VAScularised Tumour Organoids on a chip with human placenta vessels as a preclinical model for anticancer therapies.

Informazioni relative al progetto

VASTO

ID dell’accordo di sovvenzione: 101138214

DOI

10.3030/101138214

Progetto chiuso

Data della firma CE 21 Agosto 2023

Data di avvio 1 Novembre 2023

Data di completamento 30 Aprile 2025

Finanziato da

• European Research Council (ERC)

Costo totale

Nessun dato

Contributo UE

€ 150 000,00

Coordinato da

UNIVERSIDAD DE ZARAGOZA
Spain

Periodic Reporting for period 1 - VASTO (VAScularised Tumour Organoids on a chip with human placenta vessels as a preclinical model for anticancer therapies.)

Periodo di rendicontazione: 2023-11-01 al 2025-04-30

Sintesi del contesto e degli obiettivi generali del progetto

The VASTO project has successfully integrated diverse scientific disciplines and methodologies into a single platform, presenting both scientific and technical challenges. The goal was to develop an improved in vitro model for cancer research and a testing platform for novel immunotherapies. Within this framework, we designed and developed different approaches, ranging from simpler to more complex systems. The first simpler microfluidic system involves a microfluidic chip, a hydrogel matrix and tumour spheroids This system allows to monitor the dynamics of tumour spheroid response. . The final system, on the other hand, constitutes the technological basis for filling an international patent, which is being applied now. For this reason, dissemination of the project has been reduced. Additionally, we have evaluated the possibility of establishing a biomedical start-up company as one the industrial partner for commercialize the developed system.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

In the VASTO project, we developed different approaches to testing immunotherapies against cancer. In all cases, we obtained relevant results and achieved significant progress. It is noted that in the most complex microfluidic system, we obtained several significant findings that are pending to be protected by a patent.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

The technique and methods describing different aspects of the complex platform developed are being finalized and prepared for a patent application in a joint effort of Instituto de Investigación Sanitaria de Aragon (IIS-Aragon), ARAID and University of Zaragoza (UNIZAR).