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PREVENT AND BYPASS - A VISION TO PROTECT BLOOD CELLS FROM ADVERSE IMMUNE RESPONSES

Ziel

PROTECT: Advancing Blood Cell Protection from Immune Attack
This ERC Advanced Grant project, PROTECT, aims to overcome challenges in preventing adverse immune responses against blood cells induced by essential medical interventions: vaccination, transfusion, and thrombosis prophylaxis. Despite their life-saving potential, these therapies can trigger rare but severe complications due to antibody-mediated immune activation.
PROTECT addresses this through two interconnected challenges: PREVENT, focusing on adenovirus vector vaccine safety by elucidating the mechanisms behind vaccine-induced immune thrombocytopenia and thrombosis (VITT); and BYPASS, aiming to enable safe transfusions for immunized patients by enzymatically removing antigenic proteins from donor blood cells.
PREVENT will investigate the specific adenoviral components triggering the anti-PF4 response, utilizing advanced proteomics, genetics, and humanized mouse models. BYPASS will leverage innovative enzyme engineering and targeted protein degradation to modify blood products in situ, offering a paradigm shift in transfusion medicine.
By integrating mechanistic insights with translational approaches, PROTECT strives to develop preventative and corrective strategies, ultimately preserving public trust in life-saving medical practices and establishing a unique human model system for alloimmunization research. This ambitious program promises high-gain potential with lasting impact on patient care and blood product safety.

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Schlüsselbegriffe

Programm/Programme

Thema/Themen

Finanzierungsplan

HORIZON-ERC - HORIZON ERC Grants

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Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) ERC-2025-ADG

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Gastgebende Einrichtung

UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS
Netto-EU-Beitrag
€ 2 500 000,00
Adresse
FLEISCHMANNSTRASSE 8
17489 Greifswald
Deutschland
Region
Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
Keine Daten

Begünstigte (1)