Boosting Sustainable Innovation in Developing New Antibiotic Adjuvants to Control Biofilm Resistance

Información del proyecto

InnovAntiBiofilm

Identificador del acuerdo de subvención: 101157363

DOI

10.3030/101157363

Fecha de la firma de la CE 10 Mayo 2024

Fecha de inicio 1 Octubre 2024

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

Sin datos

Aportación de la UE

€ 1 483 246,42

Coordinado por

UNIVERSIDADE DO PORTO
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Communication, Dissemination and Exploitation Plan

A detailed Communication, Dissemination and Exploitation Plan (CDEP) will be produced. The CDEP will outline the audiences, key messages and communication channels for dissemination. The CDEP will provide an integrated, inclusive, accurate and efficient communication, dissemination and exploitation strategy to fully promote the benefits of InnovAntiBiofilm and it will include a calendar of events (both internal and external) and a (first) list of stakeholders and end-users with a view to engage the most relevant actors.

Methods for Shikimic Acid Isolation and Purification

The isolation and purification of shikimic acid will include fermentation liquid pre-treatment. Shikimic acid will be purified by preparative HPLC/MS.

Catalogue of Industrial Stakeholders

UPORTO, CEA and Fraunhofer IME will contribute with their contacts and networks for an industrial stakeholder list that will be produced by KPMG.

Data Management Plan (1)

Data Management Plan

A Data Management Plan will be developed and periodically updated during the lifetime of the project (living document), tackling issues related to data privacy, security, visibility of internal business, trust, regulatory frameworks, use of personal data, business sensitive data, and data protection standards as established by the EU General Data Protection Regulation rules.

Publicaciones

Peer reviewed articles (20)

Science of the Total Environment

Autores: Afonso, Ana C.; Botting, Jack; Gomes, Inês B.; Saavedra, Maria J.; Simões, Lúcia Chaves; Liu, Jun; Simões, Manuel
Publicado en: Science of The Total Environment, 2024, ISSN 0048-9697
Editor: Elsevier
DOI: 10.1016/J.SCITOTENV.2024.174872

Protocol for in silico characterization of natural-based molecules as quorum-sensing inhibitors

Autores: Susana Fernandes; Mariana Sousa; Fábio G. Martins; Manuel Simões; Sérgio F. Sousa
Publicado en: STAR Protocols, Edición 5, 2024, ISSN 2666-1667
Editor: Cell Press
DOI: 10.1016/J.XPRO.2024.103367

Two cinnamic acid derivatives as inhibitors of Pseudomonas aeruginosa las and pqs quorum-sensing systems: Impact on biofilm formation and virulence factors

Autores: Miguel M. Leitão, Ariana S.C. Gonçalves, Sérgio F. Sousa, Fernanda Borges, Manuel Simões, Anabela Borges
Publicado en: Biomedicine & Pharmacotherapy, Edición 187, 2025, ISSN 0753-3322
Editor: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.118090

Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms

Autores: Miguel M. Leitão, Ariana S.C. Gonçalves, Joana Moreira, Carlos Fernandes, Fernanda Borges, Manuel Simões, Anabela Borges
Publicado en: European Journal of Medicinal Chemistry, Edición 283, 2025, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/J.EJMECH.2024.117163

The action of selected monoterpenes as biofilm control agents and antibiotic resistance modifiers

Autores: Francisca Massano, Ana C. Afonso, Mariana Sousa, Lília S. Teixeira, Anabela Borges, Manuel Simões
Publicado en: Biofouling, 2026, ISSN 0892-7014
Editor: Taylor & Francis
DOI: 10.1080/08927014.2026.2615081

The role of the proteosurfaceome and exoproteome in bacterial coaggregation

Autores: Ana C. Afonso, Maria J. Saavedra, Manuel Simões, Lúcia C. Simões
Publicado en: Biotechnology Advances, Edición 79, 2025, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/J.BIOTECHADV.2024.108505

Elucidating bacterial coaggregation through a physicochemical and imaging surface characterization

Autores: Ana C. Afonso, Jack Botting, Inês B. Gomes, Maria J. Saavedra, Lúcia C. Simões, Jun Liu, Manuel Simões
Publicado en: Science of The Total Environment, Edición 948, 2025, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.174872

New insights on antibacterial mode of action of blue-light photoactivated berberine and curcumin-antibiotic combinations against Staphylococcus aureus

Autores: Ariana S.C. Gonçalves, José R. Fernandes, Maria José Saavedra, Nuno M. Guimarães, Cristiana Pereira, Manuel Simões, Anabela Borges
Publicado en: Photodiagnosis and Photodynamic Therapy, Edición 52, 2025, ISSN 1572-1000
Editor: Elsevier BV
DOI: 10.1016/J.PDPDT.2025.104514

Antimicrobial cyclodextrin-assisted electrospun fibers loaded with carvacrol, citronellol and cinnamic acid for wound healing

Autores: Iago Gonzalez-Prada, Anabela Borges, Beatriz Santos-Torres, Beatriz Magariños, Manuel Simões, Angel Concheiro, Carmen Alvarez-Lorenzo
Publicado en: International Journal of Biological Macromolecules, Edición 277, 2024, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/J.IJBIOMAC.2024.134154

Coaggregation dynamics in drinking water biofilms and implications for chlorine disinfection

