Project description
A boost for EV manufacturing for tissue regeneration
Extracellular vesicles (EVs) are being explored as drug delivery vehicles. They are stable in circulation and contain microRNAs (miRNAs) which are important in physiologic and pathologic regulation. EVs are as effective as cell therapies for tissue regeneration for diseases such as stroke, heart failure and arthritis. However, the ability to produce quantities compatible with human use is a challenge. The French EVerZom company has developed a patented, fast, cost-effective, large-scale standardised extracellular vesicles (EV) production process to address the manufacturing issues that hamper EV translation towards clinic. The EU-funded ACROBAT project will assist EverZom to validate the platform and scale up towards commercial batch production.
Objective
EVerZom has developed a patented, fast, cost-effective, large-scale standardized extracellular vesicles (EV) production process to address the manufacturing issues that hamper EV translation towards clinic. EVerZom has performed a successful platform scale-up to 6L, meeting quantities needed for phase I trials, placing it at least 2 years ahead of known competitors.
With numerous European biotechs poised to enter clinical phase, its timely to provide industrial players with EV large-scale capabilities. Hence, EVerZom intends to achieve key milestones during the next 2 years including the validation of platform GMP compliance at clinical phase I scale, the scale-up toward late-stage and commercial batch production as well as platform expansion usefulness towards different cell lines.
The ACROBAT project will enable us to be aligned with industrial players roadmap, generate early revenues, and achieve our ambition to be a European pioneer and leader in the EV manufacturing market.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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HORIZON.3.1.2 - The Accelerator
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended Finance
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2021-ACCELERATORCHALLENGES-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75014 Paris
France
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.