Project description
Increasing fibre intake with optimal metabolic output
Increasing dietary fibre intake is crucial for meeting guidelines and supporting the production of beneficial metabolites by gut microbiota, such as short-chain fatty acids (SCFAs). However, gut microbiota also produces gases, which can cause gastrointestinal symptoms in sensitive individuals. Gas formation varies between individuals and is influenced by factors such as gut pH and transit rate. The EIC-funded FIBRE-MATCH project aims to match dietary fibre types to gut microbiome subtypes to optimise metabolic output. This involves identifying major fibre-metabolising microbiome types in Europeans and developing fermented food prototypes to study whether microbiome-tailored foods can improve gastrointestinal symptoms. Additionally, the project will evaluate the impact of dietary fibre on non-communicable disease risk markers and analyse nutrition-microbiome interactions.
Objective
The consumption of dietary fibres (DF) should be increased to comply with the dietary guidelines and fuel various beneficial metabolites produced by the gut microbiota, such as short chain fatty acids (SCFA). Microbiota also produces gases that, in sensitive persons including irritable bowel syndrome patients (IBS), trigger disturbing and at worst disabling gastrointestinal (GI) symptoms, leading to the avoidance of fibre-rich foods. The gas formation patterns and amounts are highly individual and interrelated to GI parameters such as gut pH and transit rate.
FIBRE-MATCH develops and validates a concept to match DF types to gut microbiome subtypes for optimal metabolic output. The project identifies major DF-metabolising microbiome types prevalent in Europeans using existing metagenomic, dietary and GI symptom data, considering also endogenous glycans. Representative microbiomes and DF will be characterized in vitro to identify metabolic phenotypes. DF combinations yielding an optimal gas to SCFA ratio in vitro will be used to develop fermented food prototypes for proof-of-concept studies in healthy volunteers and IBS patients, to study whether consumption of the microbiome-tailored food improves GI symptoms and IBS markers compared to unmatched fibre, using breath monitoring, metagenome, metabolome and glycan analyses. Biosamples from the healthy subjects will be used to evaluate the effects of DF on risk markers of noncommunicable diseases using metabolomics approaches. A novel database of chemical composition of DF in high-fibre foods will be developed to enable analysis of nutrition-microbiome interactions at functional and molecular level.
FIBRE-MATCH fits to the Precision Nutrition Challenge portfolio as it develops fundamental knowledge, capabilities and resources that foster precision nutrition innovations related to individually-tailored microbiome-targeting foods, microbiome-based stratification, and ultimately decreasing the fibre gap.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences health sciences nutrition
- natural sciences biological sciences biochemistry biomolecules carbohydrates
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2023-PATHFINDERCHALLENGES-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00014 Helsinki
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.