Project description
The amyloid polymorphism’s code in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, present major health challenges due to protein misfolding and amyloid aggregation. However, the role of structural polymorphism is still largely unexplored. The EU-funded AMI-CryoML project will investigate modulators of amyloid aggregation and their effects on aggregation kinetics and polymorphism. It aims to collect and analyse data on known modulators, focusing on their chemical properties and mechanisms. The project will study how these modulators influence different phases of amyloid self-aggregation using ThT assays, and it will evaluate their efficacy on various amyloids, including prions, CsgA, and α-synuclein. It will use cryo-electron microscopy (CryoEM) to study structural polymorphisms, create the AmyloGraph database, and draw on ML to develop predictive models.
Objective
Neurodegenerative diseases such as Alzheimer's (AD), Parkinson’s (PD), and prion-related disorders pose major global health challenges due to their progressive nature and lack of effective treatments. Central to these conditions is the misfolding and aggregation of proteins into amyloid structures, which cause severe cellular damage. Despite advances in understanding amyloid aggregation, the role of structural polymorphism in these processes remains underexplored. This proposal aims to address this gap by investigating amyloid aggregation modulators and their effects on aggregation kinetics and polymorphism.
The project has five main objectives:
1. Data Collection on agregation modulators: Systematically gather and curate data on known modulators that impact amyloid aggregation, focusing on their chemical properties and mechanisms.
2. Aggregation kinetics studies: Study the impact of selected modulators on the kinetics of amyloid self-aggregation using ThT assays. This includes analyzing how modulators influence different phases of aggregation and testing their efficacy on a range of amyloids, including prions, CsgA, and α-synuclein.
3. Study structural polymorphisms via CryoEM: Utilize Cryo-Electron Microscopy (CryoEM) to resolve and map the structural polymorphs of amyloids under various conditions. Providing insights into impact of modulators on structural polymorphism and aggregation kinetics.
4. AmyloGraph database enhancement: Develop a new module for the AmyloGraph database to store and analyze data on modulators, aggregation kinetics, and structural polymorphisms.
5. Development of ML models: Leverage machine learning to develop predictive and generative models to forecast amyloid aggregation kinetics and modulator effects, incorporating structural polymorphisms, and generate new modulators targeting specific polymorphic forms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences computer and information sciences databases
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine neurology parkinson
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2024-TALENTS-02
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
01513 Vilnius
Lithuania
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.