Risultati finali Websites, patent fillings, videos etc. (2) Final draft and Submission of a paper for publication Migration International scientific symposium on : “Preclinicalevaluation in pediatric oncology drug development” Migration Pubblicazioni Peer reviewed articles (17) Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity Autori: Gabriele Manzella, Leonie D. Schreck, Willemijn B. Breunis, Jan Molenaar, Hans Merks, Frederic G. Barr, Wenyue Sun, Michaela Römmele, Luduo Zhang, Joelle Tchinda, Quy A. Ngo, Peter Bode, Olivier Delattre, Didier Surdez, Bharat Rekhi, Felix K. Niggli, Beat W. Schäfer, Marco Wachtel Pubblicato in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Editore: Nature Publishing Group DOI: 10.1038/s41467-020-18388-7 Targeting fibroblast growth factor receptors to combat aggressive ependymoma Autori: Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, Laemmerer A, Gabler L, Pirker C, Donson AM, Bannauer P, Korbel P, Jaunecker CN, Hübner JM, Mayr L, Madlener S, Schmook MT, Ricken G, Maaß K, Grusch M, Holzmann K, Grasl-Kraupp B, Spiegl-Kreinecker S, Hsu J, Dorfer C, Rössler K, Azizi AA, Foreman NK, Peyrl A, Haberler C, Czech T, Slavc I, Filbin MG, Pajtler KW, Kool M, Ber Pubblicato in: Acta neuropathologica communications, Issue 2021 Aug; 142(2), 2021, Page(s) 339-360, ISSN 0001-6322 Editore: Springer Verlag DOI: 10.1007/s00401-021-02327-x Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers Autori: Nil A. Schubert, Caitlin D. Lowery, Guillaume Bergthold, Jan Koster, Thomas F. Eleveld, Ana Rodríguez, David T.W. Jones, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Hubert N. Caron, Jan J. Molenaar Pubblicato in: European Journal of Cancer, Issue 130, 2020, Page(s) 168-181, ISSN 0959-8049 Editore: Pergamon Press Ltd. DOI: 10.1016/j.ejca.2020.01.027 Crossing Oceans: Preclinical Collaboration to Improve Pediatric Drug Development Autori: Gregory Reaman, Louis Stancato, Gilles Vassal, John M. Maris Pubblicato in: American Society of Clinical Oncology Educational Book, Issue 40, 2020, Page(s) 409-416, ISSN 1548-8748 Editore: American Society of Clinical Oncology DOI: 10.1200/edbk_278893 International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer Autori: Vassal, G. Houghton, P. J. Pfister, S. M. Smith, M. A. Caron, H. N. Li, X. N. Shields, D. J. Witt, O. Molenaar, J. J. Colombetti, S. Schuler, J. Stancato, L. F. Pubblicato in: Mol Cancer Ther, Issue Volume 20, 2021, Page(s) 1462–8, ISSN 1535-7163 Editore: American Association for Cancer Research DOI: 10.1158/1535-7163.mct-20-0394 Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas Autori: Helena Castillo-Ecija, Guillem Pascual-Pasto, Sara Perez-Jaume, Claudia Resa-Pares, Monica Vila-Ubach, Carles Monterrubio, Ana Jimenez-Cabaco, Merce Baulenas-Farres, Oscar Muñoz-Aznar, Noelia Salvador, Maria Cuadrado-Vilanova, Nagore G. Olaciregui, Leire Balaguer-Lluna, Victor Burgueño, Francisco J. Vicario, Alejandro Manzanares, Alicia Castañeda, Vicente Santa-Maria, Ofelia Cruz, Veronica Celi Pubblicato in: Journal of Pathology – clinical research, Issue Volume 7, Issu 4, July 2021, 2021, Page(s) 338-349, ISSN 2056-4538 Editore: Wiley DOI: 10.1002/cjp2.210 Integrated molecular characterization of patient-derived models reveals therapeutic strategies for treating CIC-DUX4 sarcoma Autori: Carrabotta M, Laginestra MA, Durante G, Mancarella C, Landuzzi L, Parra A, Ruzzi F, Toracchio L, De Feo A, Giusti V, Pasello M, Righi A, Lollini PL, Palmerini E, Donatii DM, Manara MC, Scotlandi K. Pubblicato in: Cancer Research, Issue 2022 Feb 15;82(4), 2021, Page(s) 708-720, ISSN 1538-7445 Editore: AACR DOI: 10.1158/0008-5472.can-21-1222 Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for pediatric solid malignancies Autori: Kaylee M. Keller; Apurva Gopisetty; Dan Luedtke; Jan Koster; Nil A. Schubert; Ana Rodríguez; Sander R. van Hooff; Damian Stichel; Emmy M. Dolman; Gilles Vassal; Stefan M. Pfister; Hubert N. Caron; Louis F. Stancato; Jan J. Molenaar; Natalie Jäger; Marcel Kool Pubblicato in: Eur J Cancer, Issue Dec 25, 2021; Volume 162, February 2022, 2021, Page(s) Pages 107-117, ISSN 0959-8049 Editore: Pergamon Press Ltd. DOI: 10.1016/j.ejca.2021.11.030 A biobank of patient-derived pediatric brain tumor models Autori: Sebastian Brabetz, Sarah E. S. Leary, Susanne N. Gröbner, Madison W. Nakamoto, Huriye Şeker-Cin, Emily J. Girard, Bonnie Cole, Andrew