, ISSN 2665-9131
Editore: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Bone health and pregnancy: Osteoporosis and beyond

Autori: Ali Mobasheri, Jean-Yves Reginster, Manju Chandran, Joyce McSwan
Pubblicato in: Case Reports in Women's Health, Numero 47, 2025, ISSN 2214-9112
Editore: Elsevier BV
DOI: 10.1016/J.CRWH.2025.E00725

Insights into chondrocyte populations in cartilaginous tissues at the single-cell level

Autori: Csaba Matta, Roland Takács, Mona Dvir-Ginzberg, Stephen M. Richardson, Karoliina Pelttari, Girish Pattappa, Makarand V. Risbud, Ali Mobasheri
Pubblicato in: Nature Reviews Rheumatology, Numero 21, 2025, ISSN 1759-4790
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41584-025-01275-0

Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression

Autori: Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Pubblicato in: Theranostics, Numero 15, 2025, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/THNO.117788

Disruption of the microenvironmental ecosystem in subchondral bone marrow lesions: Roles in osteoarthritis pathophysiology, pain and progression

Autori: Ali Mobasheri, João Henriques, Jamie E. Collins
Pubblicato in: Osteoarthritis Imaging, Numero 6, 2026, ISSN 2772-6541
Editore: Elsevier BV
DOI: 10.1016/J.OSTIMA.2025.100374

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Autori: Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Pubblicato in: Connective Tissue Research, 2025, ISSN 0300-8207
Editore: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair

Autori: Marcus Mumme, Anke Wixmerten, Alan Ivkovic, Giuseppe M. Peretti, Tayfun Yilmaz, Stephan Reppenhagen, Oliver Pullig, Sylvie Miot, Kaywan Izadpanah, Marcel Jakob, Laura Mangiavini, Corrado Sosio, Filip Vuletić, Oliver Bieri, Stefano Biguzzi, Brigitta Gahl, Gyözö Lehoczky, Rudolf Vukojevic, Sebastian Häusner, Anna Gryadunova, Martin Haug, Andrea Barbero, Ivan Martin
Pubblicato in: Science Translational Medicine, Numero 17, 2025, ISSN 1946-6234
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADS0848

Rapidly progressive osteoarthritis (RPOA) in companion animals treated with bedinvetmab (Librela™): an expected pathophysiological phenomenon or a cause for concern?

Autori: Ali Mobasheri, Peter Hanson, Jonathan Larkin
Pubblicato in: Frontiers in Veterinary Science, Numero 12, 2025, ISSN 2297-1769
Editore: Frontiers Media SA
DOI: 10.3389/FVETS.2025.1640217

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Autori: Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Pubblicato in: Connective Tissue Research, Numero 66, 2026, ISSN 0300-8207
Editore: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Next-generation therapies for osteoarthritis: the evolving role of cell therapy products

Autori: Valtteri Peitso, Ron Ellis, Karman Ng, Simone Ponta, Rana Smaida, Nadia Benkirane-Jessel, Nancy P. Duarte-Delgado, Tobias Winkler, Goncalo Barreto, Jean-Yves Reginster, Ali Mobasheri
Pubblicato in: Experimental & Molecular Medicine, Numero 58, 2026, ISSN 2092-6413
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S12276-026-01726-Y

Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025

Autori: Patrik Kovács, Judit Vágó, Ali Mobasheri, Zsuzsa Jenei-Lanzl, Frank Zaucke, Henning Madry, László Csernoch, Zoltán Szekanecz, Zsuzsa Szondy, Árpád Szöőr, Istvan Szatmari, Tamás Oláh, Csaba Matta
Pubblicato in: Osteoarthritis and Cartilage Open, Numero 8, 2026, ISSN 2665-9131
Editore: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100728

Conference proceedings (2)

Nose to knee. State of Art in clinical application of GMP products of nasal chondrocytes

Autori: Marcus Mumme
Pubblicato in: TERMIS EU 2025 Freiburg
Editore: N/A

Early Osteoarthritic Lesions: A Therapeutic Dead-End or an Opportunity?

Autori: Marcus Mumme
Pubblicato in: Annual Congress Swiss Orthopaedics Zurich, 2025
Editore: N/A