Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to answer science and policy needS

Deliverables

Map of available methodologies for RA of EDCs

Report summarizing available methodologies in different RA frameworks for EDCs

Cluster policy strategy_1

Cluster policy strategy

A map of EDC mixture effects on liver toxicity

Report on combinatorial effects of EDCs in human liver toxicity

Common cluster activities

Common cluster activities, including a common dissemination and communication strategy for the cluster

Cluster scientific strategy

Includes thematic workshops/trainings on issues of common interests. Planned workshops M24, M36, M48, M54

NEMESIS D&C plan

Detailed project dissemination and communication plan (living document)

NEMESIS Initial press release

Initial press release describing the overall goals and ambition

Cluster newsletter_1

1st Cluster newsletter

Cluster brochure
NEMESIS Brochure

Leaflet on information for dissemination (events)

NEMESIS website

A project dedicated public website (continuously updated)

Cluster web portal and visual identity

FAIR research data management plan (RDMP)_2

Procedures for collecting, organizing, storing, and sharing research data - full version

Cluster data management plan

Common data management plans

FAIR research data management plan (RDMP)_1

Procedures for collecting, organizing, storing, and sharing research data - initial version

Publications

Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Nodes

Author(s): Haralampos Tzoupis, Michail Papadourakis, Konstantinos D. Papavasileiou, Oliver Burk, Volker M. Lauschke, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis
Published in: Journal of Chemical Information and Modeling, Issue 65, 2025, ISSN 1549-9596
Publisher: American Chemical Society (ACS)
DOI: 10.5281/ZENODO.17698827

Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells

Author(s): Maria Lytrivi, Yue Tong, Enrico Virgilio, Xiaoyan Yi, Miriam Cnop
Published in: Nature Reviews Endocrinology, 2025, ISSN 1759-5029
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41574-025-01129-5

Real-world performance of an AI system for diabetic retinopathy screening

Author(s): Lina Berrada, Laurent Crenier, Maria Lytrivi, Agnes Burniat, Elie Motulsky, Miriam Cnop
Published in: Scientific Reports, Issue 16, 2026, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-37292-6

Facilitated DNA damage repair as an emerging therapeutic strategy for inflammatory and fibrotic diseases

Author(s): Maurice Michel; Nayere Taebnia; Volker M. Lauschke
Published in: RSC Chemical Biology, 2026, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/D5CB00327J

From pancreas and islet resources to diabetes insights

Author(s): Sing-Young Chen, Christiana Lekka, Jonas Lemvig, Xiaoyan Yi, Miriam Cnop, Piero Marchetti, Lorella Marselli, Jianguo Xia, Jesper G. S. Madsen, Teresa Rodriguez-Calvo, Sarah J. Richardson, James D. Johnson, Patrick E. MacDonald
Published in: Diabetologia, Issue 69, 2026, ISSN 0012-186X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00125-026-06731-4

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Author(s): Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke
Published in: Advanced Biology, Issue 9, 2026, ISSN 2701-0198
Publisher: Wiley
DOI: 10.1002/ADBI.202500337

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Author(s): Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen
Published in: Basic & Clinical Pharmacology & Toxicology, Issue 138, 2026, ISSN 1742-7835
Publisher: Wiley
DOI: 10.1111/BCPT.70218

Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in mice

Author(s): Chenyang Fu, Tingting Li, Yiming Hao, Yiting Lin, Yixuan Qiu, Yangyang Jia, Jie Yang, Bei Liu, Duanyi Hua, Chengyang Wang, Tao Chen, Anthony Piron, Miriam Cnop, Qicheng Ni, Jie Zheng, Guang Ning, Yanyun Gu
Published in: Diabetologia, Issue 69, 2026, ISSN 0012-186X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00125-025-06618-W

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

Author(s): Bustamante, Carolina M.; Bravo, Natalia; Ruiz, Paula; Grimalt, Joan O.; Garí, Mercè
Published in: Journal of Chromatography A, 2024, ISSN 1873-3778
Publisher: Elsevier
DOI: 10.1016/J.CHROMA.2024.465054

Per- and Polyfluoroalkyl Substances in Urine Samples from Eight-Year-Old Children Living in Northwest Spain

