Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to answer science and policy needS

Informations projet

NEMESIS

N° de convention de subvention: 101137405

DOI

10.3030/101137405

Date de signature de la CE 8 Decembre 2023

Date de début 1 Janvier 2024

Date de fin 31 Decembre 2028

Financé au titre de

• Health

Coût total

€ 7 965 638,75

Contribution de l’UE

€ 7 881 685,25

Coordonné par

ITA-SUOMEN YLIOPISTO
Finland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Map of available methodologies for RA of EDCs

Report summarizing available methodologies in different RA frameworks for EDCs

Cluster policy strategy_1

Cluster policy strategy

A map of EDC mixture effects on liver toxicity

Report on combinatorial effects of EDCs in human liver toxicity

Common cluster activities

Common cluster activities, including a common dissemination and communication strategy for the cluster

Cluster scientific strategy

Includes thematic workshops/trainings on issues of common interests. Planned workshops M24, M36, M48, M54

NEMESIS D&C plan

Detailed project dissemination and communication plan (living document)

Websites, patent fillings, videos etc. (6)

NEMESIS Initial press release

Initial press release describing the overall goals and ambition

Cluster newsletter_1

1st Cluster newsletter

Cluster brochure
NEMESIS Brochure

Leaflet on information for dissemination (events)

NEMESIS website

A project dedicated public website (continuously updated)

Cluster web portal and visual identity

Data Management Plan (3)

FAIR research data management plan (RDMP)_2

Procedures for collecting, organizing, storing, and sharing research data - full version

Cluster data management plan

Common data management plans

FAIR research data management plan (RDMP)_1

Procedures for collecting, organizing, storing, and sharing research data - initial version

Publications

Peer reviewed articles (15)

Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Nodes

Auteurs: Haralampos Tzoupis, Michail Papadourakis, Konstantinos D. Papavasileiou, Oliver Burk, Volker M. Lauschke, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis
Publié dans: Journal of Chemical Information and Modeling, Numéro 65, 2025, ISSN 1549-9596
Éditeur: American Chemical Society (ACS)
DOI: 10.5281/ZENODO.17698827

Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells

Auteurs: Maria Lytrivi, Yue Tong, Enrico Virgilio, Xiaoyan Yi, Miriam Cnop
Publié dans: Nature Reviews Endocrinology, 2025, ISSN 1759-5029
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41574-025-01129-5

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Auteurs: Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke
Publié dans: Advanced Biology, Numéro 9, 2026, ISSN 2701-0198
Éditeur: Wiley
DOI: 10.1002/ADBI.202500337

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Auteurs: Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen
Publié dans: Basic & Clinical Pharmacology & Toxicology, Numéro 138, 2026, ISSN 1742-7835
Éditeur: Wiley
DOI: 10.1111/BCPT.70218

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

Auteurs: Bustamante, Carolina M.; Bravo, Natalia; Ruiz, Paula; Grimalt, Joan O.; Garí, Mercè
Publié dans: Journal of Chromatography A, 2024, ISSN 1873-3778
Éditeur: Elsevier
DOI: 10.1016/J.CHROMA.2024.465054

The Evolving Landscape of Pharmacogenomics: Current Achievements and Future Directions

Auteurs: Volker M. Lauschke; Magnus Ingelman-Sundberg
Publié dans: Pharmacological Reviews, 2026, ISSN 1521-0081
Éditeur: ASPET
DOI: 10.1016/J.PHARMR.2026.100122

Microbiota modulates compound-specific toxicity of environmental chemicals: A multi-omics analysis in zebrafish embryos

Auteurs: Lydia Gugescu, Ying Yang, Judy Fabienne Kool, Nanna Fyhrquist, Emma Wincent, Harri Alenius
Publié dans: Environment International, Numéro 204, 2025, ISSN 0160-4120
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109828

Metabolic disruption by mycotoxins: focus on metabolic endpoints steatosis, adipogenesis and glucose metabolism in vivo and in vitro

Auteurs: Tia Heikkinen, Jenni Küblbeck, Jaana Rysä
Publié dans: Archives of Toxicology, 2025, ISSN 0340-5761
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-03957-W

Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review

Auteurs: Tomasz Gogola, Sini Pitkänen, Marjo Huovinen, Heikki Laitinen, Jenni Küblbeck
Publié dans: Environmental Research, Numéro 273, 2025, ISSN 0013-9351
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121186

Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies

Auteurs: Henriikka Hakomäki; Sini Pitkänen; Anna-Liisa Levonen; Paavo Honkakoski; Dario Greco; Laura Aliisa Saarimäki; Susana Viegas; Cristina Godinho; Nanna Fyhrquist; Emma Wincent; Volker M Lauschke; Janne Hukkanen; Jukka Hakkola; Ludovic Vallier; Vittorio Fortino; Antreas Afantitis; Toshiaki Sawatani; Tereso J Guzman; Miriam Cnop; Tim Nawrot; Sophia Harlid; Marie-Therese Vinnars; Adonina Tardon; Joan O Grimalt; Jenni Küblbeck; Jaana Rysä
Publié dans: Open Research Europe, 2024, ISSN 2732-5121
Éditeur: European Commission
DOI: 10.12688/OPENRESEUROPE.18439.1

Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects

Auteurs: Julia Swan, D. Zhurenko, K. M. Huttunen, J. Rysä
Publié dans: Archives of Toxicology, 2025, ISSN 0340-5761
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04203-Z

Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening

Auteurs: Rohollah Nasiri, Masoud Madadelahi, Mohammad Reza Nikmaneshi, Begum Gokce, Mohamad Ali Bijarchi, Shilp Shah, Zuzana Tirpáková, Dirkje Van Gastel, Nayere Taebnia, Natan Roberto de Barros, Yangzhi Zhu, Zehra Gul Morcimen, Baris Gulicli, Rouhollah Habibey, Aylin Sendemir, Saumey Jain, Alessandro Enrico, Volker M. Lauschke, Mehmet Remzi Dokmeci, Guillem Pratx, Ali Khademhosseini, Anna Herland
Publié dans: Biomaterials, Numéro 327, 2025, ISSN 0142-9612
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123739

Methodological approach for a simultaneous determination of persistent and non-persistent organic pollutants in human blood (serum/plasma) using gas chromatography and mass spectrometry techniques

Auteurs: Carolina M. Bustamante; Paula Ruiz; Atiya B. Rifat; Natalia Bravo; Joan O. Grimalt; Mercè Garí
Publié dans: Journal of Chromatography A, 2025, ISSN 1873-3778
Éditeur: Elsevier
DOI: 10.1016/J.CHROMA.2025.466235

A Systematic Literature Review of Reproductive Toxicological Studies on Phthalates

Auteurs: Muhammad Moghazy, Marianthi Papathanasiou, Haralampos Tzoupis, Konstantinos D. Papavasileiou, Chen Xing, Volker M. Lauschke, Antreas Afantitis, Georgia Melagraki
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/IJMS26188761

Nuclear receptors CAR and PXR as cardiometabolic regulators

Auteurs: Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä
Publié dans: Pharmacological Research, Numéro 219, 2025, ISSN 1043-6618
Éditeur: Elsevier BV
DOI: 10.1016/J.PHRS.2025.107892