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Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer

Objectif

The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives.

Appel à propositions

FP7-NMP-2007-LARGE-1
Voir d’autres projets de cet appel

Régime de financement

CP-IP - Large-scale integrating project

Coordinateur

FUNDACION GAIKER
Adresse
Parque Tecnologico De Vizcaya, Edificio 202
48170 Zamudio
Espagne
Type d’activité
Research Organisations
Contribution de l’UE
€ 1 187 724,90
Contact administratif
Oscar Salas (Mr.)

Participants (18)

TEL AVIV UNIVERSITY
Israël
Contribution de l’UE
€ 810 170,25
Adresse
Ramat Aviv
69978 Tel Aviv
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Lea Pais (Ms.)
PHARMAMAR, S.A.
Espagne
Contribution de l’UE
€ 332 380,50
Adresse
Avda. De Los Reyes , Poligono Industrial La Mina 1
28770 Colmenar Viejo (Madrid)
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Elena Calleja (Ms.)
FEYECON DEVELOPMENT & IMPLEMENTATION BV
Pays-Bas
Contribution de l’UE
€ 121 800
Adresse
Rijnkade 17 A
1382 GS Weesp
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Annet. Helena Butter-Duits (Ms.)
CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI
Italie
Contribution de l’UE
€ 951 284
Adresse
Via Giusti 9
50121 Firenze
Type d’activité
Research Organisations
Contact administratif
Daniele Consigli (Mr.)
AHAVA DEAD SEA LABORATORIES LTD
Israël
Contribution de l’UE
€ 256 492,50
Adresse
Arava Street 1
70150 Airport City
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Ofer Achdut (Mr.)
ASOCIACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES-VICOMTECH
Espagne
Contribution de l’UE
€ 347 662,50
Adresse
Paseo Mikeletegi Parque Tecnologico De Miramon 57
20009 Donostia / San Sebastian
Type d’activité
Research Organisations
Contact administratif
Grégory Maclair (Dr.)
COLOROBBIA ITALIA SPA
Italie
Contribution de l’UE
€ 505 700
Adresse
Via Pietramarina 53
50059 Sovigliana Vinci
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Laura Niccolai (Dr.)
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Espagne
Contribution de l’UE
€ 288 315
Adresse
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Type d’activité
Research Organisations
Contact administratif
Alfonso Egaña (Mr.)
DOMINION PHARMAKINE S.L.

Participation terminée

Espagne
Contribution de l’UE
€ 158 295,05
Adresse
Bizkaia Technology Park Building 801A
48160 Derio
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Naiara Telleria (Dr.)
JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION
Belgique
Contribution de l’UE
€ 405 051
Adresse
Rue De La Loi 200
1049 Brussels
Type d’activité
Research Organisations
Contact administratif
Clemens Wittwehr (Mr.)
HAMELN RDS AS
Slovaquie
Contribution de l’UE
€ 275 734,43
Adresse
Horna 36
900 01 Modra
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Anna Kovácová (Ms.)
INSTITUT POLYTECHNIQUE DE BORDEAUX
France
Contribution de l’UE
€ 952 208,72
Adresse
Av Du Docteur Albert Schweitzer 1
33402 Talence
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Sebastien Lecommandoux (Prof.)
TECHNOLOGIKO EKPAIDEFTIKO IDRYMA ATHINAS
Greece
Contribution de l’UE
€ 342 840
Adresse
Agiou Spyridonos 28 Kai Milou 1
122 10 Aigaleo
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Ifigenia Anastasakou (Ms.)
UNIVERSITE VICTOR SEGALEN BORDEAUX II
France
Contribution de l’UE
€ 326 016
Adresse
Rue Leo Saignat 146
33076 Bordeaux Cedex
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jean-Michel Franconi (Prof.)
NuovoProbe Ltd
United Kingdom
Contribution de l’UE
€ 278 692
Adresse
Wigmore Street 128
W1U 3SA London
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Liz Spencer (Ms.)
ARGUS CHEMICAL SRL
Italie
Contribution de l’UE
€ 120 848,15
Adresse
Via Del Molin Nuovo 10
59024 59024
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Enrico Ammannati (Dr.)
AYMING
France
Contribution de l’UE
€ 343 880
Adresse
Rue Chaptal 114
92300 Levallois-perret
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Nicolas Marin (Mr.)
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Espagne
Contribution de l’UE
€ 403 388
Adresse
Carrer De La Innovacio 2
08225 Terrassa
Type d’activité
Research Organisations
Contact administratif
Ciro Avolio (Mr.)