Final Report Summary - INFRAFRONTIER (Infrafrontier The European infrastructure for phenotyping and archiving of model mammalian genomes)
Systemic Phenotyping
Systemic phenotyping is the comprehensive functional and molecular characterisation of mouse lines in all relevant organ systems and disease areas. The mouse clinics partnering in INFRAFRONTIER use cutting-edge technologies, among them the latest in vivo imaging techniques and non-invasive methods, to reveal the role of the genes and environment on development, morphology, physiology, metabolism, behaviour and pathology. The efficient use of modern analytic technology and data management tools provides novel insights into gene function and creates basis for new therapeutic approaches and disease prevention strategies.
Archiving and Distribution
Keeping live mice on shelf for extended periods is not only costly, it also bears the risk of losing biologically relevant phenotypes due to genetic drift or disease, and it is not desirable for animal welfare reasons. Mouse repositories therefore preserve scientifically valuable mouse models and distribute them to upon request to the biomedical research community.
EMMA - The European Mouse Mutant Archive is the leading mouse repository in Europe and important partner in the global network of mouse archives. EMMA offers archiving and distribution of mouse models under highest quality standards and access to the strain data in the EMMA resource database. An additional specialized service of EMMA is the generation of germ-free (axenic) mice.
List of Websites:
www.infrafrontier.eu