Project description
Stereocontrol over non-classical carbocations for complex acyclic structures
Stereoselective synthesis is crucial in organic chemistry, allowing the precise formation of stereoisomers. Non-classical carbocations pose challenges due to their unpredictable reactivity, complicating stereocenter formation in acyclic molecules. The ERC-funded StereoCPC project aims to achieve stereocontrol over non-classical carbocations. It will first identify the necessary substitution patterns to generate these carbocations as single isomers. The focus will then shift to controlling their reactivity to form defined adjacent C-X and C-C bonds through molecular rearrangement. This approach will manage the unpredictability of non-classical carbocations and use their reactivities to create complex acyclic structures. Moreover, the project will develop new strategies for synthesising polysubstituted cyclobutanes and strained fused ring systems with bismetalated species, an achievement not yet accomplished.
Objective
Stereoselective synthesis is a central aspect of modern organic chemistry, enabling the precise formation of specific stereoisomers in complex molecular architectures. Key to this process are reactive intermediates such as carbenes, radicals, and carbocations. However, achieving complete stereocontrol over non-classical carbocations in the stereoselective synthesis of acyclic molecules remains a formidable challenge.
These fascinating carbocations, despite decades of research, exhibit unpredictable reactivity, making the controlled creation of stereocenters particularly difficult.
In this proposal, our primary goal is to achieve comprehensive stereocontrol over non-classical carbocations. We plan to accomplish this by first identifying the specific substitution pattern necessary to generate these carbocations as a single isomer. Then, we will focus on precisely controlling their reactivity to form stereodefined adjacent C–X and C–C bonds at distant positions from the initial carbocation, through molecular rearrangement. This approach not only aims to tame the unpredictable nature of non-classical carbocations but also to harness their reactivities to create highly complex and defined acyclic molecular structures. Additionally, we aim to pioneer new strategies for synthesizing polysubstituted cyclobutanes, and strained fused ring system utilizing bismetalated species, an accomplishment that has never been achieved, despite the growing use of these structures as potential bioisosteres.
These methods represent a significant advancement in the stereocontrolled synthesis of complex molecules, addressing longstanding challenges in regioselectivity, substitution patterns, and stereochemistry. By harnessing the unique reactivity of strained rings and non-classical carbocations, this research is set to unlock novel pathways to molecular architectures previously deemed unattainable, significantly enriching the synthetic toolbox of organic chemistry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-ADG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.