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Translational METabolomics for NEurodegenerative Diseases dIAgnosis and prognosis

Objective

The prevalence of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and frontotemporal dementia, continues to rise, partly due to increasing life expectancy. The diagnosis of these disorders remains a significant challenge due to overlapping symptoms, delayed recognition of early symptoms often mistaken for normal aging, and variability in symptom presentation across patients.
METNEDIA will tackle these challenges by proposing a new framework for the development of a diagnostic tool. METNEDIA will utilize metabolomic analysis and artificial intelligence to develop a diagnostic tool for the diagnosis of neurodegenerative diseases. A discovery phase will be initially performed using untargeted metabolomic approaches to identify most relevant biomarkers. The project will then develop of a diagnostic kit based on mass spectrometry and artificial intelligence for the diagnosis of widely diffuse neurodegenerative diseases. A multicenter validation of the kit will be also performed. Neurotoxic evaluation of molecules identified as relevant for each disease will be evaluated in vitro. Finally, bioinformatic and machine learning will be used to gaining insight on the biology of neurodegenerative disorders using in vitro and in vivo data.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges

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Call for proposal

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(opens in new window) HORIZON-MSCA-2024-SE-01

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Coordinator

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 205 410,00
Address
DUOMO 6
13100 Vercelli
Italy

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Region
Nord-Ovest Piemonte Vercelli
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (6)

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