SYSTEMS ANALYSIS OF ADULT AND PEDIATRIC RESPONSES TO THE VSV-ZEBOV EBOLA VACCINE - Sofia ref.: 116068 | VSV-EBOPLUS | Project | Results | H2020 | CORDIS

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Distribution of month 36 samples from phase I/II clinical trials in Switzerland and Gabon

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Distribution of month 24 samples from phase I/II clinical trials in Switzerland and Gabon

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Distribution of month 48 samples from phase I/II clinical trials in Switzerland and Gabon

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Distribution of samples (serum, plasma, Paxgene tubes) to partners involved in immunogenicity / transcriptomic studies

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Distribution of month 60 samples from phase I/II clinical trials in Switzerland and Gabon

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Distribution of serum, plasma and RNA samples in pediatric trial in Lambaréné

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Pubblicazioni

Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

Autori: Vianello E., Gonzalez-Dias P, van Veen S, Engele CG, Quinten E, Monath TP, Medaglini D, VSV-EBOVAC and VSV-EBOPLUS Consortia, Santoro F, Huttner A, Dubey S, Eichberg M, Ndungu FM, Kremsner PG, Essone PN, Agnandji ST, Siegrist CA, Nakaya HI, Ottenhoff THM, and Haks MC
Pubblicato in: The Lancet Microbe, 2021, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00235-4

Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability

Autori: Angela Huttner, Selidji Todagbe Agnandji, Olivier Engler, Jay W. Hooper, Steve Kwilas, Keersten Ricks, Tamara L. Clements, Hulda R. Jonsdottir, Sravya Sowdamini Nakka, Sylvia Rothenberger, Peter Kremsner, Roland Züst, Donata Medaglini, Tom Ottenhoff, Ali M. Harandi, Claire-Anne Siegrist on behalf of the VEBCON, VSV-EBOVAC , VSV-EBOPLUS Consortia
Pubblicato in: Clin Microbiol Infect, 2023, ISSN 1469-0691
Editore: Elsevier
DOI: 10.1016/j.cmi.2023.08.026

Global blood miRNA profiling unravels early miRNA signatures of the immunogenicity of licensed Ebola vaccine rVSVΔG-ZEBOV-GP in humans

Autori: Eleonora Vianello, Josefine Persson, Björn Andersson, Suzanne van Veen, Thomaz Lüscher Dias, Francesco Santoro, Malin Östensson, Ogonna Obudulu, Christopher Agbajogu, Sara Torkzadeh, Helder Nakaya, Donata Medaglini, Claire-Anne Siegrist, Tom H. M. Ottenhoff MD, and Ali M. Harandi. On behalf of the VEBCON, VSV-EBOVAC, and VSV-EBOPLUS Consortia
Pubblicato in: iScience, 2023, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2023.108574

Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine

Autori: Francesco Santoro, Alessia Donato, Simone Lucchesi, Sara Sorgi, Alice Gerlini, Marielle Haks, Tom Ottenhoff, Patricia Gonzalez-Dias, VSV-EBOVAC Consortium, VSV-EBOPLUS Consortium, Helder Nakaya, Angela Huttner, Claire-Anne Siegrist, Donata Medaglini, Gianni Pozzi
Pubblicato in: Vaccines, Numero 9/2, 2021, Pagina/e 67, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9020067

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study

Autori: Angela Huttner, Selidji Todagbe Agnandji, Christophe Combescure, José F Fernandes, Emmanuel Bache Bache, Lumeka Kabwende, Francis Maina Ndungu, Jessica Brosnahan, Thomas P Monath, Barbara Lemaître, Stéphane Grillet, Miriam Botto, Olivier Engler, Jasmine Portmann, Denise Siegrist, Philip Bejon, Peter Silvera, Peter Kremsner, Claire-Anne Siegrist, Sanjeev KRISHNA, Marylyn M. ADDO, Stephan BECKER,
Pubblicato in: The Lancet Infectious Diseases, Numero 18/7, 2018, Pagina/e 738-748, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(18)30165-8

Correlates of vaccine-induced protective immunity against Ebola virus disease

Autori: Donata Medaglini, Francesco Santoro, Claire-Anne Siegrist
Pubblicato in: Seminars in Immunology, 2018, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/j.smim.2018.07.003

Durability of single-dose rVSV-ZEBOV vaccine responses: what do we know?

Autori: Angela Huttner, Claire-Anne Siegrist
Pubblicato in: Expert Review of Vaccines, Numero 17/12, 2018, Pagina/e 1105-1110, ISSN 1476-0584
Editore: Future Drugs Ltd.
DOI: 10.1080/14760584.2018.1546582

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

Autori: David Pejoski, Casimir de Rham, Paola Martinez-Murillo, Francesco Santoro, Floriane Auderset, Donata Medaglini, Gianni Pozzi, Maria Vono, Paul-Henri Lambert, Angela Huttner, Mariëlle C. Haks, Tom H. M. Ottenhoff, Jean Villard, Claire-Anne Siegrist
Pubblicato in: npj Vaccines, Numero 5/1, 2020, ISSN 2059-0105
Editore: Springer Nature
DOI: 10.1038/s41541-020-0179-4

Safety, immunogenicity and risk–benefit analysis of rVSV-ΔG-ZEBOV-GP (V920) Ebola vaccine in Phase I–III clinical trials across regions

Autori: Bache Emmanuel Bache, Martin P Grobusch, Selidji Todagbe Agnandji
Pubblicato in: Future Microbiology, Numero 15/2, 2020, Pagina/e 85-106, ISSN 1746-0913
Editore: Future Medicine Ltd.
DOI: 10.2217/fmb-2019-0237

Methods for predicting vaccine immunogenicity and reactogenicity

Autori: Patrícia Gonzalez-Dias, Eva K. Lee, Sara Sorgi, Diógenes S. de Lima, Alysson H. Urbanski, Eduardo Lv Silveira, Helder I. Nakaya
Pubblicato in: Human Vaccines & Immunotherapeutics, Numero 16/2, 2020, Pagina/e 269-276, ISSN 2164-5515
Editore: Landes Bioscience
DOI: 10.1080/21645515.2019.1697110

SYSTEMS ANALYSIS OF ADULT AND PEDIATRIC RESPONSES TO THE VSV-ZEBOV EBOLA VACCINE - Sofia ref.: 116068

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