Deliverables Websites, patent fillings, videos etc. (2) Final draft and Submission of a paper for publication Migration International scientific symposium on : “Preclinicalevaluation in pediatric oncology drug development” Migration Publications Peer reviewed articles (16) Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity Author(s): Gabriele Manzella, Leonie D. Schreck, Willemijn B. Breunis, Jan Molenaar, Hans Merks, Frederic G. Barr, Wenyue Sun, Michaela Römmele, Luduo Zhang, Joelle Tchinda, Quy A. Ngo, Peter Bode, Olivier Delattre, Didier Surdez, Bharat Rekhi, Felix K. Niggli, Beat W. Schäfer, Marco Wachtel Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-18388-7 Targeting fibroblast growth factor receptors to combat aggressive ependymoma Author(s): Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, Laemmerer A, Gabler L, Pirker C, Donson AM, Bannauer P, Korbel P, Jaunecker CN, Hübner JM, Mayr L, Madlener S, Schmook MT, Ricken G, Maaß K, Grusch M, Holzmann K, Grasl-Kraupp B, Spiegl-Kreinecker S, Hsu J, Dorfer C, Rössler K, Azizi AA, Foreman NK, Peyrl A, Haberler C, Czech T, Slavc I, Filbin MG, Pajtler KW, Kool M, Ber Published in: Acta neuropathologica communications, Issue 2021 Aug; 142(2), 2021, Page(s) 339-360, ISSN 0001-6322 Publisher: Springer Verlag DOI: 10.1007/s00401-021-02327-x Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers Author(s): Nil A. Schubert, Caitlin D. Lowery, Guillaume Bergthold, Jan Koster, Thomas F. Eleveld, Ana Rodríguez, David T.W. Jones, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Hubert N. Caron, Jan J. Molenaar Published in: European Journal of Cancer, Issue 130, 2020, Page(s) 168-181, ISSN 0959-8049 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.ejca.2020.01.027 Crossing Oceans: Preclinical Collaboration to Improve Pediatric Drug Development Author(s): Gregory Reaman, Louis Stancato, Gilles Vassal, John M. Maris Published in: American Society of Clinical Oncology Educational Book, Issue 40, 2020, Page(s) 409-416, ISSN 1548-8748 Publisher: American Society of Clinical Oncology DOI: 10.1200/edbk_278893 International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer Author(s): Vassal, G. Houghton, P. J. Pfister, S. M. Smith, M. A. Caron, H. N. Li, X. N. Shields, D. J. Witt, O. Molenaar, J. J. Colombetti, S. Schuler, J. Stancato, L. F. Published in: Mol Cancer Ther, Issue Volume 20, 2021, Page(s) 1462–8, ISSN 1535-7163 Publisher: American Association for Cancer Research DOI: 10.1158/1535-7163.mct-20-0394 Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas Author(s): Helena Castillo-Ecija, Guillem Pascual-Pasto, Sara Perez-Jaume, Claudia Resa-Pares, Monica Vila-Ubach, Carles Monterrubio, Ana Jimenez-Cabaco, Merce Baulenas-Farres, Oscar Muñoz-Aznar, Noelia Salvador, Maria Cuadrado-Vilanova, Nagore G. Olaciregui, Leire Balaguer-Lluna, Victor Burgueño, Francisco J. Vicario, Alejandro Manzanares, Alicia Castañeda, Vicente Santa-Maria, Ofelia Cruz, Veronica Celi Published in: Journal of Pathology – clinical research, Issue Volume 7, Issu 4, July 2021, 2021, Page(s) 338-349, ISSN 2056-4538 Publisher: Wiley DOI: 10.1002/cjp2.210 Integrated molecular characterization of patient-derived models reveals therapeutic strategies for treating CIC-DUX4 sarcoma Author(s): Carrabotta M, Laginestra MA, Durante G, Mancarella C, Landuzzi L, Parra A, Ruzzi F, Toracchio L, De Feo A, Giusti V, Pasello M, Righi A, Lollini PL, Palmerini E, Donatii DM, Manara MC, Scotlandi K. Published in: Cancer Research, Issue 2022 Feb 15;82(4), 2021, Page(s) 708-720, ISSN 1538-7445 Publisher: AACR DOI: 10.1158/0008-5472.can-21-1222 Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for pediatric solid malignancies Author(s): Kaylee M. Keller; Apurva Gopisetty; Dan Luedtke; Jan Koster; Nil A. Schubert; Ana Rodríguez; Sander R. van Hooff; Damian Stichel; Emmy M. Dolman; Gilles Vassal; Stefan M. Pfister; Hubert N. Caron; Louis F. Stancato; Jan J. Molenaar; Natalie Jäger; Marcel Kool Published in: Eur J Cancer, Issue Dec 25, 2021; Volume 162, February 2022, 2021, Page(s) Pages 107-117, ISSN 0959-8049 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.ejca.2021.11.030 