Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to answer science and policy needS

Informations projet

NEMESIS

N° de convention de subvention: 101137405

DOI

10.3030/101137405

Date de signature de la CE 8 Decembre 2023

Date de début 1 Janvier 2024

Date de fin 31 Decembre 2028

Financé au titre de

• Health

Coût total

€ 7 965 638,75

Contribution de l’UE

€ 7 881 685,25

Coordonné par

ITA-SUOMEN YLIOPISTO
Finland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Map of available methodologies for RA of EDCs

Report summarizing available methodologies in different RA frameworks for EDCs

Cluster policy strategy_1

Cluster policy strategy

A map of EDC mixture effects on liver toxicity

Report on combinatorial effects of EDCs in human liver toxicity

Common cluster activities

Common cluster activities, including a common dissemination and communication strategy for the cluster

Cluster scientific strategy

Includes thematic workshops/trainings on issues of common interests. Planned workshops M24, M36, M48, M54

NEMESIS D&C plan

Detailed project dissemination and communication plan (living document)

Websites, patent fillings, videos etc. (6)

NEMESIS Initial press release

Initial press release describing the overall goals and ambition

Cluster newsletter_1

1st Cluster newsletter

Cluster brochure
NEMESIS Brochure

Leaflet on information for dissemination (events)

NEMESIS website

A project dedicated public website (continuously updated)

Cluster web portal and visual identity

Data Management Plan (3)

FAIR research data management plan (RDMP)_2

Procedures for collecting, organizing, storing, and sharing research data - full version

Cluster data management plan

Common data management plans

FAIR research data management plan (RDMP)_1

Procedures for collecting, organizing, storing, and sharing research data - initial version

Publications

Peer reviewed articles (24)

Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Nodes

Auteurs: Haralampos Tzoupis, Michail Papadourakis, Konstantinos D. Papavasileiou, Oliver Burk, Volker M. Lauschke, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis
Publié dans: Journal of Chemical Information and Modeling, Numéro 65, 2025, ISSN 1549-9596
Éditeur: American Chemical Society (ACS)
DOI: 10.5281/ZENODO.17698827

Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells

Auteurs: Maria Lytrivi, Yue Tong, Enrico Virgilio, Xiaoyan Yi, Miriam Cnop
Publié dans: Nature Reviews Endocrinology, 2025, ISSN 1759-5029
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41574-025-01129-5

Real-world performance of an AI system for diabetic retinopathy screening

Auteurs: Lina Berrada, Laurent Crenier, Maria Lytrivi, Agnes Burniat, Elie Motulsky, Miriam Cnop
Publié dans: Scientific Reports, Numéro 16, 2026, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-37292-6

Facilitated DNA damage repair as an emerging therapeutic strategy for inflammatory and fibrotic diseases

Auteurs: Maurice Michel; Nayere Taebnia; Volker M. Lauschke
Publié dans: RSC Chemical Biology, 2026, ISSN 2633-0679
Éditeur: Royal Society of Chemistry
DOI: 10.1039/D5CB00327J

From pancreas and islet resources to diabetes insights

Auteurs: Sing-Young Chen, Christiana Lekka, Jonas Lemvig, Xiaoyan Yi, Miriam Cnop, Piero Marchetti, Lorella Marselli, Jianguo Xia, Jesper G. S. Madsen, Teresa Rodriguez-Calvo, Sarah J. Richardson, James D. Johnson, Patrick E. MacDonald
Publié dans: Diabetologia, Numéro 69, 2026, ISSN 0012-186X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00125-026-06731-4

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Auteurs: Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke
Publié dans: Advanced Biology, Numéro 9, 2026, ISSN 2701-0198
Éditeur: Wiley
DOI: 10.1002/ADBI.202500337

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Auteurs: Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 138, 2026, ISSN 1742-7835
Éditeur: Wiley
DOI: 10.1111/BCPT.70218

Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in mice

Auteurs: Chenyang Fu, Tingting Li, Yiming Hao, Yiting Lin, Yixuan Qiu, Yangyang Jia, Jie Yang, Bei Liu, Duanyi Hua, Chengyang Wang, Tao Chen, Anthony Piron, Miriam Cnop, Qicheng Ni, Jie Zheng, Guang Ning, Yanyun Gu
Publié dans: Diabetologia, Numéro 69, 2026, ISSN 0012-186X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00125-025-06618-W