Autores: Ana C. Afonso, Inês B. Gomes, Francisca Massano, Maria J. Saavedra, Manuel Simões, Lúcia C. Simões
Publicado en: Journal of Hazardous Materials, Edición 480, 2025, ISSN 0304-3894
Editor: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2024.135948

Photodynamic activation of phytochemical-antibiotic combinations for combatting Staphylococcus aureus from acute wound infections

Autores: Ariana S.C. Gonçalves, Miguel M. Leitão, José R. Fernandes, Maria José Saavedra, Cristiana Pereira, Manuel Simões, Anabela Borges
Publicado en: Journal of Photochemistry and Photobiology B: Biology, Edición 258, 2024, ISSN 1011-1344
Editor: Elsevier BV
DOI: 10.1016/J.JPHOTOBIOL.2024.112978

Polypharmacological strategies for infectious bacteria

Autores: Miguel M. Leitão, Ariana S.C. Gonçalves, Fernanda Borges, Manuel Simões, Anabela Borges
Publicado en: Pharmacological Reviews, Edición 77, 2025, ISSN 0031-6997
Editor: Elsevier BV
DOI: 10.1016/J.PHARMR.2025.100038

Biocides as drivers of antibiotic resistance: A critical review of environmental implications and public health risks

Autores: Mariana Sousa, Idalina Machado, Lúcia C. Simões, Manuel Simões
Publicado en: Environmental Science and Ecotechnology, Edición 25, 2025, ISSN 2666-4984
Editor: Elsevier BV
DOI: 10.1016/J.ESE.2025.100557

Current microbiological challenges in drinking water

Autores: Ana C. Afonso, Maria J. Saavedra, Inês B. Gomes, Manuel Simões, Lúcia C. Simões
Publicado en: Journal of Water Process Engineering, Edición 72, 2025, ISSN 2214-7144
Editor: Elsevier BV
DOI: 10.1016/J.JWPE.2025.107614

The ability of Salmonella enterica subsp. enterica strains to form biofilms on abiotic surfaces and their susceptibility to selected essential oil components

Autores: Pérez-Lavalle, Liliana; Borges, Anabela; Gomes, Inês; Carrasco, Elena; Valero, Antonio; Simões, Manuel
Publicado en: Letters Applied Microbiology, Edición 78, ISSN 1472-765X
Editor: Oxford Academi
DOI: 10.1093/LAMBIO/OVAF032

AHL-based QS signalling promotes uropathogenic Escherichia coli settlement through the de-repression of biofilm formation by SdiA

Autores: Celia Mayer, Fadi Soukarieh, Manuel Simões, Saskia-Camille Flament-Simon, Miguel Cámara, Manuel Romero
Publicado en: PLOS One, Edición 20, 2025, ISSN 1932-6203
Editor: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0328837

The impact of methylparaben and chlorine on the architecture of Stenotrophomonas maltophilia biofilms

Autores: Ana Rita Pereira, Liam M. Rooney, Inês B. Gomes, Manuel Simões, Gail McConnell
Publicado en: Science of The Total Environment, Edición 951, 2024, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.175646

Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibiotic efficacy for controlling Pseudomonas aeruginosa biofilms

Autores: Miguel M. Leitão, Tatiana F. Vieira, Sérgio F. Sousa, Fernanda Borges, Manuel Simões, Anabela Borges
Publicado en: Microbial Pathogenesis, Edición 191, 2024, ISSN 0882-4010
Editor: Elsevier BV
DOI: 10.1016/J.MICPATH.2024.106663

Antibacterial Effects of Novel Quaternary Ammonium and Phosphonium Salts against Staphylococcus aureus

Autores: Nunes, Bárbara; Cagide, Feranando; Borges, Anabela; Borges, Fernanda; Simões, Manuel
Publicado en: Journal of Applied Microbiology, ISSN 1365-2672
Editor: Oxford Academcic
DOI: 10.1093/JAMBIO/LXAF122

Exploring grape pomace extracts for the formulation of new bioactive multifunctional chitosan/alginate-based hydrogels for wound healing applications

Autores: Lília S. Teixeira, Mariana Sousa, Francisca Massano, Anabela Borges
Publicado en: Food Bioscience, Edición 62, 2025, ISSN 2212-4292
Editor: Elsevier BV
DOI: 10.1016/J.FBIO.2024.105073

Other (3)

COMMUNICATION, DISSEMINATION AND EXPLOITATION PLAN FOR THE INNOVANTIBIOFILM PROJECT

Autores: Simões, Manuel; Borges, Anabela; Gomes, Inês
Publicado en: ZENODO, 2024
DOI: 10.5281/ZENODO.14753656

GUIDELINES FOR STAFF EXCHANGE OF THE INNOVANTIBIOFILM PROJECT

Autores: Simões, Manuel; Oliveira Afonso, Ana Cristina; Gomes, Inês; Borges, Anabela
Publicado en: ZENODO, 2025
DOI: 10.5281/ZENODO.15280872

DATA MANAGEMENT PLAN FOR THE INNOVANTIBIOFILM PROJECT

Autores: Simões, Manuel; Oliveira Afonso, Ana Cristina; Gomes, Inês; Borges, Anabela
Publicado en: ZENODO, 2025
DOI: 10.5281/ZENODO.15280816