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Bidirectional neuromuscular interface based on associative plasticity for stroke therapy during activities of daily living

Project description

Wearable device for stroke rehabilitation

Stroke is a leading cause of disability worldwide. The Neubond device offers wearable, autonomous therapy for stroke survivors by detecting muscle activity and delivering real-time stimulation to boost recovery. Using volition-induced paired associative stimulation (VIPAS), it promotes neuroplasticity without the need for complex setups. Early trials have shown improved motor function and reduced spasticity, supporting greater accessibility and patient compliance. The ERC-funded Neubond project will further develop the prototype, pursue regulatory approval, and conduct safety and usability testing. The aim is to support commercialisation and create spin-out companies. Neubond builds on insights from the ERC Synergy grant Natural BionicS, which focuses on bi-directional brain-muscle interfaces to restore movement.

Objective

Stroke is a leading cause of disability globally, with millions affected each year. A critical challenge in stroke recovery is the limited availability and intensity of rehabilitation therapies, which often fail to meet recommended guidelines. The neubond device, aims to address this by delivering autonomous, wearable therapy to stroke survivors during their daily activities. The device detects muscle activity through muscle signals and provides real-time stimulation to enhance motor recovery. By leveraging our novel volition induced paired associative stimulation (VIPAS) approach, the system stimulates neuroplasticity and facilitates muscle contractions, accelerating functional improvements without the need for complex setups or screen-based exercises. Initial trials have demonstrated significant improvements in motor function and usability, with a reduction in spasticity and increased range of motion. Our concept aligns with the unmet need for continuous, accessible rehabilitation, bridging the gap between clinical and home-based care. The device non-invasive, autonomous design enhances patient compliance, ensuring consistent therapy outside of scheduled sessions. The project leverages findings from the ERC Synergy grant Natural BionicS, focusing on bi-directional brain-muscle interfaces. The project aims to advance the prototype towards regulatory compliance, safety, and usability testing, ultimately driving commercialisation and spinout formation. Our device presents a high-gain potential, with significant cost savings for healthcare providers and enhanced quality of life for stroke survivors.

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HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants

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Call for proposal

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(opens in new window) ERC-2024-POC

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Host institution

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 150 000,00
Address
SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
SW7 2AZ London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
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Total cost

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Beneficiaries (1)

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