ITCC Pediatric Preclinical POC Platform – Sofia ref.: 116064

Deliverables

Websites, patent fillings, videos etc. (2)

Final draft and Submission of a paper for publication

Migration

International scientific symposium on : “Preclinicalevaluation in pediatric oncology drug development”

Migration

Publications

Thesis dissertations (1)

Molecular and preclinical evaluation of patient-derived orthotopic xenograft models of pediatric brain tumors

Author(s): Sebastian Brabetz
Published in: 2018

Peer reviewed articles (7)

A biobank of patient-derived pediatric brain tumor models

Author(s): Sebastian Brabetz, Sarah E. S. Leary, Susanne N. Gröbner, Madison W. Nakamoto, Huriye Şeker-Cin, Emily J. Girard, Bonnie Cole, Andrew D. Strand, Karina L. Bloom, Volker Hovestadt, Norman L. Mack, Fiona Pakiam, Benjamin Schwalm, Andrey Korshunov, Gnana Prakash Balasubramanian, Paul A. Northcott, Kyle D. Pedro, Joyoti Dey, Stacey Hansen, Sally Ditzler, Peter Lichter, Lukas Chavez, David T. W. Jone
Published in: Nature Medicine, Issue 24/11, 2018, Page(s) 1752-1761, ISSN 1078-8956
DOI: 10.1038/s41591-018-0207-3

PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH

Author(s): Sebastian Brabetz, Susanne N Groebner, Natalie Jaeger, Till Milde, Jonas Ecker, Florian Selt, Olaf Witt, Jessica M Rusert, Jan Koster, Sarah E Leary, Xiao-Nan Li, Robert J Wechsler-Reya, James M Olson, Stefan M Pfister, Marcel Kool
Published in: Neuro-Oncology, Issue 20/suppl_2, 2018, Page(s) i155-i155, ISSN 1522-8517
DOI: 10.1093/neuonc/noy059.574

Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors

Author(s): Natalie Timme, Youjia Han, Shuai Liu, Hailemichael O. Yosief, Heathcliff Dorado García, Yi Bei, Filippos Klironomos, Ian C. MacArthur, Annabell Szymansky, Jennifer von Stebut, Victor Bardinet, Constantin Dohna, Annette Künkele, Jana Rolff, Patrick Hundsdörfer, Andrej Lissat, Georg Seifert, Angelika Eggert, Johannes H. Schulte, Wei Zhang, Anton G. Henssen
Published in: Translational Oncology, Issue 13/2, 2020, Page(s) 221-232, ISSN 1936-5233
DOI: 10.1016/j.tranon.2019.09.013

ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Author(s): Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi
Published in: Journal of Experimental & Clinical Cancer Research, Issue 38/1, 2019, ISSN 1756-9966
DOI: 10.1186/s13046-019-1506-3

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma

Author(s): Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
DOI: 10.1186/s40478-019-0775-6

Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice

Author(s): Hannah Kohler, Soeren Latteyer, Georg Sebastian Hönes, Sarah Theurer, Xiao-Hui Liao, Sandra Christoph, Denise Zwanziger, Johannes H. Schulte, Jukka Kero, Hendrik Undeutsch, Samuel Refetoff, Kurt W. Schmid, Dagmar Führer, Lars C. Moeller
Published in: Thyroid, Issue 29/10, 2019, Page(s) 1438-1446, ISSN 1050-7256
DOI: 10.1089/thy.2018.0526

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma

Author(s): Youjia Han, Sven Lindner, Yi Bei, Heathcliff Dorado Garcia, Natalie Timme, Kristina Althoff, Andrea Odersky, Alexander Schramm, Andrej Lissat, Annette Künkele, Hedwig E. Deubzer, Angelika Eggert, Johannes H. Schulte, Anton G. Henssen
Published in: Cancer Letters, Issue 445, 2019, Page(s) 24-33, ISSN 0304-3835
DOI: 10.1016/j.canlet.2018.12.012