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New chemical warheads for covalent drug discovery

Objective

Over the past two decades, the pharmaceutical industry has witnessed an exponential growth in approved covalent drugs. The majority of such drugs incorporate a chemical warhead, a mild electrophilic reactive functional group that forms covalent bonds in a reversible or irreversible manner with nucleophilic aminoacid residues. The aim of this proposal is to assess the viability of a new chemical warhead in the discovery of novel kinase inhibitors.

Keywords

Host institution

FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
Net EU contribution
€ 150 000,00
Address
AVENIDA PAISSOS CATALANS 16
43007 Tarragona
Spain

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Region
Este Cataluña Tarragona
Activity type
Research Organisations
Links
Total cost
No data

Beneficiaries (1)