ITCC Pediatric Preclinical POC Platform – Sofia ref.: 116064

Informacje na temat projektu

ITCC-P4

Identyfikator umowy o grant: 116064

DOI

10.3030/116064

Projekt został zamknięty

Data podpisania przez KE 18 Maja 2017

Data rozpoczęcia 1 Stycznia 2017

Data zakończenia 31 Grudnia 2023

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 19 930 472,94

Wkład UE

€ 7 370 000,00

Koordynowany przez

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (3)

Final draft and Submission of a paper for publication

Migration

Launch of the sustainability platform

Migration

International scientific symposium on : “Preclinicalevaluation in pediatric oncology drug development”

Migration

Publikacje

Peer reviewed articles (18)

Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity

Autorzy: Gabriele Manzella, Leonie D. Schreck, Willemijn B. Breunis, Jan Molenaar, Hans Merks, Frederic G. Barr, Wenyue Sun, Michaela Römmele, Luduo Zhang, Joelle Tchinda, Quy A. Ngo, Peter Bode, Olivier Delattre, Didier Surdez, Bharat Rekhi, Felix K. Niggli, Beat W. Schäfer, Marco Wachtel
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-18388-7

Targeting fibroblast growth factor receptors to combat aggressive ependymoma

Autorzy: Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, Laemmerer A, Gabler L, Pirker C, Donson AM, Bannauer P, Korbel P, Jaunecker CN, Hübner JM, Mayr L, Madlener S, Schmook MT, Ricken G, Maaß K, Grusch M, Holzmann K, Grasl-Kraupp B, Spiegl-Kreinecker S, Hsu J, Dorfer C, Rössler K, Azizi AA, Foreman NK, Peyrl A, Haberler C, Czech T, Slavc I, Filbin MG, Pajtler KW, Kool M, Ber
Opublikowane w: Acta neuropathologica communications, Numer 2021 Aug; 142(2), 2021, Strona(/y) 339-360, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-021-02327-x

Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers

Autorzy: Nil A. Schubert, Caitlin D. Lowery, Guillaume Bergthold, Jan Koster, Thomas F. Eleveld, Ana Rodríguez, David T.W. Jones, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Hubert N. Caron, Jan J. Molenaar
Opublikowane w: European Journal of Cancer, Numer 130, 2020, Strona(/y) 168-181, ISSN 0959-8049
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2020.01.027

Crossing Oceans: Preclinical Collaboration to Improve Pediatric Drug Development

Autorzy: Gregory Reaman, Louis Stancato, Gilles Vassal, John M. Maris
Opublikowane w: American Society of Clinical Oncology Educational Book, Numer 40, 2020, Strona(/y) 409-416, ISSN 1548-8748
Wydawca: American Society of Clinical Oncology
DOI: 10.1200/edbk_278893

International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer

Autorzy: Vassal, G. Houghton, P. J. Pfister, S. M. Smith, M. A. Caron, H. N. Li, X. N. Shields, D. J. Witt, O. Molenaar, J. J. Colombetti, S. Schuler, J. Stancato, L. F.
Opublikowane w: Mol Cancer Ther, Numer Volume 20, 2021, Strona(/y) 1462–8, ISSN 1535-7163
Wydawca: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-20-0394

Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas

Autorzy: Helena Castillo-Ecija, Guillem Pascual-Pasto, Sara Perez-Jaume, Claudia Resa-Pares, Monica Vila-Ubach, Carles Monterrubio, Ana Jimenez-Cabaco, Merce Baulenas-Farres, Oscar Muñoz-Aznar, Noelia Salvador, Maria Cuadrado-Vilanova, Nagore G. Olaciregui, Leire Balaguer-Lluna, Victor Burgueño, Francisco J. Vicario, Alejandro Manzanares, Alicia Castañeda, Vicente Santa-Maria, Ofelia Cruz, Veronica Celi
Opublikowane w: Journal of Pathology – clinical research, Numer Volume 7, Issu 4, July 2021, 2021, Strona(/y) 338-349, ISSN 2056-4538
Wydawca: Wiley
DOI: 10.1002/cjp2.210

Integrated molecular characterization of patient-derived models reveals therapeutic strategies for treating CIC-DUX4 sarcoma

Autorzy: Carrabotta M, Laginestra MA, Durante G, Mancarella C, Landuzzi L, Parra A, Ruzzi F, Toracchio L, De Feo A, Giusti V, Pasello M, Righi A, Lollini PL, Palmerini E, Donatii DM, Manara MC, Scotlandi K.
Opublikowane w: Cancer Research, Numer 2022 Feb 15;82(4), 2021, Strona(/y) 708-720, ISSN 1538-7445
Wydawca: AACR
DOI: 10.1158/0008-5472.can-21-1222

Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput <i>in vivo</i> testing

Autorzy: Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Ol
Opublikowane w: Cancer Research, Numer 83, 2023, Strona(/y) 234-234, ISSN 1538-7445
Wydawca: AACR
DOI: 10.1158/1538-7445.am2023-234

Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for pediatric solid malignancies

Autorzy: Kaylee M. Keller; Apurva Gopisetty; Dan Luedtke; Jan Koster; Nil A. Schubert; Ana Rodríguez; Sander R. van Hooff; Damian Stichel; Emmy M. Dolman; Gilles Vassal; Stefan M. Pfister; Hubert N. Caron; Louis F. Stancato; Jan J. Molenaar; Natalie Jäger; Marcel Kool
Opublikowane w: Eur J Cancer, Numer Dec 25, 2021; Volume 162, February 2022, 2021, Strona(/y) Pages 107-117, ISSN 0959-8049
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2021.11.030

Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models

Autorzy: Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir, Alexandra Saint-Charles, Justyna Wierzbinska, Andreas Schlicker, Richard Volckmann, Danny Zwijnenburg, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Christina Guttke, Maureen M. Hattersley, Frédéric Colland, Ashley Strougo, María José Guillén, Louis
Opublikowane w: Cancer Research, Numer 83, 2023, Strona(/y) 3571-3571, ISSN 1538-7445
Wydawca: AACR
DOI: 10.1158/1538-7445.am2023-3571

A biobank of patient-derived pediatric brain tumor models

Autorzy: Sebastian Brabetz, Sarah E. S. Leary, Susanne N. Gröbner, Madison W. Nakamoto, Huriye Şeker-Cin, Emily J. Girard, Bonnie Cole, Andrew D. Strand, Karina L. Bloom, Volker Hovestadt, Norman L. Mack, Fiona Pakiam, Benjamin Schwalm, Andrey Korshunov, Gnana Prakash Balasubramanian, Paul A. Northcott, Kyle D. Pedro, Joyoti Dey, Stacey Hansen, Sally Ditzler, Peter Lichter, Lukas Chavez, David T. W. Jone
Opublikowane w: Nature Medicine, Numer 24/11, 2018, Strona(/y) 1752-1761, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-018-0207-3

PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH

Autorzy: Sebastian Brabetz, Susanne N Groebner, Natalie Jaeger, Till Milde, Jonas Ecker, Florian Selt, Olaf Witt, Jessica M Rusert, Jan Koster, Sarah E Leary, Xiao-Nan Li, Robert J Wechsler-Reya, James M Olson, Stefan M Pfister, Marcel Kool
Opublikowane w: Neuro-Oncology, Numer 20/suppl_2, 2018, Strona(/y) i155-i155, ISSN 1522-8517
Wydawca: Duke University Press
DOI: 10.1093/neuonc/noy059.574

Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors

Autorzy: Natalie Timme, Youjia Han, Shuai Liu, Hailemichael O. Yosief, Heathcliff Dorado García, Yi Bei, Filippos Klironomos, Ian C. MacArthur, Annabell Szymansky, Jennifer von Stebut, Victor Bardinet, Constantin Dohna, Annette Künkele, Jana Rolff, Patrick Hundsdörfer, Andrej Lissat, Georg Seifert, Angelika Eggert, Johannes H. Schulte, Wei Zhang, Anton G. Henssen
Opublikowane w: Translational Oncology, Numer 13/2, 2020, Strona(/y) 221-232, ISSN 1936-5233
Wydawca: Neoplasia Press
DOI: 10.1016/j.tranon.2019.09.013

ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Autorzy: Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi
Opublikowane w: Journal of Experimental & Clinical Cancer Research, Numer 38/1, 2019, ISSN 1756-9966
Wydawca: J Exp Clin Cancer Res
DOI: 10.1186/s13046-019-1506-3

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma

Autorzy: Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger
Opublikowane w: Acta Neuropathologica Communications, Numer 7/1, 2019, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-019-0775-6

Abstract 3524: Pharmacological characterization of pediatric brain tumor PDX models in a single mouse trial format

Autorzy: Eva Oswald, Dorothee Lenhard, Kanstantsin Lashuk, Stefan Pfister, Louis Stancato, Julia Schueler
Opublikowane w: Cancer Research, Numer 83, 2023, Strona(/y) 3524-3524, ISSN 1538-7445
Wydawca: AACR
DOI: 10.1158/1538-7445.am2023-3524

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Autorzy: Johannes Gojo, Bernhard Englinger, Li Jiang, Jens M. Hübner, McKenzie L. Shaw, Olivia A. Hack, Sibylle Madlener, Dominik Kirchhofer, Ilon Liu, Jason Pyrdol, Volker Hovestadt, Emanuele Mazzola, Nathan D. Mathewson, Maria Trissal, Daniela Lötsch, Christian Dorfer, Christine Haberler, Angela Halfmann, Lisa Mayr, Andreas Peyrl, Rene Geyeregger, Benjamin Schwalm, Monica Mauermann, Kristian W. Pajtler
Opublikowane w: Cancer Cell, Numer 38/1, 2020, Strona(/y) 44-59.e9, ISSN 1535-6108
Wydawca: Cell Press
DOI: 10.1016/j.ccell.2020.06.004

Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours

Autorzy: Nil A. Schubert, Celine Y. Chen, Ana Rodríguez, Jan Koster, Michele Dowless, Stefan M. Pfister, David J. Shields, Louis F. Stancato, Gilles Vassal, Hubert N. Caron, Marlinde L. van den Boogaard, Anton G. Henssen, Jan J. Molenaar
Opublikowane w: European Journal of Cancer, Numer 170 (2022), 2022, Strona(/y) 196 – 208, ISSN 0959-8049
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2022.04.028

Book chapters (1)

Ewing Sarcoma PDX Models

Autorzy: Didier Surdez, Lorena Landuzzi, Katia Scotlandi, Maria Cristina Manara
Opublikowane w: Ewing Sarcoma - Methods and Protocols, Numer 2226, 2021, Strona(/y) 223-242, ISBN 978-1-0716-1019-0
Wydawca: Springer US
DOI: 10.1007/978-1-0716-1020-6_18

Thesis and dissertations (1)

Molecular and preclinical evaluation of patient-derived orthotopic xenograft models of pediatric brain tumors

Autorzy: Sebastian Brabetz
Opublikowane w: 2018
Wydawca: Univesity of Heidelberg