Author(s): Arianna Bautista, Guillermo Fernandez-Tardon, Marta M. Rodríguez-Suárez, Adonina Tardon, Natalia Bravo, Mercè Garí, Joan O. Grimalt, Marta Llorca, Marinella Farré
Published in: Molecules, Issue 31, 2026, ISSN 1420-3049
Publisher: MDPI AG
DOI: 10.3390/MOLECULES31050900

The Evolving Landscape of Pharmacogenomics: Current Achievements and Future Directions

Author(s): Volker M. Lauschke; Magnus Ingelman-Sundberg
Published in: Pharmacological Reviews, 2026, ISSN 1521-0081
Publisher: ASPET
DOI: 10.1016/J.PHARMR.2026.100122

Microbiota modulates compound-specific toxicity of environmental chemicals: A multi-omics analysis in zebrafish embryos

Author(s): Lydia Gugescu, Ying Yang, Judy Fabienne Kool, Nanna Fyhrquist, Emma Wincent, Harri Alenius
Published in: Environment International, Issue 204, 2025, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109828

Recessive TMEM167A variants cause neonatal diabetes, microcephaly, and epilepsy syndrome

Author(s): Enrico Virgilio, Sylvia Tielens, Georgia Bonfield, Fang-Shin Nian, Toshiaki Sawatani, Chiara Vinci, Molly Govier, Hossam Montaser, Romane Lartigue, Anoop Arunagiri, Alexandrine Liboz, Flavia Natividade Da Silva, Maria Lytrivi, Theodora Papadopoulou, Matthew N. Wakeling, James Russ-Silsby, Pamela Bowman, Matthew B. Johnson, Thomas W. Laver, Anthony Piron, Xiaoyan Yi, Federica Fantuzzi, Sirine Hendrickx, Mariana Igoillo-Esteve, Bruno J. Santacreu, Jananie Suntharesan, Radha Ghildiyal, Darshan Hegde, Nikhil Shah, Sezer Acar, Beyhan Özkaya Dönmez, Behzat Özkan, Fauzia Mohsin, Iman M. Talaat, Mohamed Tarek Abbas, Omar Tarek Abbas, Hamed Ali Alghamdi, Nurgun Kandemir, Sarah E. Flanagan, Raphael Scharfmann, Peter Arvan, Matthieu Raoux, Laurent Nguyen, Andrew T. Hattersley, Miriam Cnop, Elisa De Franco
Published in: Journal of Clinical Investigation, Issue 135, 2026, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI195756

Iron deficiency induces maturation-dependent loss of pancreatic β-cells

Author(s): Annelore Van Mulders, Lien Willems, Sophie Coenen, Stephanie Bourgeois, Xiaoyan Yi, Yue Tong, Gunter Leuckx, Yves Heremans, Julie Pierreux, Laure Degroote, Toshiaki Sawatani, Chiara Vinci, Gamze Ates, Ann Massie, Françoise Carlotti, Eelco de Koning, Thomas Mandrup-Poulsen, Clara Zelinsky, Steven Goderis, Bart Ghesquière, Raphael Scharfmann, Miriam Cnop, Nico De Leu, Willem Staels
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-69574-Y

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Author(s): Tia Heikkinen, Jenni Küblbeck, Jaana Rysä
Published in: Archives of Toxicology, 2025, ISSN 0340-5761
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-03957-W

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review

Author(s): Tomasz Gogola, Sini Pitkänen, Marjo Huovinen, Heikki Laitinen, Jenni Küblbeck
Published in: Environmental Research, Issue 273, 2025, ISSN 0013-9351
Publisher: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121186

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Author(s): Henriikka Hakomäki; Sini Pitkänen; Anna-Liisa Levonen; Paavo Honkakoski; Dario Greco; Laura Aliisa Saarimäki; Susana Viegas; Cristina Godinho; Nanna Fyhrquist; Emma Wincent; Volker M Lauschke; Janne Hukkanen; Jukka Hakkola; Ludovic Vallier; Vittorio Fortino; Antreas Afantitis; Toshiaki Sawatani; Tereso J Guzman; Miriam Cnop; Tim Nawrot; Sophia Harlid; Marie-Therese Vinnars; Adonina Tardon; Joan O Grimalt; Jenni Küblbeck; Jaana Rysä
Published in: Open Research Europe, 2024, ISSN 2732-5121
Publisher: European Commission
DOI: 10.12688/OPENRESEUROPE.18439.1

Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches

Author(s): Mara Suleiman, Toshiaki Sawatani, Marta Tesi, Xiaoyan Yi, Theodora Papadopoulou, Chantal Rufer, Maria Lytrivi, Emanuele Bosi, Frederic Burdet, Federica Fantuzzi, Carmela De Luca, Guido Sebastiani, Chiara Saponaro, Licia Anna Pugliese, Silvia Del Guerra, Alessandro Pocai, Paolo De Simone, Davide Ghinolfi, Ugo Boggi, Camille Kessler, Giuseppina Emanuela Grieco, Daniela Fignani, Julie Kerr-Conte, François Pattou, Montserrat Nacher, Eduard Montanya, Nizar Mourad, Antoine Buemi, Valentina Citi, Alma Martelli, Giada Benedetti, Vincenzo Calderone, Leonardo Rossi, Aldo Paolicchi, Francesco Cardarelli, Francesco Dotta, Decio L. Eizirik, Mark Ibberson, Piero Marchetti, Miriam Cnop, Lorella Marselli
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADS2905

Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects

Author(s): Julia Swan, D. Zhurenko, K. M. Huttunen, J. Rysä
Published in: Archives of Toxicology, 2025, ISSN 0340-5761
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04203-Z

Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening

Author(s): Rohollah Nasiri, Masoud Madadelahi, Mohammad Reza Nikmaneshi, Begum Gokce, Mohamad Ali Bijarchi, Shilp Shah, Zuzana Tirpáková, Dirkje Van Gastel, Nayere Taebnia, Natan Roberto de Barros, Yangzhi Zhu, Zehra Gul Morcimen, Baris Gulicli, Rouhollah Habibey, Aylin Sendemir, Saumey Jain, Alessandro Enrico, Volker M. Lauschke, Mehmet Remzi Dokmeci, Guillem Pratx, Ali Khademhosseini, Anna Herland
Published in: Biomaterials, Issue 327, 2025, ISSN 0142-9612
Publisher: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123739

A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data

Author(s): Yue Tong, Marianne Becker, Ulrike Schierloh, Flávia Natividade da Silva, Leena Haataja, Ying Cai, Kashyap A Patel, Farah Kobaisi, Uyenlinh L Mirshahi, Kevin Colclough, Muhammad Shabab Javed, Matthew N Wakeling, Federica Fantuzzi, Maria Lytrivi, Toshiaki Sawatani, Maria Nicol Arroyo, Xiaoyan Yi, Chiara Vinci, Hossam Montaser, Nathalie Pachera, Timo Otonkoski, Mariana Igoillo-Esteve, Raphaël Scharfmann, Andrew T Hattersley, Peter Arvan, Carine De Beaufort, Miriam Cnop
Published in: EMBO Molecular Medicine, Issue 18, 2026, ISSN 1757-4684
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44321-025-00362-9

Methodological approach for a simultaneous determination of persistent and non-persistent organic pollutants in human blood (serum/plasma) using gas chromatography and mass spectrometry techniques

Author(s): Carolina M. Bustamante; Paula Ruiz; Atiya B. Rifat; Natalia Bravo; Joan O. Grimalt; Mercè Garí
Published in: Journal of Chromatography A, 2025, ISSN 1873-3778
Publisher: Elsevier
DOI: 10.1016/J.CHROMA.2025.466235

A Systematic Literature Review of Reproductive Toxicological Studies on Phthalates

Author(s): Muhammad Moghazy, Marianthi Papathanasiou, Haralampos Tzoupis, Konstantinos D. Papavasileiou, Chen Xing, Volker M. Lauschke, Antreas Afantitis, Georgia Melagraki
Published in: International Journal of Molecular Sciences, Issue 26, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS26188761

Nuclear receptors CAR and PXR as cardiometabolic regulators

Author(s): Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä
Published in: Pharmacological Research, Issue 219, 2025, ISSN 1043-6618
Publisher: Elsevier BV
DOI: 10.1016/J.PHRS.2025.107892

Deliverables

Publications

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