Descrizione del progetto
Trattamento della psoriasi assistito da micro-aghi
La psoriasi è una malattia infiammatoria cronica della pelle caratterizzata da un rapido accumulo di cellule cutanee, che porta alla formazione di chiazze rosse e pruriginose sulla pelle. Di solito si applica una terapia topica, ma la sua efficacia è limitata a causa della bassa permeabilità cutanea. Finanziato dal programma di azioni Marie Skłodowska-Curie, il progetto MAPiT propone di sfruttare i cerotti ad array di micro-aghi (MAP) per migliorare la permeabilità cutanea ed evitare i rischi associati ai farmaci sistemici per la psoriasi. I ricercatori caricheranno i MAP con nanoparticelle contenenti inibitori del fattore di necrosi tumorale (TNF), noti per il loro potere antinfiammatorio. L’approccio MAPiT dovrebbe portare a concentrazioni più elevate del trattamento anti-psoriasi nella pelle, migliorando i risultati terapeutici.
Obiettivo
Psoriasis, an autoimmune disorder characterized by keratinocyte hyperproliferation, predominantly manifests as plaque-type psoriasis, with a majority of cases being mild to moderate. Current treatment approaches, such as topical therapy, often fall short due to limited skin permeability. Systemic drugs and biologics, while effective, pose risks associated with high doses. Addressing mild psoriasis presents the challenge of overcoming limited skin permeability and minimizing systemic drug toxicity. Microneedle Array patches (MAPs) offer a promising alternative. They breach the stratum corneum, facilitating intradermal drug delivery, resulting in higher localized drug concentrations compared to systemic or topical administration. Given the pivotal role of TNF-α in psoriasis, I bring expertise in various MAP fabrication techniques, nanomaterials for drug and mRNA delivery, and their applications. By collaborating with the host, we aim to develop an innovative nanomedicine-based strategy. This approach involves encapsulating TNF-α inhibitors in calcium phosphate nanoparticles using flame spray pyrolysis and loading them into MAPs. The research will encompass various parameters, including size, encapsulation efficiency, release kinetics, mechanical strength, morphology, safety, and in vitro efficacy assessment. Beyond the research project, I will engage in personal development courses, gain exposure to state-of-the-art laboratory facilities, and participate in conferences. Additionally, I will mentor Master's and Ph.D. students, honing my project management skills, and collaborate with industry experts and clinicians to explore the formulation's potential.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Meccanismo di finanziamento
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinatore
17177 Stockholm
Svezia