Obiettivo
Specific Objectives
- Development, validation and testing of optical-fibre sensors for in-vivo diagnostics/monitoring;
- Development of fluorescence based medical diagnostic techniques;
- Validation of photon-tissue interaction model for bio-medical imaging;
- Development of production technologies for not commercially available medical radioisotopes (e.g. commercial distribution of FDG);
- FE model validation of bony material, for improved osteoporosis diagnosis;
- Finite element modelling of prosthetic devices, for pre-clinical assessment;
- Setting up of appropriate networks.
Planned Deliverables
Specific deliverables to DGs:
- Assessments on an ad-hoc basis on specific subjects related to the project;
- Knowledge base for guidelines on implementation of minimally invasive medical systems;
- Watch/Alert function for advanced minimally-invasive medical technologies.
As a result of the research:
- Reports, conference and journal publications;
- Patents;
- European networks;
- Workshops;
- Testing techniques and facilities.
Summary of deliverables made by: 31/12/2001
Set-up of optical system for writing Bragg-gratings for fibre optic sensors
Set-up of experimental system for fluorescence-lifetime imaging studies;
Testing of Monte-Carlo computer code for the analysis of photon migration in tissue;
Setting up of MEDPHOT network website, database design, initial data input;
New thematic network (European Virtual Institute for Geometry Measurements, EVIGeM);
Initiation of studies on optical and X-ray photogrammetry applications.
Set-up of the FDG production laboratory completed.
Study of new production routes for 64Cu.
Reviews of bone analysis techniques in relation to osteoporosis;
FE studies of the human femur and its mechanical reaction to loading.
Output Indicators and Impact
DG contacts (meetings, reports, joint actions)
Collaboration contracts, networks, SCAs;
Publications, technical notes, patents reviews;
Technical achievements (clinical trials, isotope production);
Students, scientific visitors, invited seminars.
Summary of the project
This project focuses on the investigation and development of minimally-invasive medical techniques for medical diagnosis and therapy with emphasis on three main themes: optical methods, nuclear medicine, and bio-mechanical modelling.
A wide variety of non-invasive or minimally invasive optical diagnostic methods exists, offering many potential applications in medicine. Priority is given to research on optical fibre sensors for in-vivo diagnostics/monitoring, optical fluorescence techniques for imaging/diagnosis, modelling of photon tissue interaction for medical imaging, and full-field optical techniques for mechanical characterisation of synthetic and natural biomaterials. The BMS Unit is now managing a network (MEDPHOT) that aims to develop and assess a variety of optical methods in medical diagnostics, as well as to address the problem of standardisation in this field.
Radioisotope use in medical diagnosis and therapy is well established, and new and improved techniques are under continuous development. The cyclotron facility of the BMS Unit of IHCP has been producing medical radioisotopes for some years now, driven by a strong customer demand. Research will be performed on the production technologies for radioisotopes for new diagnosis and therapeutic methods. In particular appropriate target and isotope extraction facilities will be developed for isotopes requested by clinical partners. A related network on Health Technology Assessment of Positron Emission.
Tomography in Oncology will be proposed.
Osteoporosis is becoming a greater and greater problem, primarily for the individual, but also in terms of cost to society. There is a great need for non-invasive diagnostic screening techniques, as well as improved knowledge of the relationship between bone biochemistry/architecture and mechanical properties. The project will perform finite element modelling studies of bone-like materials, and of prosthetic devices in order to contribute to the validation of new diagnostic techniques and to increase knowledge of bone biomechanics. Validation of the finite element models will be possible using full-field optical techniques on appropriate samples.
Rationale
The demography of the European population is rapidly changing, with the average age continuously increasing. This will contribute inevitably to rising incidences of many diseases and of various medical conditions requiring intervention. In some cases early diagnosis is critical for survival - the obvious example being cancer. In other cases there is a great need for screening techniques that can warn of potential problems in order for appropriate prevention steps to be undertaken. Osteoporosis is a good example of a condition that urgently requires a reliable and non-invasive diagnostic/screening method. In general the less invasive a diagnostic/screening or therapeutic method is the more advantageous it is in terms of patient comfort, speed of recovery, and cost. The aim of this project is to investigate, develop and validate new minimally invasive techniques for diagnosis and therapy of various diseases, with a view to supporting European policy development, and norms and standards in this politically important area. It is of importance that the JRC monitors new developments in this field, via appropriate networking opportunities, in order to be in an appropriate position to perform such a function. The efforts in the project will effectively utilise the available expertise and experience of the Unit, which now includes an internationally recognised research group active in the field of optical technologies in medicine.
Campo scientifico (EuroSciVoc)
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: Il Vocabolario Scientifico Europeo.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: Il Vocabolario Scientifico Europeo.
- scienze naturali scienze fisiche fisica teoretica fisica delle particelle acceleratore di particelle
- scienze naturali scienze biologiche biofisica
- scienze naturali matematica matematica pura geometria
- scienze naturali scienze fisiche ottica fibra ottica
- scienze naturali scienze fisiche fisica teoretica fisica delle particelle fotoni
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Programma(i)
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Programmi di finanziamento pluriennali che definiscono le priorità dell’UE in materia di ricerca e innovazione.
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Gli inviti a presentare proposte sono suddivisi per argomenti. Un argomento definisce un’area o un tema specifico per il quale i candidati possono presentare proposte. La descrizione di un argomento comprende il suo ambito specifico e l’impatto previsto del progetto finanziato.
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Meccanismo di finanziamento
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Meccanismo di finanziamento (o «Tipo di azione») all’interno di un programma con caratteristiche comuni. Specifica: l’ambito di ciò che viene finanziato; il tasso di rimborso; i criteri di valutazione specifici per qualificarsi per il finanziamento; l’uso di forme semplificate di costi come gli importi forfettari.
Coordinatore
Ispra
Italia
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