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Biomarkers for post market monitoring of short and long-term effects of genetically modified organisms (GMOs) on animal and human health

Objective

The function of post market monitoring is to further assess possible nutritional and health effects of authorized GM foods on a mixed population of human and animal consumers. Currently, however, little is known about exposure levels, whether adverse effects are predictable, and the occurrence of any unexpected effects following market release of GM foods. Our objective is to identify a panel of anatomic, physiologic, biochemical, molecular, allergenic, and immunogenic biomarkers, which could be used to predict harmful GMO effects after product authorization. Using a prototype allergenic α-amylase inhibitor GM-pea, we will extrapolate multiple biomarker databases that correlate GMO effects during gestation, growth, maturation in various animal models with humans. We will establish biomarkers in GMO-fed pigs, salmon, rats, and mice, in addition to indirect effects of GM feeding in the food chain and GMO influence during an underlying allergic disorder. These experiments will yield data on general health with a specific focus on allergy and immunology. To extrapolate our data to humans, we will establish a comparative database with antigenic epitopes and antibody crossreactivity in legume allergic patients and human-mouse chimera in which a human immune system is transplanted into a mouse lacking an immune system. Taken together, these results will yield databases from multiple biological systems that will be used in a mathematical modeling strategy for biomarker discovery and validation. Our consortium consists of partners from Austria, Turkey, Hungary, Ireland, Norway, and Australia and constitutes a diverse interdisciplinary team from veterinary medicine, nutrition, agriculture, immunology, and medicine that is dedicated to the development and validation of biomarkers to be used for post market monitoring of animals and humans consuming newly authorized GMOs.

Field of science

  • /natural sciences/computer and information sciences/databases
  • /medical and health sciences/health sciences/nutrition
  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /agricultural sciences/veterinary science
  • /medical and health sciences/basic medicine/immunology
  • /social sciences/economics and business/business and management/commerce

Call for proposal

FP7-KBBE-2007-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Address
Spitalgasse 23
1090 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 794 682,14
Administrative Contact
Michelle Epstein (Dr.)

Participants (7)

KOZPONTI ELELMISZER-TUDOMANYI KUTATOINTEZET

Participation ended

Hungary
Address
Herman Otto Ut 15
H-1022 Budapest
Activity type
Research Organisations
Administrative Contact
Erzsébet Némedi
NORGES VETERNINAERHOGSKOLE

Participation ended

Norway
Address
Ullevaalsveien 72
0033 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Eskil Aldal (Mr.)
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Australia
EU contribution
€ 22 500
Address
Clunies Ross Street Csiro Black Mountain Science And Innovation Park
2601 Acton Act
Activity type
Research Organisations
Administrative Contact
Helen Barker (Ms.)
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
EU contribution
€ 590 718
Address
Universitetstunet 3
1433 As
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Eskil Aldal (Mr.)
Agricultural Catchments Programme
Ireland
EU contribution
€ 617 449
Address
Oak Park
R93 Carlow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mark Ryan (Dr.)
NEMZETI AGRARKUTATASI ES INNOVACIOS KOZPONT
Hungary
EU contribution
€ 329 534
Address
Szent Gyorgyi Albert Utca 4
2100 Godollo
Activity type
Other
Administrative Contact
Zsuzsanna Farkas (Ms.)
TROYKA MAKINA GIDA INSAAT MUHENDISLIK ENERJI CEVRE BILISIM ARASTIRMA GELISTIRME DANISMANLIK SANAYI VE PAZARLAMA LIMITED SIRKETI

Participation ended

Turkey
EU contribution
€ 251 738,86
Address
Odtu Teknokent Ikizler Binasi
06531 Ankara
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nuri Akkas (Prof.)