SYSTEMS ANALYSIS OF ADULT AND PEDIATRIC RESPONSES TO THE VSV-ZEBOV EBOLA VACCINE - Sofia ref.: 116068 | VSV-EBOPLUS | Project | Results | H2020 | CORDIS

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Distribution of month 36 samples from phase I/II clinical trials in Switzerland and Gabon

Migration

Distribution of month 24 samples from phase I/II clinical trials in Switzerland and Gabon

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Distribution of month 48 samples from phase I/II clinical trials in Switzerland and Gabon

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Distribution of samples (serum, plasma, Paxgene tubes) to partners involved in immunogenicity / transcriptomic studies

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Distribution of month 60 samples from phase I/II clinical trials in Switzerland and Gabon

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Distribution of serum, plasma and RNA samples in pediatric trial in Lambaréné

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Veröffentlichungen

Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

Autoren: Vianello E., Gonzalez-Dias P, van Veen S, Engele CG, Quinten E, Monath TP, Medaglini D, VSV-EBOVAC and VSV-EBOPLUS Consortia, Santoro F, Huttner A, Dubey S, Eichberg M, Ndungu FM, Kremsner PG, Essone PN, Agnandji ST, Siegrist CA, Nakaya HI, Ottenhoff THM, and Haks MC
Veröffentlicht in: The Lancet Microbe, 2021, ISSN 1473-3099
Herausgeber: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00235-4

Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability

Autoren: Angela Huttner, Selidji Todagbe Agnandji, Olivier Engler, Jay W. Hooper, Steve Kwilas, Keersten Ricks, Tamara L. Clements, Hulda R. Jonsdottir, Sravya Sowdamini Nakka, Sylvia Rothenberger, Peter Kremsner, Roland Züst, Donata Medaglini, Tom Ottenhoff, Ali M. Harandi, Claire-Anne Siegrist on behalf of the VEBCON, VSV-EBOVAC , VSV-EBOPLUS Consortia
Veröffentlicht in: Clin Microbiol Infect, 2023, ISSN 1469-0691
Herausgeber: Elsevier
DOI: 10.1016/j.cmi.2023.08.026

Global blood miRNA profiling unravels early miRNA signatures of the immunogenicity of licensed Ebola vaccine rVSVΔG-ZEBOV-GP in humans

Autoren: Eleonora Vianello, Josefine Persson, Björn Andersson, Suzanne van Veen, Thomaz Lüscher Dias, Francesco Santoro, Malin Östensson, Ogonna Obudulu, Christopher Agbajogu, Sara Torkzadeh, Helder Nakaya, Donata Medaglini, Claire-Anne Siegrist, Tom H. M. Ottenhoff MD, and Ali M. Harandi. On behalf of the VEBCON, VSV-EBOVAC, and VSV-EBOPLUS Consortia
Veröffentlicht in: iScience, 2023, ISSN 2589-0042
Herausgeber: Cell Press
DOI: 10.1016/j.isci.2023.108574

Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine

Autoren: Francesco Santoro, Alessia Donato, Simone Lucchesi, Sara Sorgi, Alice Gerlini, Marielle Haks, Tom Ottenhoff, Patricia Gonzalez-Dias, VSV-EBOVAC Consortium, VSV-EBOPLUS Consortium, Helder Nakaya, Angela Huttner, Claire-Anne Siegrist, Donata Medaglini, Gianni Pozzi
Veröffentlicht in: Vaccines, Ausgabe 9/2, 2021, Seite(n) 67, ISSN 2076-393X
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9020067

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study

Autoren: Angela Huttner, Selidji Todagbe Agnandji, Christophe Combescure, José F Fernandes, Emmanuel Bache Bache, Lumeka Kabwende, Francis Maina Ndungu, Jessica Brosnahan, Thomas P Monath, Barbara Lemaître, Stéphane Grillet, Miriam Botto, Olivier Engler, Jasmine Portmann, Denise Siegrist, Philip Bejon, Peter Silvera, Peter Kremsner, Claire-Anne Siegrist, Sanjeev KRISHNA, Marylyn M. ADDO, Stephan BECKER,
Veröffentlicht in: The Lancet Infectious Diseases, Ausgabe 18/7, 2018, Seite(n) 738-748, ISSN 1473-3099
Herausgeber: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(18)30165-8

Correlates of vaccine-induced protective immunity against Ebola virus disease

Autoren: Donata Medaglini, Francesco Santoro, Claire-Anne Siegrist
Veröffentlicht in: Seminars in Immunology, 2018, ISSN 1044-5323
Herausgeber: Academic Press
DOI: 10.1016/j.smim.2018.07.003

Durability of single-dose rVSV-ZEBOV vaccine responses: what do we know?

Autoren: Angela Huttner, Claire-Anne Siegrist
Veröffentlicht in: Expert Review of Vaccines, Ausgabe 17/12, 2018, Seite(n) 1105-1110, ISSN 1476-0584
Herausgeber: Future Drugs Ltd.
DOI: 10.1080/14760584.2018.1546582

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

Autoren: David Pejoski, Casimir de Rham, Paola Martinez-Murillo, Francesco Santoro, Floriane Auderset, Donata Medaglini, Gianni Pozzi, Maria Vono, Paul-Henri Lambert, Angela Huttner, Mariëlle C. Haks, Tom H. M. Ottenhoff, Jean Villard, Claire-Anne Siegrist
Veröffentlicht in: npj Vaccines, Ausgabe 5/1, 2020, ISSN 2059-0105
Herausgeber: Springer Nature
DOI: 10.1038/s41541-020-0179-4

Safety, immunogenicity and risk–benefit analysis of rVSV-ΔG-ZEBOV-GP (V920) Ebola vaccine in Phase I–III clinical trials across regions

Autoren: Bache Emmanuel Bache, Martin P Grobusch, Selidji Todagbe Agnandji
Veröffentlicht in: Future Microbiology, Ausgabe 15/2, 2020, Seite(n) 85-106, ISSN 1746-0913
Herausgeber: Future Medicine Ltd.
DOI: 10.2217/fmb-2019-0237

Methods for predicting vaccine immunogenicity and reactogenicity

Autoren: Patrícia Gonzalez-Dias, Eva K. Lee, Sara Sorgi, Diógenes S. de Lima, Alysson H. Urbanski, Eduardo Lv Silveira, Helder I. Nakaya
Veröffentlicht in: Human Vaccines & Immunotherapeutics, Ausgabe 16/2, 2020, Seite(n) 269-276, ISSN 2164-5515
Herausgeber: Landes Bioscience
DOI: 10.1080/21645515.2019.1697110

SYSTEMS ANALYSIS OF ADULT AND PEDIATRIC RESPONSES TO THE VSV-ZEBOV EBOLA VACCINE - Sofia ref.: 116068

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