ITCC Pediatric Preclinical POC Platform – Sofia ref.: 116064

Información del proyecto

ITCC-P4

Identificador del acuerdo de subvención: 116064

DOI

10.3030/116064

Proyecto cerrado

Fecha de la firma de la CE 18 Mayo 2017

Fecha de inicio 1 Enero 2017

Fecha de finalización 31 Diciembre 2023

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 19 930 472,94

Aportación de la UE

€ 7 370 000,00

Coordinado por

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (3)

Final draft and Submission of a paper for publication

Migration

Launch of the sustainability platform

Migration

International scientific symposium on : “Preclinicalevaluation in pediatric oncology drug development”

Migration

Publicaciones

Peer reviewed articles (18)

Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity

Autores: Gabriele Manzella, Leonie D. Schreck, Willemijn B. Breunis, Jan Molenaar, Hans Merks, Frederic G. Barr, Wenyue Sun, Michaela Römmele, Luduo Zhang, Joelle Tchinda, Quy A. Ngo, Peter Bode, Olivier Delattre, Didier Surdez, Bharat Rekhi, Felix K. Niggli, Beat W. Schäfer, Marco Wachtel
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-18388-7

Targeting fibroblast growth factor receptors to combat aggressive ependymoma

Autores: Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, Laemmerer A, Gabler L, Pirker C, Donson AM, Bannauer P, Korbel P, Jaunecker CN, Hübner JM, Mayr L, Madlener S, Schmook MT, Ricken G, Maaß K, Grusch M, Holzmann K, Grasl-Kraupp B, Spiegl-Kreinecker S, Hsu J, Dorfer C, Rössler K, Azizi AA, Foreman NK, Peyrl A, Haberler C, Czech T, Slavc I, Filbin MG, Pajtler KW, Kool M, Ber
Publicado en: Acta neuropathologica communications, Edición 2021 Aug; 142(2), 2021, Página(s) 339-360, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-021-02327-x

Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers

Autores: Nil A. Schubert, Caitlin D. Lowery, Guillaume Bergthold, Jan Koster, Thomas F. Eleveld, Ana Rodríguez, David T.W. Jones, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Hubert N. Caron, Jan J. Molenaar
Publicado en: European Journal of Cancer, Edición 130, 2020, Página(s) 168-181, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2020.01.027

Crossing Oceans: Preclinical Collaboration to Improve Pediatric Drug Development

Autores: Gregory Reaman, Louis Stancato, Gilles Vassal, John M. Maris
Publicado en: American Society of Clinical Oncology Educational Book, Edición 40, 2020, Página(s) 409-416, ISSN 1548-8748
Editor: American Society of Clinical Oncology
DOI: 10.1200/edbk_278893

International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer

Autores: Vassal, G. Houghton, P. J. Pfister, S. M. Smith, M. A. Caron, H. N. Li, X. N. Shields, D. J. Witt, O. Molenaar, J. J. Colombetti, S. Schuler, J. Stancato, L. F.
Publicado en: Mol Cancer Ther, Edición Volume 20, 2021, Página(s) 1462–8, ISSN 1535-7163
Editor: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-20-0394

Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas

Autores: Helena Castillo-Ecija, Guillem Pascual-Pasto, Sara Perez-Jaume, Claudia Resa-Pares, Monica Vila-Ubach, Carles Monterrubio, Ana Jimenez-Cabaco, Merce Baulenas-Farres, Oscar Muñoz-Aznar, Noelia Salvador, Maria Cuadrado-Vilanova, Nagore G. Olaciregui, Leire Balaguer-Lluna, Victor Burgueño, Francisco J. Vicario, Alejandro Manzanares, Alicia Castañeda, Vicente Santa-Maria, Ofelia Cruz, Veronica Celi
Publicado en: Journal of Pathology – clinical research, Edición Volume 7, Issu 4, July 2021, 2021, Página(s) 338-349, ISSN 2056-4538
Editor: Wiley
DOI: 10.1002/cjp2.210

Integrated molecular characterization of patient-derived models reveals therapeutic strategies for treating CIC-DUX4 sarcoma

Autores: Carrabotta M, Laginestra MA, Durante G, Mancarella C, Landuzzi L, Parra A, Ruzzi F, Toracchio L, De Feo A, Giusti V, Pasello M, Righi A, Lollini PL, Palmerini E, Donatii DM, Manara MC, Scotlandi K.
Publicado en: Cancer Research, Edición 2022 Feb 15;82(4), 2021, Página(s) 708-720, ISSN 1538-7445
Editor: AACR
DOI: 10.1158/0008-5472.can-21-1222

Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput <i>in vivo</i> testing

Autores: Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Ol
Publicado en: Cancer Research, Edición 83, 2023, Página(s) 234-234, ISSN 1538-7445
Editor: AACR
DOI: 10.1158/1538-7445.am2023-234

Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for pediatric solid malignancies

Autores: Kaylee M. Keller; Apurva Gopisetty; Dan Luedtke; Jan Koster; Nil A. Schubert; Ana Rodríguez; Sander R. van Hooff; Damian Stichel; Emmy M. Dolman; Gilles Vassal; Stefan M. Pfister; Hubert N. Caron; Louis F. Stancato; Jan J. Molenaar; Natalie Jäger; Marcel Kool
Publicado en: Eur J Cancer, Edición Dec 25, 2021; Volume 162, February 2022, 2021, Página(s) Pages 107-117, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2021.11.030

Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models

Autores: Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir, Alexandra Saint-Charles, Justyna Wierzbinska, Andreas Schlicker, Richard Volckmann, Danny Zwijnenburg, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Christina Guttke, Maureen M. Hattersley, Frédéric Colland, Ashley Strougo, María José Guillén, Louis
Publicado en: Cancer Research, Edición 83, 2023, Página(s) 3571-3571, ISSN 1538-7445
Editor: AACR
DOI: 10.1158/1538-7445.am2023-3571

A biobank of patient-derived pediatric brain tumor models

Autores: Sebastian Brabetz, Sarah E. S. Leary, Susanne N. Gröbner, Madison W. Nakamoto, Huriye Şeker-Cin, Emily J. Girard, Bonnie Cole, Andrew D. Strand, Karina L. Bloom, Volker Hovestadt, Norman L. Mack, Fiona Pakiam, Benjamin Schwalm, Andrey Korshunov, Gnana Prakash Balasubramanian, Paul A. Northcott, Kyle D. Pedro, Joyoti Dey, Stacey Hansen, Sally Ditzler, Peter Lichter, Lukas Chavez, David T. W. Jone
Publicado en: Nature Medicine, Edición 24/11, 2018, Página(s) 1752-1761, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-018-0207-3

PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH

Autores: Sebastian Brabetz, Susanne N Groebner, Natalie Jaeger, Till Milde, Jonas Ecker, Florian Selt, Olaf Witt, Jessica M Rusert, Jan Koster, Sarah E Leary, Xiao-Nan Li, Robert J Wechsler-Reya, James M Olson, Stefan M Pfister, Marcel Kool
Publicado en: Neuro-Oncology, Edición 20/suppl_2, 2018, Página(s) i155-i155, ISSN 1522-8517
Editor: Duke University Press
DOI: 10.1093/neuonc/noy059.574

Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors

Autores: Natalie Timme, Youjia Han, Shuai Liu, Hailemichael O. Yosief, Heathcliff Dorado García, Yi Bei, Filippos Klironomos, Ian C. MacArthur, Annabell Szymansky, Jennifer von Stebut, Victor Bardinet, Constantin Dohna, Annette Künkele, Jana Rolff, Patrick Hundsdörfer, Andrej Lissat, Georg Seifert, Angelika Eggert, Johannes H. Schulte, Wei Zhang, Anton G. Henssen
Publicado en: Translational Oncology, Edición 13/2, 2020, Página(s) 221-232, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1016/j.tranon.2019.09.013

ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Autores: Cinzia Zucchini, Maria Cristina Manara, Camilla Cristalli, Marianna Carrabotta, Sara Greco, Rosa Simona Pinca, Cristina Ferrari, Lorena Landuzzi, Michela Pasello, Pier-Luigi Lollini, Marco Gambarotti, Davide Maria Donati, Katia Scotlandi
Publicado en: Journal of Experimental & Clinical Cancer Research, Edición 38/1, 2019, ISSN 1756-9966
Editor: J Exp Clin Cancer Res
DOI: 10.1186/s13046-019-1506-3

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma

Autores: Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger
Publicado en: Acta Neuropathologica Communications, Edición 7/1, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-019-0775-6

Abstract 3524: Pharmacological characterization of pediatric brain tumor PDX models in a single mouse trial format

Autores: Eva Oswald, Dorothee Lenhard, Kanstantsin Lashuk, Stefan Pfister, Louis Stancato, Julia Schueler
Publicado en: Cancer Research, Edición 83, 2023, Página(s) 3524-3524, ISSN 1538-7445
Editor: AACR
DOI: 10.1158/1538-7445.am2023-3524

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Autores: Johannes Gojo, Bernhard Englinger, Li Jiang, Jens M. Hübner, McKenzie L. Shaw, Olivia A. Hack, Sibylle Madlener, Dominik Kirchhofer, Ilon Liu, Jason Pyrdol, Volker Hovestadt, Emanuele Mazzola, Nathan D. Mathewson, Maria Trissal, Daniela Lötsch, Christian Dorfer, Christine Haberler, Angela Halfmann, Lisa Mayr, Andreas Peyrl, Rene Geyeregger, Benjamin Schwalm, Monica Mauermann, Kristian W. Pajtler
Publicado en: Cancer Cell, Edición 38/1, 2020, Página(s) 44-59.e9, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2020.06.004

Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours

Autores: Nil A. Schubert, Celine Y. Chen, Ana Rodríguez, Jan Koster, Michele Dowless, Stefan M. Pfister, David J. Shields, Louis F. Stancato, Gilles Vassal, Hubert N. Caron, Marlinde L. van den Boogaard, Anton G. Henssen, Jan J. Molenaar
Publicado en: European Journal of Cancer, Edición 170 (2022), 2022, Página(s) 196 – 208, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2022.04.028

Book chapters (1)

Ewing Sarcoma PDX Models

Autores: Didier Surdez, Lorena Landuzzi, Katia Scotlandi, Maria Cristina Manara
Publicado en: Ewing Sarcoma - Methods and Protocols, Edición 2226, 2021, Página(s) 223-242, ISBN 978-1-0716-1019-0
Editor: Springer US
DOI: 10.1007/978-1-0716-1020-6_18

Thesis and dissertations (1)

Molecular and preclinical evaluation of patient-derived orthotopic xenograft models of pediatric brain tumors

Autores: Sebastian Brabetz
Publicado en: 2018
Editor: Univesity of Heidelberg