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Investigating DC migration with large, ingested cargos through confining environments

Project description

How Dendritic Cells migrate with large cargo

Dendritic cells (DCs) are immune sentinels, which ingest material and transport it to the draining lymph nodes to drive adaptive immunity. In environments containing mixed material, DCs need to migrate or move through a number of physical obstacles. Initial findings suggest that DCs deform or rotate very large particles and, at times, exhibit nuclear deformation or some form of migratory limitation, resembling observations made in vivo. The DCsConCargo project will make use of tunable oil droplets, paramagnetic beads, and 3D-printed microplastic particles, and in vitro models (collagen gels and PDMS microchannels) to study the ability of mouse bone marrow-derived DCs to transmigrate through constricted spaces while carrying large cargo. The aim is to understand how DCs are able to navigate complex tissue environments.

Objective

As immune sentinels, dendritic cells (DCs) must be able to ingest material and migrate to lymph nodes to present the processed antigen to T cells, and initiate the adaptive immune response, essential against pathogens or cancer. This means that DCs must be able to navigate through complex environments with this ingested material of varying physical characteristics. Preliminary data revealed that DCs deform and/or rotate large, ingested material to overcome occlusion from entering constriction points (transmigration). Additionally, there are instances of nuclear deformation and even migratory frustration, which reflect reported phenomena of DCs in vivo in mice. I propose to use a suite of fabricated particles and in vitro complex environments to test the ability of mouse bone marrow-derived dendritic cells to overcome physical obstacles with large cargos. The fabricated particles will include oil droplets with tunable deformability, paramagnetic particles, and 3D printed microplastics. The in vitro complex environments are collagen gels and PDMS microchannels where I can observe DCs with ingest particles attempting to through points of constriction. With this experimental set-up, I can measure the efficiency of transmigration, deformation or rotation of particles, as well as the force exerted on particles as a function of particle properties. Furthermore, I can observe the effect of particle manipulation on DC behavior and function, even if they never successfully transmigrate. This work will aim to answer how dendritic cells can migrate successfully with a wide range of materials, but also provide insight into the role of frustrated or trapped DCs that are observed in tissues, and particularly near tumors.

Fields of science (EuroSciVoc)

Keywords

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Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2024-PF-01

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Coordinator

INSTITUT CURIE
Net EU contribution
€ 242 260,56
Address
RUE D ULM 26
75231 Paris
France
Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
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Total cost
No data