Objective
The lipopolysaccharide endotoxins (LPSs) are ubiquitous microbial cell surface glycolipids of Gram-negative bacteria and are key molecular actors in the interaction with eukaryotic hosts. Traditionally, studies have focused on the role of LPS as dangerous and potent molecules with the ability to boost innate immunity in eukaryotes and cause sepsis in humans and severe pathologies in plants. In recent years, however, it has become clear that LPS is not always working as a microbial weapon. Indeed, LPS also covers the surface of symbiotic and beneficial bacteria. However, a precise chemical and molecular information on this duality remains elusive. Two central questions remain unsolved with the required chemical precision: i) which are the key features of the molecular interactions between LPSs and the host receptors; ii) how the subsequent signalling pathways lead to either pathogenicity or symbiosis in mammals and in plants. Indeed, despite the harmful image of LPS, disentangling these features of LPS chemistry could inspire new avenues for the employment of LPS and LPS-like molecules as a novel generation of therapeutics in medicine and agriculture.
Thus, the key objective of LPS-CODE is to unravel the key features of the molecular interactions between LPS and the host receptors and decipher the subsequent signalling pathways in both animals and plants. This will be achieved by identifying the key microdomains within the LPS molecules that establish beneficial or detrimental interactions with the host, eventually driving elicitation or suppression of host innate immunity.
LPS-CODE is grounded on (bio)-organic chemistry and chemical biology, with strong emphasis on glycan chemistry and structural glycosciences to decode the microbial language and thus decipher the chemical epitopes common to either all “friendly” or pathogenic LPS in the interaction with both plants and animals. With this, we will finally be able to make the conceptual leap to conceive new molec
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- natural sciences biological sciences zoology mammalogy
- social sciences economics and business business and management employment
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2024-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80138 Napoli
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.