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CORDIS - EU research results
CORDIS

Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to answer science and policy needS

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Map of available methodologies for RA of EDCs (opens in new window)

Report summarizing available methodologies in different RA frameworks for EDCs

Cluster policy strategy_1 (opens in new window)

Cluster policy strategy

A map of EDC mixture effects on liver toxicity (opens in new window)

Report on combinatorial effects of EDCs in human liver toxicity

Common cluster activities (opens in new window)

Common cluster activities, including a common dissemination and communication strategy for the cluster

Cluster scientific strategy (opens in new window)

Includes thematic workshops/trainings on issues of common interests. Planned workshops M24, M36, M48, M54

NEMESIS D&C plan (opens in new window)

Detailed project dissemination and communication plan (living document)

FAIR research data management plan (RDMP)_2 (opens in new window)

Procedures for collecting, organizing, storing, and sharing research data - full version

Cluster data management plan (opens in new window)

Common data management plans

FAIR research data management plan (RDMP)_1 (opens in new window)

Procedures for collecting, organizing, storing, and sharing research data - initial version

Publications

Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Nodes (opens in new window)

Author(s): Haralampos Tzoupis, Michail Papadourakis, Konstantinos D. Papavasileiou, Oliver Burk, Volker M. Lauschke, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis
Published in: Journal of Chemical Information and Modeling, Issue 65, 2025, ISSN 1549-9596
Publisher: American Chemical Society (ACS)
DOI: 10.5281/ZENODO.17698827

Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells (opens in new window)

Author(s): Maria Lytrivi, Yue Tong, Enrico Virgilio, Xiaoyan Yi, Miriam Cnop
Published in: Nature Reviews Endocrinology, 2025, ISSN 1759-5029
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41574-025-01129-5

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays (opens in new window)

Author(s): Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke
Published in: Advanced Biology, Issue 9, 2026, ISSN 2701-0198
Publisher: Wiley
DOI: 10.1002/ADBI.202500337

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression (opens in new window)

Author(s): Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen
Published in: Basic & Clinical Pharmacology & Toxicology, Issue 138, 2026, ISSN 1742-7835
Publisher: Wiley
DOI: 10.1111/BCPT.70218

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS (opens in new window)

Author(s): Bustamante, Carolina M.; Bravo, Natalia; Ruiz, Paula; Grimalt, Joan O.; Garí, Mercè
Published in: Journal of Chromatography A, 2024, ISSN 1873-3778
Publisher: Elsevier
DOI: 10.1016/J.CHROMA.2024.465054

The Evolving Landscape of Pharmacogenomics: Current Achievements and Future Directions (opens in new window)

Author(s): Volker M. Lauschke; Magnus Ingelman-Sundberg
Published in: Pharmacological Reviews, 2026, ISSN 1521-0081
Publisher: ASPET
DOI: 10.1016/J.PHARMR.2026.100122

Microbiota modulates compound-specific toxicity of environmental chemicals: A multi-omics analysis in zebrafish embryos (opens in new window)

Author(s): Lydia Gugescu, Ying Yang, Judy Fabienne Kool, Nanna Fyhrquist, Emma Wincent, Harri Alenius
Published in: Environment International, Issue 204, 2025, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109828

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro (opens in new window)

Author(s): Tia Heikkinen, Jenni Küblbeck, Jaana Rysä
Published in: Archives of Toxicology, 2025, ISSN 0340-5761
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-03957-W

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review (opens in new window)

Author(s): Tomasz Gogola, Sini Pitkänen, Marjo Huovinen, Heikki Laitinen, Jenni Küblbeck
Published in: Environmental Research, Issue 273, 2025, ISSN 0013-9351
Publisher: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121186

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies (opens in new window)

Author(s): Henriikka Hakomäki; Sini Pitkänen; Anna-Liisa Levonen; Paavo Honkakoski; Dario Greco; Laura Aliisa Saarimäki; Susana Viegas; Cristina Godinho; Nanna Fyhrquist; Emma Wincent; Volker M Lauschke; Janne Hukkanen; Jukka Hakkola; Ludovic Vallier; Vittorio Fortino; Antreas Afantitis; Toshiaki Sawatani; Tereso J Guzman; Miriam Cnop; Tim Nawrot; Sophia Harlid; Marie-Therese Vinnars; Adonina Tardon; Joan O Grimalt; Jenni Küblbeck; Jaana Rysä
Published in: Open Research Europe, 2024, ISSN 2732-5121
Publisher: European Commission
DOI: 10.12688/OPENRESEUROPE.18439.1

Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects (opens in new window)

Author(s): Julia Swan, D. Zhurenko, K. M. Huttunen, J. Rysä
Published in: Archives of Toxicology, 2025, ISSN 0340-5761
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04203-Z

Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening (opens in new window)

Author(s): Rohollah Nasiri, Masoud Madadelahi, Mohammad Reza Nikmaneshi, Begum Gokce, Mohamad Ali Bijarchi, Shilp Shah, Zuzana Tirpáková, Dirkje Van Gastel, Nayere Taebnia, Natan Roberto de Barros, Yangzhi Zhu, Zehra Gul Morcimen, Baris Gulicli, Rouhollah Habibey, Aylin Sendemir, Saumey Jain, Alessandro Enrico, Volker M. Lauschke, Mehmet Remzi Dokmeci, Guillem Pratx, Ali Khademhosseini, Anna Herland
Published in: Biomaterials, Issue 327, 2025, ISSN 0142-9612
Publisher: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123739

Methodological approach for a simultaneous determination of persistent and non-persistent organic pollutants in human blood (serum/plasma) using gas chromatography and mass spectrometry techniques (opens in new window)

Author(s): Carolina M. Bustamante; Paula Ruiz; Atiya B. Rifat; Natalia Bravo; Joan O. Grimalt; Mercè Garí
Published in: Journal of Chromatography A, 2025, ISSN 1873-3778
Publisher: Elsevier
DOI: 10.1016/J.CHROMA.2025.466235

A Systematic Literature Review of Reproductive Toxicological Studies on Phthalates (opens in new window)

Author(s): Muhammad Moghazy, Marianthi Papathanasiou, Haralampos Tzoupis, Konstantinos D. Papavasileiou, Chen Xing, Volker M. Lauschke, Antreas Afantitis, Georgia Melagraki
Published in: International Journal of Molecular Sciences, Issue 26, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS26188761

Nuclear receptors CAR and PXR as cardiometabolic regulators (opens in new window)

Author(s): Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä
Published in: Pharmacological Research, Issue 219, 2025, ISSN 1043-6618
Publisher: Elsevier BV
DOI: 10.1016/J.PHRS.2025.107892

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