Obiettivo Malaria is one of the three major infectious diseases. Although the disease is prevalent in the tropics and subtropics it has caused a global emergency. 300-400 million cases with 1-2 million deaths per year and rapidly increasing resistance to antimalarial drugs call for focused novel strategies on combating malaria. Transport proteins for nutrients and metabolites of the minimal parasite/host interface are getting into the focus of the current search for novel antimalarial targets. MalariaPorin is an interdisciplinary project that wants to take genomic information to drug development. The chief goal is to decide on the question whether the Plasmodium water and glycerol channel, aquaglyceroporin, of the parasite/host interface is a suitable drug target for chemotherapy. Concurrently, the conditions for generating aquaglyceroporin inhibitory drugs are developed. To achieve these goals, a multidisciplinary approach is taken covering a) thorough studies on the physiological role of water and glycerol transport in the malaria parasite including the generation of deletion strains; b) establishment of robust and practical assay systems for compound testing based on Xenopus laevis oocytes, yeast and P. falciparum parasites; c) determination from field isolates of the occurrence and functional consequences of polymorphisms of the aquaglyceroporin gene; d) generation of protein structure models and elucidation of the 3D structure from protein crystallisation for solving mechanistic questions on the channel selectivity and for virtual drug design; e) design and synthesis of compound libraries based on the knowledge of other aquaporin blockers and biochemical studies of substrate specificity. It is envisioned that MalariaPorin may become the starting point for a wider strategy to assess the role of aquaporins in pathogenic parasites, such as Toxoplasma gondii and Trypanosoma brucei and cruzi, and their potential use as drug targets. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LIFESCIHEALTH-2.3.0 - Developing new promising candidate vaccines and therapies Invito a presentare proposte FP6-2003-LIFESCIHEALTH-3 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIEL Contributo UE Nessun dato Indirizzo Olshausenstr. 40 KIEL Germania Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto GOTEBORG UNIVERSITY Svezia Contributo UE Nessun dato Indirizzo Vasaparken 100 GOTEBORG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF EDINBURGH Regno Unito Contributo UE Nessun dato Indirizzo Old College, South Bridge EDINBURGH Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germania Contributo UE Nessun dato Indirizzo Hofgartenstrasse 8 MUENCHEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE Stati Uniti Contributo UE Nessun dato Indirizzo 725 N. Wolfe Street BALTIMORE, MD Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF MANCHESTER Regno Unito Contributo UE Nessun dato Indirizzo Oxford Road MANCHESTER Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato EBERHHARD-KARLS-UNIVERSITÄT TÜBINGEN Germania Contributo UE Nessun dato Indirizzo Wilhelmstr. 5 TUEBINGEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato