Project description
Type 2 diabetes prediction using epigenetic biomarkers
Type 2 Diabetes Mellitus (T2DM) is a prevalent disease with significant global impact. Prevailing predictive models are limited to pre-diabetic stages and hinder proactive intervention. Funded by the European Research Council, the PredRegNetworks project introduces a groundbreaking approach using novel epigenetic biomarkers. The idea is based on the role of enhancers and silencers in regulatory networks. By leveraging this knowledge, the proposed disease-prediction models are expected to achieve clinical-level accuracy even in non-diabetic individuals. These innovative models can identify at-risk individuals well before clinical symptoms manifest, offering a transformative opportunity for early intervention and preventive treatments. Validation of this approach could lead to the development of a pioneering clinical test for combatting T2D.
Objective
Type 2 Diabetes Mellitus (T2DM) is a heterogeneous disease, associated with mortality and severe morbidity, and affecting hundreds of millions of people around the globe. Despite some misconception accepted in the public, current models to predict the onset of T2DM have insufficient power, and are generally limited to individuals that already progressed into pre-diabetes states, at which the assignment of disease-preventing treatments is largely ineffective. Clinical-level prediction power (AUC>0.9) among non-diabetic individuals would enable effective pre-emptive strategies, but the way to produce such predictions remined unknown. Based on a new understanding of enhancer-silencer regulatory networks, I have developed a new class of supreme epigenetic biomarkers. Disease-prediction models that built on the basis of these novel understanding and biomarkers, significantly overpower the best currently-available prediction models. Importantly, these pioneering models can identify the people at risk well before the appearance of any clinical symptoms. Strong preliminary evidence signified the potential to develop the first clinical test to identify the risk to develop T2DM and associated diseases among non-pre-diabetic individuals at the required prediction power, and in time to deliver effective disease-preventing treatments. Validation of these results and demonstration of the effectiveness of the new clinical-level test will allows the directions of the effective (though expensive) preventing treatments to the people at risk, thus dramatically improve the way we are dealing with this harmful disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine endocrinology diabetes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
91904 JERUSALEM
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.