Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to answer science and policy needS

Informazioni relative al progetto

NEMESIS

ID dell’accordo di sovvenzione: 101137405

DOI

10.3030/101137405

Data della firma CE 8 Dicembre 2023

Data di avvio 1 Gennaio 2024

Data di completamento 31 Dicembre 2028

Finanziato da

• Health

Costo totale

€ 7 965 638,75

Contributo UE

€ 7 881 685,25

Coordinato da

ITA-SUOMEN YLIOPISTO
Finland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

NEMESIS D&C plan

Detailed project dissemination and communication plan (living document)

A map of EDC mixture effects on liver toxicity

Report on combinatorial effects of EDCs in human liver toxicity

Cluster policy strategy_1

Cluster policy strategy

Common cluster activities

Common cluster activities, including a common dissemination and communication strategy for the cluster

Cluster scientific strategy

Includes thematic workshops/trainings on issues of common interests. Planned workshops M24, M36, M48, M54

Map of available methodologies for RA of EDCs

Report summarizing available methodologies in different RA frameworks for EDCs

Websites, patent fillings, videos etc. (6)

Cluster newsletter_1

1st Cluster newsletter

NEMESIS Brochure

Leaflet on information for dissemination (events)

NEMESIS website

A project dedicated public website (continuously updated)

Cluster brochure
NEMESIS Initial press release

Initial press release describing the overall goals and ambition

Cluster web portal and visual identity

Data Management Plan (3)

FAIR research data management plan (RDMP)_1

Procedures for collecting, organizing, storing, and sharing research data - initial version

Cluster data management plan

Common data management plans

FAIR research data management plan (RDMP)_2

Procedures for collecting, organizing, storing, and sharing research data - full version

Pubblicazioni

Peer reviewed articles (10)

Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells

Autori: Maria Lytrivi, Yue Tong, Enrico Virgilio, Xiaoyan Yi, Miriam Cnop
Pubblicato in: Nature Reviews Endocrinology, 2025, ISSN 1759-5029
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41574-025-01129-5

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

Autori: Carolina M. Bustamante, Natalia Bravo, Paula Ruiz, Joan O. Grimalt, Mercè Garí
Pubblicato in: Journal of Chromatography A, Numero 1730, 2024, ISSN 0021-9673
Editore: Elsevier BV
DOI: 10.1016/j.chroma.2024.465054

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

Autori: Bustamante, Carolina M.; Bravo, Natalia; Ruiz, Paula; Grimalt, Joan O.; Garí, Mercè
Pubblicato in: Journal of Chromatography A, 2024, ISSN 1873-3778
Editore: Elsevier
DOI: 10.1016/J.CHROMA.2024.465054

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Autori: Tia Heikkinen, Jenni Küblbeck, Jaana Rysä
Pubblicato in: Archives of Toxicology, 2025, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-03957-W

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review

Autori: Tomasz Gogola, Sini Pitkänen, Marjo Huovinen, Heikki Laitinen, Jenni Küblbeck
Pubblicato in: Environmental Research, Numero 273, 2025, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121186

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Autori: Henriikka Hakomäki; Sini Pitkänen; Anna-Liisa Levonen; Paavo Honkakoski; Dario Greco; Laura Aliisa Saarimäki; Susana Viegas; Cristina Godinho; Nanna Fyhrquist; Emma Wincent; Volker M Lauschke; Janne Hukkanen; Jukka Hakkola; Ludovic Vallier; Vittorio Fortino; Antreas Afantitis; Toshiaki Sawatani; Tereso J Guzman; Miriam Cnop; Tim Nawrot; Sophia Harlid; Marie-Therese Vinnars; Adonina Tardon; Joan O Grimalt; Jenni Küblbeck; Jaana Rysä
Pubblicato in: Open Research Europe, 2024, ISSN 2732-5121
Editore: European Commission
DOI: 10.12688/OPENRESEUROPE.18439.1

Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects

Autori: Julia Swan, D. Zhurenko, K. M. Huttunen, J. Rysä
Pubblicato in: Archives of Toxicology, 2025, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04203-Z

Methodological approach for a simultaneous determination of persistent and non-persistent organic pollutants in human blood (serum/plasma) using gas chromatography and mass spectrometry techniques

Autori: Carolina M. Bustamante; Paula Ruiz; Atiya B. Rifat; Natalia Bravo; Joan O. Grimalt; Mercè Garí
Pubblicato in: Journal of Chromatography A, 2025, ISSN 1873-3778
Editore: Elsevier
DOI: 10.1016/J.CHROMA.2025.466235

A Systematic Literature Review of Reproductive Toxicological Studies on Phthalates

Autori: Muhammad Moghazy, Marianthi Papathanasiou, Haralampos Tzoupis, Konstantinos D. Papavasileiou, Chen Xing, Volker M. Lauschke, Antreas Afantitis, Georgia Melagraki
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS26188761

Nuclear receptors CAR and PXR as cardiometabolic regulators

Autori: Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä
Pubblicato in: Pharmacological Research, Numero 219, 2025, ISSN 1043-6618
Editore: Elsevier BV
DOI: 10.1016/J.PHRS.2025.107892