A biobank of patient-derived pediatric brain tumor models Author(s): Sebastian Brabetz, Sarah E. S. Leary, Susanne N. Gröbner, Madison W. Nakamoto, Huriye Şeker-Cin, Emily J. Girard, Bonnie Cole, Andrew D. Strand, Karina L. Bloom, Volker Hovestadt, Norman L. Mack, Fiona Pakiam, Benjamin Schwalm, Andrey Korshunov, Gnana Prakash Balasubramanian, Paul A. Northcott, Kyle D. Pedro, Joyoti Dey, Stacey Hansen, Sally Ditzler, Peter Lichter, Lukas Chavez, David T. W. Jone Published in: Nature Medicine, Issue 24/11, 2018, Page(s) 1752-1761, ISSN 1078-8956 Publisher: Nature Publishing Group DOI: 10.1038/s41591-018-0207-3 PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH Author(s): Sebastian Brabetz, Susanne N Groebner, Natalie Jaeger, Till Milde, Jonas Ecker, Florian Selt, Olaf Witt, Jessica M Rusert, Jan Koster, Sarah E Leary, Xiao-Nan Li, Robert J Wechsler-Reya, James M Olson, Stefan M Pfister, Marcel Kool Published in: Neuro-Oncology, Issue 20/suppl_2, 2018, Page(s) i155-i155, ISSN 1522-8517 Publisher: Duke University Press DOI: 10.1093/neuonc/noy059.574 Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors Author(s): Natalie Timme, Youjia Han, Shuai Liu, Hailemichael O. Yosief, Heathcliff Dorado García, Yi Bei, Filippos Klironomos, Ian C. MacArthur, Annabell Szymansky, Jennifer von Stebut, Victor Bardinet, Constantin Dohna, Annette Künkele, Jana Rolff, Patrick Hundsdörfer, Andrej Lissat, Georg Seifert, Angelika Eggert, Johannes H. Schulte, Wei Zhang, Anton G. Henssen Published in: Translational Oncology, Issue 13/2, 2020, Page(s) 221-232, ISSN 1936-5233 Publisher: Neoplasia Press DOI: 10.1016/j.tranon.2019.09.013 ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity Author(s): Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi Published in: Journal of Experimental & Clinical Cancer Research, Issue 38/1, 2019, ISSN 1756-9966 Publisher: J Exp Clin Cancer Res DOI: 10.1186/s13046-019-1506-3 TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma Author(s): Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.1186/s40478-019-0775-6 Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice Author(s): Hannah Kohler, Soeren Latteyer, Georg Sebastian Hönes, Sarah Theurer, Xiao-Hui Liao, Sandra Christoph, Denise Zwanziger, Johannes H. Schulte, Jukka Kero, Hendrik Undeutsch, Samuel Refetoff, Kurt W. Schmid, Dagmar Führer, Lars C. Moeller Published in: Thyroid, Issue 29/10, 2019, Page(s) 1438-1446, ISSN 1050-7256 Publisher: Mary Ann Liebert Inc. DOI: 10.1089/thy.2018.0526 Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma Author(s): Youjia Han, Sven Lindner, Yi Bei, Heathcliff Dorado Garcia, Natalie Timme, Kristina Althoff, Andrea Odersky, Alexander Schramm, Andrej Lissat, Annette Künkele, Hedwig E. Deubzer, Angelika Eggert, Johannes H. Schulte, Anton G. Henssen Published in: Cancer Letters, Issue 445, 2019, Page(s) 24-33, ISSN 0304-3835 Publisher: Elsevier BV DOI: 10.1016/j.canlet.2018.12.012 Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma Author(s): Johannes Gojo, Bernhard Englinger, Li Jiang, Jens M. Hübner, McKenzie L. Shaw, Olivia A. Hack, Sibylle Madlener, Dominik Kirchhofer, Ilon Liu, Jason Pyrdol, Volker Hovestadt, Emanuele Mazzola, Nathan D. Mathewson, Maria Trissal, Daniela Lötsch, Christian Dorfer, Christine Haberler, Angela Halfmann, Lisa Mayr, Andreas Peyrl, Rene Geyeregger, Benjamin Schwalm, Monica Mauermann, Kristian W. Pajtler Published in: Cancer Cell, Issue 38/1, 2020, Page(s) 44-59.e9, ISSN 1535-6108 Publisher: Cell Press DOI: 10.1016/j.ccell.2020.06.004 Book chapters (1) Ewing Sarcoma PDX Models Author(s): Didier Surdez, Lorena Landuzzi, Katia Scotlandi, Maria Cristina Manara Published in: Ewing Sarcoma - Methods and Protocols, Issue 2226, 2021, Page(s) 223-242, ISBN 978-1-0716-1019-0 Publisher: Springer US DOI: 10.1007/978-1-0716-1020-6_18 Thesis dissertations (1) Molecular and preclinical evaluation of patient-derived orthotopic xenograft models of pediatric brain tumors Author(s): Sebastian Brabetz Published in: 2018 Publisher: Univesity of Heidelberg Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
