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Bioactive polyphenolic compounds from brown macroalgae: A mechanistic study on pig gut health promoting effects (BioAlgae)

Descrizione del progetto

Composti bioattivi delle macroalghe brune per migliorare la salute intestinale dei suini

La moderna produzione suina fa largo uso di antibiotici nell’alimentazione, vietati in Europa, per controllare la diarrea post-svezzamento (PWD) e migliorare la salute intestinale durante lo svezzamento. I ricercatori stanno studiando i composti bioattivi ricavati dalle macroalghe brune, tra cui il florotannino (Pt), come potenziale alternativa. Lo svezzamento influisce sulla salute dell’intestino, sullo stato energetico, sul microbiota intestinale (GM) e sull’integrità della mucosa dei suini. Sostenuto dal programma di azioni Marie Skłodowska-Curie, il progetto BioAlgae esaminerà l’impatto del Pt su patogeni enterici come l’E. coli, il GM, l’immunità mucosale e la funzione della barriera intestinale. Il progetto si propone di stabilire come tali effetti possano contribuire alla gestione della PWD nei suini giovani. I risultati dovrebbero incrementare la produttività dei suini svezzati.

Obiettivo

Modern pig production hugely depends on in-feed antibiotics to control postweaning diarrhea (PWD) and improve pig gut health during weaning. However, the use of in-feed antibiotics and zinc oxide (ZnO) has already been banned in Europe prompting an urgent need for alternative solutions. Currently, there is emerging interest in various bioactive compounds from brown macroalgae such as the polyphenolic compound phlorotannin (Pt) as a potential alternative due to their diverse biological activities. Weaning in pig compromises not only short-term gut health or reduces energy status, or alters gut microbiota (GM), but also disrupts mucosal integrity increasing susceptibility to infection and negatively influencing long-term health. Therefore, it can be hypothesized that improving immune status, enhancing intestinal barrier functions, and inhibiting specific harmful microbes using Pt can lead to both short-term favorable GM profile and long-term beneficial impacts on immunity and resistance against infection. Therefore, the objectives of this study are to investigate the effects of Pt on the enteric pathogen such as E. coli, GM, mucosal immunity and intestinal barrier function, and how these effects can be utilized to mitigate PWD in weaned pigs. Given my background and my supervisors’ track record in the gut health as well as the use of macroalgae in livestock as alternative to antibiotics, I have firm conviction in the successful achievement of the objectives of this project. The effects of Pt are expected to be reflected in improved pig gut health, reduced mortality and enhanced productivity in weaned pigs. This has huge implications in Europe to fill the vacuum created by the banning of in-feed antibiotics and ZnO. Moreover, this research project can complement the skills gained from my PhD project by filling some of the skill gaps which are important to develop my envisioned career by strengthening my hands-on lab and overall research skills in pig gut health.

Campo scientifico (EuroSciVoc)

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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(si apre in una nuova finestra) HORIZON-MSCA-2023-PF-01

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Coordinatore

NORD UNIVERSITET
Contributo netto dell'UE
€ 226 751,04
Indirizzo
UNIVERSITETSALLEEN 11
8026 BODO
Norvegia
Regione
Norge Oslo og Viken Oslo
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Partner (1)