Cel Malaria is one of the three major infectious diseases. Although the disease is prevalent in the tropics and subtropics it has caused a global emergency. 300-400 million cases with 1-2 million deaths per year and rapidly increasing resistance to antimalarial drugs call for focused novel strategies on combating malaria. Transport proteins for nutrients and metabolites of the minimal parasite/host interface are getting into the focus of the current search for novel antimalarial targets. MalariaPorin is an interdisciplinary project that wants to take genomic information to drug development. The chief goal is to decide on the question whether the Plasmodium water and glycerol channel, aquaglyceroporin, of the parasite/host interface is a suitable drug target for chemotherapy. Concurrently, the conditions for generating aquaglyceroporin inhibitory drugs are developed. To achieve these goals, a multidisciplinary approach is taken covering a) thorough studies on the physiological role of water and glycerol transport in the malaria parasite including the generation of deletion strains; b) establishment of robust and practical assay systems for compound testing based on Xenopus laevis oocytes, yeast and P. falciparum parasites; c) determination from field isolates of the occurrence and functional consequences of polymorphisms of the aquaglyceroporin gene; d) generation of protein structure models and elucidation of the 3D structure from protein crystallisation for solving mechanistic questions on the channel selectivity and for virtual drug design; e) design and synthesis of compound libraries based on the knowledge of other aquaporin blockers and biochemical studies of substrate specificity. It is envisioned that MalariaPorin may become the starting point for a wider strategy to assess the role of aquaporins in pathogenic parasites, such as Toxoplasma gondii and Trypanosoma brucei and cruzi, and their potential use as drug targets. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LIFESCIHEALTH-2.3.0 - Developing new promising candidate vaccines and therapies Zaproszenie do składania wniosków FP6-2003-LIFESCIHEALTH-3 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIEL Wkład UE Brak danych Adres Olshausenstr. 40 KIEL Niemcy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko GOTEBORG UNIVERSITY Szwecja Wkład UE Brak danych Adres Vasaparken 100 GOTEBORG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE UNIVERSITY OF EDINBURGH Zjednoczone Królestwo Wkład UE Brak danych Adres Old College, South Bridge EDINBURGH Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Niemcy Wkład UE Brak danych Adres Hofgartenstrasse 8 MUENCHEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE Stany Zjednoczone Wkład UE Brak danych Adres 725 N. Wolfe Street BALTIMORE, MD Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE UNIVERSITY OF MANCHESTER Zjednoczone Królestwo Wkład UE Brak danych Adres Oxford Road MANCHESTER Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych EBERHHARD-KARLS-UNIVERSITÄT TÜBINGEN Niemcy Wkład UE Brak danych Adres Wilhelmstr. 5 TUEBINGEN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