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

Auteurs: Bustamante, Carolina M.; Bravo, Natalia; Ruiz, Paula; Grimalt, Joan O.; Garí, Mercè
Publié dans: Journal of Chromatography A, 2024, ISSN 1873-3778
Éditeur: Elsevier
DOI: 10.1016/J.CHROMA.2024.465054

Per- and Polyfluoroalkyl Substances in Urine Samples from Eight-Year-Old Children Living in Northwest Spain

Auteurs: Arianna Bautista, Guillermo Fernandez-Tardon, Marta M. Rodríguez-Suárez, Adonina Tardon, Natalia Bravo, Mercè Garí, Joan O. Grimalt, Marta Llorca, Marinella Farré
Publié dans: Molecules, Numéro 31, 2026, ISSN 1420-3049
Éditeur: MDPI AG
DOI: 10.3390/MOLECULES31050900

The Evolving Landscape of Pharmacogenomics: Current Achievements and Future Directions

Auteurs: Volker M. Lauschke; Magnus Ingelman-Sundberg
Publié dans: Pharmacological Reviews, 2026, ISSN 1521-0081
Éditeur: ASPET
DOI: 10.1016/J.PHARMR.2026.100122

Microbiota modulates compound-specific toxicity of environmental chemicals: A multi-omics analysis in zebrafish embryos

Auteurs: Lydia Gugescu, Ying Yang, Judy Fabienne Kool, Nanna Fyhrquist, Emma Wincent, Harri Alenius
Publié dans: Environment International, Numéro 204, 2025, ISSN 0160-4120
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109828

Recessive TMEM167A variants cause neonatal diabetes, microcephaly, and epilepsy syndrome

Auteurs: Enrico Virgilio, Sylvia Tielens, Georgia Bonfield, Fang-Shin Nian, Toshiaki Sawatani, Chiara Vinci, Molly Govier, Hossam Montaser, Romane Lartigue, Anoop Arunagiri, Alexandrine Liboz, Flavia Natividade Da Silva, Maria Lytrivi, Theodora Papadopoulou, Matthew N. Wakeling, James Russ-Silsby, Pamela Bowman, Matthew B. Johnson, Thomas W. Laver, Anthony Piron, Xiaoyan Yi, Federica Fantuzzi, Sirine Hendrickx, Mariana Igoillo-Esteve, Bruno J. Santacreu, Jananie Suntharesan, Radha Ghildiyal, Darshan Hegde, Nikhil Shah, Sezer Acar, Beyhan Özkaya Dönmez, Behzat Özkan, Fauzia Mohsin, Iman M. Talaat, Mohamed Tarek Abbas, Omar Tarek Abbas, Hamed Ali Alghamdi, Nurgun Kandemir, Sarah E. Flanagan, Raphael Scharfmann, Peter Arvan, Matthieu Raoux, Laurent Nguyen, Andrew T. Hattersley, Miriam Cnop, Elisa De Franco
Publié dans: Journal of Clinical Investigation, Numéro 135, 2026, ISSN 1558-8238
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI195756

Iron deficiency induces maturation-dependent loss of pancreatic β-cells

Auteurs: Annelore Van Mulders, Lien Willems, Sophie Coenen, Stephanie Bourgeois, Xiaoyan Yi, Yue Tong, Gunter Leuckx, Yves Heremans, Julie Pierreux, Laure Degroote, Toshiaki Sawatani, Chiara Vinci, Gamze Ates, Ann Massie, Françoise Carlotti, Eelco de Koning, Thomas Mandrup-Poulsen, Clara Zelinsky, Steven Goderis, Bart Ghesquière, Raphael Scharfmann, Miriam Cnop, Nico De Leu, Willem Staels
Publié dans: Nature Communications, Numéro 17, 2026, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-69574-Y

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Auteurs: Tia Heikkinen, Jenni Küblbeck, Jaana Rysä
Publié dans: Archives of Toxicology, 2025, ISSN 0340-5761
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-03957-W

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review

Auteurs: Tomasz Gogola, Sini Pitkänen, Marjo Huovinen, Heikki Laitinen, Jenni Küblbeck
Publié dans: Environmental Research, Numéro 273, 2025, ISSN 0013-9351
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121186

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Auteurs: Henriikka Hakomäki; Sini Pitkänen; Anna-Liisa Levonen; Paavo Honkakoski; Dario Greco; Laura Aliisa Saarimäki; Susana Viegas; Cristina Godinho; Nanna Fyhrquist; Emma Wincent; Volker M Lauschke; Janne Hukkanen; Jukka Hakkola; Ludovic Vallier; Vittorio Fortino; Antreas Afantitis; Toshiaki Sawatani; Tereso J Guzman; Miriam Cnop; Tim Nawrot; Sophia Harlid; Marie-Therese Vinnars; Adonina Tardon; Joan O Grimalt; Jenni Küblbeck; Jaana Rysä
Publié dans: Open Research Europe, 2024, ISSN 2732-5121
Éditeur: European Commission
DOI: 10.12688/OPENRESEUROPE.18439.1

Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches

Auteurs: Mara Suleiman, Toshiaki Sawatani, Marta Tesi, Xiaoyan Yi, Theodora Papadopoulou, Chantal Rufer, Maria Lytrivi, Emanuele Bosi, Frederic Burdet, Federica Fantuzzi, Carmela De Luca, Guido Sebastiani, Chiara Saponaro, Licia Anna Pugliese, Silvia Del Guerra, Alessandro Pocai, Paolo De Simone, Davide Ghinolfi, Ugo Boggi, Camille Kessler, Giuseppina Emanuela Grieco, Daniela Fignani, Julie Kerr-Conte, François Pattou, Montserrat Nacher, Eduard Montanya, Nizar Mourad, Antoine Buemi, Valentina Citi, Alma Martelli, Giada Benedetti, Vincenzo Calderone, Leonardo Rossi, Aldo Paolicchi, Francesco Cardarelli, Francesco Dotta, Decio L. Eizirik, Mark Ibberson, Piero Marchetti, Miriam Cnop, Lorella Marselli
Publié dans: Science Advances, Numéro 11, 2025, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADS2905

Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects

Auteurs: Julia Swan, D. Zhurenko, K. M. Huttunen, J. Rysä
Publié dans: Archives of Toxicology, 2025, ISSN 0340-5761
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04203-Z

Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening

Auteurs: Rohollah Nasiri, Masoud Madadelahi, Mohammad Reza Nikmaneshi, Begum Gokce, Mohamad Ali Bijarchi, Shilp Shah, Zuzana Tirpáková, Dirkje Van Gastel, Nayere Taebnia, Natan Roberto de Barros, Yangzhi Zhu, Zehra Gul Morcimen, Baris Gulicli, Rouhollah Habibey, Aylin Sendemir, Saumey Jain, Alessandro Enrico, Volker M. Lauschke, Mehmet Remzi Dokmeci, Guillem Pratx, Ali Khademhosseini, Anna Herland
Publié dans: Biomaterials, Numéro 327, 2025, ISSN 0142-9612
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123739

A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data

Auteurs: Yue Tong, Marianne Becker, Ulrike Schierloh, Flávia Natividade da Silva, Leena Haataja, Ying Cai, Kashyap A Patel, Farah Kobaisi, Uyenlinh L Mirshahi, Kevin Colclough, Muhammad Shabab Javed, Matthew N Wakeling, Federica Fantuzzi, Maria Lytrivi, Toshiaki Sawatani, Maria Nicol Arroyo, Xiaoyan Yi, Chiara Vinci, Hossam Montaser, Nathalie Pachera, Timo Otonkoski, Mariana Igoillo-Esteve, Raphaël Scharfmann, Andrew T Hattersley, Peter Arvan, Carine De Beaufort, Miriam Cnop
Publié dans: EMBO Molecular Medicine, Numéro 18, 2026, ISSN 1757-4684
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S44321-025-00362-9

Methodological approach for a simultaneous determination of persistent and non-persistent organic pollutants in human blood (serum/plasma) using gas chromatography and mass spectrometry techniques

Auteurs: Carolina M. Bustamante; Paula Ruiz; Atiya B. Rifat; Natalia Bravo; Joan O. Grimalt; Mercè Garí
Publié dans: Journal of Chromatography A, 2025, ISSN 1873-3778
Éditeur: Elsevier
DOI: 10.1016/J.CHROMA.2025.466235

A Systematic Literature Review of Reproductive Toxicological Studies on Phthalates

Auteurs: Muhammad Moghazy, Marianthi Papathanasiou, Haralampos Tzoupis, Konstantinos D. Papavasileiou, Chen Xing, Volker M. Lauschke, Antreas Afantitis, Georgia Melagraki
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/IJMS26188761

Nuclear receptors CAR and PXR as cardiometabolic regulators

Auteurs: Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä
Publié dans: Pharmacological Research, Numéro 219, 2025, ISSN 1043-6618
Éditeur: Elsevier BV
DOI: 10.1016/J.PHRS.2025.107892