D. Strand, Karina L. Bloom, Volker Hovestadt, Norman L. Mack, Fiona Pakiam, Benjamin Schwalm, Andrey Korshunov, Gnana Prakash Balasubramanian, Paul A. Northcott, Kyle D. Pedro, Joyoti Dey, Stacey Hansen, Sally Ditzler, Peter Lichter, Lukas Chavez, David T. W. Jone Pubblicato in: Nature Medicine, Issue 24/11, 2018, Page(s) 1752-1761, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-018-0207-3 PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH Autori: Sebastian Brabetz, Susanne N Groebner, Natalie Jaeger, Till Milde, Jonas Ecker, Florian Selt, Olaf Witt, Jessica M Rusert, Jan Koster, Sarah E Leary, Xiao-Nan Li, Robert J Wechsler-Reya, James M Olson, Stefan M Pfister, Marcel Kool Pubblicato in: Neuro-Oncology, Issue 20/suppl_2, 2018, Page(s) i155-i155, ISSN 1522-8517 Editore: Duke University Press DOI: 10.1093/neuonc/noy059.574 Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors Autori: Natalie Timme, Youjia Han, Shuai Liu, Hailemichael O. Yosief, Heathcliff Dorado García, Yi Bei, Filippos Klironomos, Ian C. MacArthur, Annabell Szymansky, Jennifer von Stebut, Victor Bardinet, Constantin Dohna, Annette Künkele, Jana Rolff, Patrick Hundsdörfer, Andrej Lissat, Georg Seifert, Angelika Eggert, Johannes H. Schulte, Wei Zhang, Anton G. Henssen Pubblicato in: Translational Oncology, Issue 13/2, 2020, Page(s) 221-232, ISSN 1936-5233 Editore: Neoplasia Press DOI: 10.1016/j.tranon.2019.09.013 ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity Autori: Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi Pubblicato in: Journal of Experimental & Clinical Cancer Research, Issue 38/1, 2019, ISSN 1756-9966 Editore: J Exp Clin Cancer Res DOI: 10.1186/s13046-019-1506-3 TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma Autori: Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger Pubblicato in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960 Editore: BioMed Central DOI: 10.1186/s40478-019-0775-6 Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice Autori: Hannah Kohler, Soeren Latteyer, Georg Sebastian Hönes, Sarah Theurer, Xiao-Hui Liao, Sandra Christoph, Denise Zwanziger, Johannes H. Schulte, Jukka Kero, Hendrik Undeutsch, Samuel Refetoff, Kurt W. Schmid, Dagmar Führer, Lars C. Moeller Pubblicato in: Thyroid, Issue 29/10, 2019, Page(s) 1438-1446, ISSN 1050-7256 Editore: Mary Ann Liebert Inc. DOI: 10.1089/thy.2018.0526 Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma Autori: Youjia Han, Sven Lindner, Yi Bei, Heathcliff Dorado Garcia, Natalie Timme, Kristina Althoff, Andrea Odersky, Alexander Schramm, Andrej Lissat, Annette Künkele, Hedwig E. Deubzer, Angelika Eggert, Johannes H. Schulte, Anton G. Henssen Pubblicato in: Cancer Letters, Issue 445, 2019, Page(s) 24-33, ISSN 0304-3835 Editore: Elsevier BV DOI: 10.1016/j.canlet.2018.12.012 Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma Autori: Johannes Gojo, Bernhard Englinger, Li Jiang, Jens M. Hübner, McKenzie L. Shaw, Olivia A. Hack, Sibylle Madlener, Dominik Kirchhofer, Ilon Liu, Jason Pyrdol, Volker Hovestadt, Emanuele Mazzola, Nathan D. Mathewson, Maria Trissal, Daniela Lötsch, Christian Dorfer, Christine Haberler, Angela Halfmann, Lisa Mayr, Andreas Peyrl, Rene Geyeregger, Benjamin Schwalm, Monica Mauermann, Kristian W. Pajtler Pubblicato in: Cancer Cell, Issue 38/1, 2020, Page(s) 44-59.e9, ISSN 1535-6108 Editore: Cell Press DOI: 10.1016/j.ccell.2020.06.004 Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours Autori: Nil A. Schubert, Celine Y. Chen, Ana Rodríguez, Jan Koster, Michele Dowless, Stefan M. Pfister, David J. Shields, Louis F. Stancato, Gilles Vassal, Hubert N. Caron, Marlinde L. van den Boogaard, Anton G. Henssen, Jan J. Molenaar Pubblicato in: European Journal of Cancer, Issue 170 (2022), 2022, Page(s) 196 – 208, ISSN 0959-8049 Editore: Pergamon Press Ltd. DOI: 10.1016/j.ejca.2022.04.028 Book chapters (1) Ewing Sarcoma PDX Models Autori: Didier Surdez, Lorena Landuzzi, Katia Scotlandi, Maria Cristina Manara Pubblicato in: Ewing Sarcoma - Methods and Protocols, Issue 2226, 2021, Page(s) 223-242, ISBN 978-1-0716-1019-0 Editore: Springer US DOI: 10.1007/978-1-0716-1020-6_18 Thesis dissertations (1) Molecular and preclinical evaluation of patient-derived orthotopic xenograft models of pediatric brain tumors Autori: Sebastian Brabetz Pubblicato in: 2018 Editore: Univesity of Heidelberg È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
