Project description
Exploring Nature's Microbial Arsenal to Tackle Antibiotic Resistance
Antibiotic resistance and the scarcity of new drug discoveries pose a threat to global health, as microbial pathogens evolve more rapidly than treatments can be developed. Addressing this urgent need requires the search for novel bioactive compounds. Traditional methods often neglect potential sources of new drugs, particularly within lesser-known microbial genera. This oversight necessitates innovative approaches to uncover hidden pharmacological treasures. The PhyloDRS project, supported by the Marie Skłodowska-Curie Actions programme, leverages 2D and 3D cell cultures to investigate the genomic landscape of underexplored actinobacterial genera. Utilising state-of-the-art sequencing and cultivation techniques, the project aims to stimulate the production of cryptic metabolites. Through advanced analytical chemistry, new bioactive compounds will be identified and tested, enhancing the discovery of valuable pharmaceuticals.
Objective
The project titled, 'Phylogenomic-driven Drug Discovery from Rhodococcus and Saccharomonospora using 2D and 3D Cell Cultures' aims to explore the microbial diversity and genomic landscape of two important, yet somewhat neglected, natural product producing actinobacterial genera, Rhodococcus and Saccharomonospora. Symbiotic systems and unique habitats will serve as isolation sources of novel species, and I will employ state-of-the-art sequencing techniques to perform a comprehensive in depth phylogenomic analysis to fully depict their biocatalytic repertoire and by doing so, unravel their unique natural product potential. I will spearhead the establishment of novel 2D and 3D cultivation techniques with ecomimetic properties to mimic natural scenarios and thereby trigger the production of cryptic metabolites. I will employ sophisticated dereplication and chemical analytical strategies to characterize and structurally elucidate novel chemical entities with drug-like scaffolds. Based on these results, I will be able to test all of the identified natural products for their pharmacological properties within the framework of the Helmholtz drug discovery pipeline and collaboration partners. My targeted and interdisciplinary research approach will allow me to gain valuable genomic and evolutionary insights and streamline the discovery of pharmaceutically valuable natural product scaffolds.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
38124 Braunschweig
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.