Boosting Sustainable Innovation in Developing New Antibiotic Adjuvants to Control Biofilm Resistance

Informazioni relative al progetto

InnovAntiBiofilm

ID dell’accordo di sovvenzione: 101157363

DOI

10.3030/101157363

Data della firma CE 10 Maggio 2024

Data di avvio 1 Ottobre 2024

Data di completamento 30 Settembre 2027

Finanziato da

• Widening participation and spreading excellence

Costo totale

Nessun dato

Contributo UE

€ 1 483 246,42

Coordinato da

UNIVERSIDADE DO PORTO
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Communication, Dissemination and Exploitation Plan

A detailed Communication, Dissemination and Exploitation Plan (CDEP) will be produced. The CDEP will outline the audiences, key messages and communication channels for dissemination. The CDEP will provide an integrated, inclusive, accurate and efficient communication, dissemination and exploitation strategy to fully promote the benefits of InnovAntiBiofilm and it will include a calendar of events (both internal and external) and a (first) list of stakeholders and end-users with a view to engage the most relevant actors.

Methods for Shikimic Acid Isolation and Purification

The isolation and purification of shikimic acid will include fermentation liquid pre-treatment. Shikimic acid will be purified by preparative HPLC/MS.

Catalogue of Industrial Stakeholders

UPORTO, CEA and Fraunhofer IME will contribute with their contacts and networks for an industrial stakeholder list that will be produced by KPMG.

Data Management Plan (1)

Data Management Plan

A Data Management Plan will be developed and periodically updated during the lifetime of the project (living document), tackling issues related to data privacy, security, visibility of internal business, trust, regulatory frameworks, use of personal data, business sensitive data, and data protection standards as established by the EU General Data Protection Regulation rules.

Pubblicazioni

Peer reviewed articles (20)

Science of the Total Environment

Autori: Afonso, Ana C.; Botting, Jack; Gomes, Inês B.; Saavedra, Maria J.; Simões, Lúcia Chaves; Liu, Jun; Simões, Manuel
Pubblicato in: Science of The Total Environment, 2024, ISSN 0048-9697
Editore: Elsevier
DOI: 10.1016/J.SCITOTENV.2024.174872

Protocol for in silico characterization of natural-based molecules as quorum-sensing inhibitors

Autori: Susana Fernandes; Mariana Sousa; Fábio G. Martins; Manuel Simões; Sérgio F. Sousa
Pubblicato in: STAR Protocols, Numero 5, 2024, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/J.XPRO.2024.103367

Two cinnamic acid derivatives as inhibitors of Pseudomonas aeruginosa las and pqs quorum-sensing systems: Impact on biofilm formation and virulence factors

Autori: Miguel M. Leitão, Ariana S.C. Gonçalves, Sérgio F. Sousa, Fernanda Borges, Manuel Simões, Anabela Borges
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 187, 2025, ISSN 0753-3322
Editore: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.118090

Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms

Autori: Miguel M. Leitão, Ariana S.C. Gonçalves, Joana Moreira, Carlos Fernandes, Fernanda Borges, Manuel Simões, Anabela Borges
Pubblicato in: European Journal of Medicinal Chemistry, Numero 283, 2025, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/J.EJMECH.2024.117163

The action of selected monoterpenes as biofilm control agents and antibiotic resistance modifiers

Autori: Francisca Massano, Ana C. Afonso, Mariana Sousa, Lília S. Teixeira, Anabela Borges, Manuel Simões
Pubblicato in: Biofouling, 2026, ISSN 0892-7014
Editore: Taylor & Francis
DOI: 10.1080/08927014.2026.2615081

The role of the proteosurfaceome and exoproteome in bacterial coaggregation

Autori: Ana C. Afonso, Maria J. Saavedra, Manuel Simões, Lúcia C. Simões
Pubblicato in: Biotechnology Advances, Numero 79, 2025, ISSN 0734-9750
Editore: Elsevier BV
DOI: 10.1016/J.BIOTECHADV.2024.108505

Elucidating bacterial coaggregation through a physicochemical and imaging surface characterization

Autori: Ana C. Afonso, Jack Botting, Inês B. Gomes, Maria J. Saavedra, Lúcia C. Simões, Jun Liu, Manuel Simões
Pubblicato in: Science of The Total Environment, Numero 948, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.174872

New insights on antibacterial mode of action of blue-light photoactivated berberine and curcumin-antibiotic combinations against Staphylococcus aureus

Autori: Ariana S.C. Gonçalves, José R. Fernandes, Maria José Saavedra, Nuno M. Guimarães, Cristiana Pereira, Manuel Simões, Anabela Borges
Pubblicato in: Photodiagnosis and Photodynamic Therapy, Numero 52, 2025, ISSN 1572-1000
Editore: Elsevier BV
DOI: 10.1016/J.PDPDT.2025.104514

Antimicrobial cyclodextrin-assisted electrospun fibers loaded with carvacrol, citronellol and cinnamic acid for wound healing

Autori: Iago Gonzalez-Prada, Anabela Borges, Beatriz Santos-Torres, Beatriz Magariños, Manuel Simões, Angel Concheiro, Carmen Alvarez-Lorenzo
Pubblicato in: International Journal of Biological Macromolecules, Numero 277, 2024, ISSN 0141-8130
Editore: Elsevier BV
DOI: 10.1016/J.IJBIOMAC.2024.134154

Coaggregation dynamics in drinking water biofilms and implications for chlorine disinfection

Autori: Ana C. Afonso, Inês B. Gomes, Francisca Massano, Maria J. Saavedra, Manuel Simões, Lúcia C. Simões
Pubblicato in: Journal of Hazardous Materials, Numero 480, 2025, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2024.135948

Photodynamic activation of phytochemical-antibiotic combinations for combatting Staphylococcus aureus from acute wound infections

Autori: Ariana S.C. Gonçalves, Miguel M. Leitão, José R. Fernandes, Maria José Saavedra, Cristiana Pereira, Manuel Simões, Anabela Borges
Pubblicato in: Journal of Photochemistry and Photobiology B: Biology, Numero 258, 2024, ISSN 1011-1344
Editore: Elsevier BV
DOI: 10.1016/J.JPHOTOBIOL.2024.112978

Polypharmacological strategies for infectious bacteria

Autori: Miguel M. Leitão, Ariana S.C. Gonçalves, Fernanda Borges, Manuel Simões, Anabela Borges
Pubblicato in: Pharmacological Reviews, Numero 77, 2025, ISSN 0031-6997
Editore: Elsevier BV
DOI: 10.1016/J.PHARMR.2025.100038

Biocides as drivers of antibiotic resistance: A critical review of environmental implications and public health risks

Autori: Mariana Sousa, Idalina Machado, Lúcia C. Simões, Manuel Simões
Pubblicato in: Environmental Science and Ecotechnology, Numero 25, 2025, ISSN 2666-4984
Editore: Elsevier BV
DOI: 10.1016/J.ESE.2025.100557

Current microbiological challenges in drinking water

Autori: Ana C. Afonso, Maria J. Saavedra, Inês B. Gomes, Manuel Simões, Lúcia C. Simões
Pubblicato in: Journal of Water Process Engineering, Numero 72, 2025, ISSN 2214-7144
Editore: Elsevier BV
DOI: 10.1016/J.JWPE.2025.107614

The ability of Salmonella enterica subsp. enterica strains to form biofilms on abiotic surfaces and their susceptibility to selected essential oil components

Autori: Pérez-Lavalle, Liliana; Borges, Anabela; Gomes, Inês; Carrasco, Elena; Valero, Antonio; Simões, Manuel
Pubblicato in: Letters Applied Microbiology, Numero 78, ISSN 1472-765X
Editore: Oxford Academi
DOI: 10.1093/LAMBIO/OVAF032

AHL-based QS signalling promotes uropathogenic Escherichia coli settlement through the de-repression of biofilm formation by SdiA

Autori: Celia Mayer, Fadi Soukarieh, Manuel Simões, Saskia-Camille Flament-Simon, Miguel Cámara, Manuel Romero
Pubblicato in: PLOS One, Numero 20, 2025, ISSN 1932-6203
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0328837

The impact of methylparaben and chlorine on the architecture of Stenotrophomonas maltophilia biofilms

Autori: Ana Rita Pereira, Liam M. Rooney, Inês B. Gomes, Manuel Simões, Gail McConnell
Pubblicato in: Science of The Total Environment, Numero 951, 2024, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.175646

Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibiotic efficacy for controlling Pseudomonas aeruginosa biofilms

Autori: Miguel M. Leitão, Tatiana F. Vieira, Sérgio F. Sousa, Fernanda Borges, Manuel Simões, Anabela Borges
Pubblicato in: Microbial Pathogenesis, Numero 191, 2024, ISSN 0882-4010
Editore: Elsevier BV
DOI: 10.1016/J.MICPATH.2024.106663

Antibacterial Effects of Novel Quaternary Ammonium and Phosphonium Salts against Staphylococcus aureus

Autori: Nunes, Bárbara; Cagide, Feranando; Borges, Anabela; Borges, Fernanda; Simões, Manuel
Pubblicato in: Journal of Applied Microbiology, ISSN 1365-2672
Editore: Oxford Academcic
DOI: 10.1093/JAMBIO/LXAF122

Exploring grape pomace extracts for the formulation of new bioactive multifunctional chitosan/alginate-based hydrogels for wound healing applications

Autori: Lília S. Teixeira, Mariana Sousa, Francisca Massano, Anabela Borges
Pubblicato in: Food Bioscience, Numero 62, 2025, ISSN 2212-4292
Editore: Elsevier BV
DOI: 10.1016/J.FBIO.2024.105073

Other (3)

COMMUNICATION, DISSEMINATION AND EXPLOITATION PLAN FOR THE INNOVANTIBIOFILM PROJECT

Autori: Simões, Manuel; Borges, Anabela; Gomes, Inês
Pubblicato in: ZENODO, 2024
DOI: 10.5281/ZENODO.14753656

GUIDELINES FOR STAFF EXCHANGE OF THE INNOVANTIBIOFILM PROJECT

Autori: Simões, Manuel; Oliveira Afonso, Ana Cristina; Gomes, Inês; Borges, Anabela
Pubblicato in: ZENODO, 2025
DOI: 10.5281/ZENODO.15280872

DATA MANAGEMENT PLAN FOR THE INNOVANTIBIOFILM PROJECT

Autori: Simões, Manuel; Oliveira Afonso, Ana Cristina; Gomes, Inês; Borges, Anabela
Pubblicato in: ZENODO, 2025
DOI: 10.5281/ZENODO.15280816