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Stem cells for Biological Assays of Novel drugs and prediCtive toxiCology (StemBANCC)

Ziel

StemBANCC, comprising internationally renowned investigators, is ideally positioned to deliver a unique European biorepository and drug discovery pipeline based upon human induced pluripotent stem cells (hiPSC). This unrivalled opportunity will address the pressing therapeutic need in neurodegeneration, neurodysfunction and diabetes. We have immediate access to richly phenotyped subjects with a wealth of clinical data. Furthermore our cohorts include genetic and genome data, allowing us to carefully select subjects for hiPSC based disease model development. This clinical-genetic stratification is essential to ensure that cellular models display disease and therapy relevant phenotypes. hiPSC reprogramming is undertaken by an internationally respected centre, providing robust, reliable and timely delivery of hiPSCs; ensures the biorepository only houses quality assured hiPSC lines; and reduces unwanted variability in assays. We have leading experts in hiPSC differentiation, providing protocols with over 99% efficiency in producing cortical excitatory neurons and cardiomyocytes, which following up-scaling will meet demands of high throughput assays. StemBANCC will deliver a comprehensive ‘omics’ dataset on over 1500 stem cell lines. This includes cells taken at different lineage stages, after therapeutic challenge, monogenic and complex variants, and with matched isogenic controls. The integration of this network/pathway data will define core etiopathological processes, therapeutic generality, reveal on- and off-target effects, allow candidate therapeutic repositioning and decouple tolerance and toxicity pathways. The large-scale integrated datasets then directly guide the disease specific targeted assays, designed to maximize utility in low and high- through compound screening programs. Assay development undertaken by the StemBANCC proposed central test facility thereby provides the final component of our hiPSC platform for drug discovery, development and safety.

Wissenschaftliches Gebiet (EuroSciVoc)

CORDIS klassifiziert Projekte mit EuroSciVoc, einer mehrsprachigen Taxonomie der Wissenschaftsbereiche, durch einen halbautomatischen Prozess, der auf Verfahren der Verarbeitung natürlicher Sprache beruht.

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Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

IMI-JU-04-2011
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Koordinator

F. HOFFMANN-LA ROCHE AG
EU-Beitrag
Keine Daten
Adresse
GRENZACHERSTRASSE 124
4070 Basel
Schweiz

Auf der Karte ansehen
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Hauptforscher
Martin Graf (-)
Links
Gesamtkosten
Keine Daten

Beteiligte (37)

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Letzte Aktualisierung: 10 Februar 2022

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/115439/de

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