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Radiochemistry on chip

Ziel

The aim of this project is the design, fabrication and implementation of a microdevice able to synthesise radiopharmaceuticals for Positron Emission Tomography (PET) analysis, a technique usually employed in medicine for its unsurpassed sensitivity and specificity. We propose to develop a modular microfluidic architecture which can be used for standard synthesis protocols as well as for R&D of new radiopharmaceuticals. In order to achieve this target, emerging technologies in the field of micro reactors and micro total analysis systems (μ–TAS) have to be applied to the synthetic pathways typical for radiopharmaceuticals, thus improving the traditional approach in terms of efficiency and safety. A deep knowledge of the chemical processes and of the separation techniques involved in radiosynthesis is needed to define the features of the modules to be fabricated as well as state of art techniques in the field of micro fabrications and microfluidics for the implementation of high performance micro devices. Standard synthesis protocols and new radiopharmaceuticals will be carried into the micro devices thus evaluating their efficiency and versatility. The yields and the purity of the products produced into micro devices will be compared with those obtained with traditional methods and tested in vivo for Positron Emission Tomography (PET) analysis. To ensure the success of the overall project, we will take advantage of a strict collaboration between chemists, physics and engineers in an interdisciplinary approach. For this purpose, we built an international network collaboration between academic partners dealing with the technological side, an industrial partner for checking the system robustness and a physiological clinical institute able to evaluate the end-user outcome.

Aufforderung zur Vorschlagseinreichung

FP7-NMP-2007-SMALL-1
Andere Projekte für diesen Aufruf anzeigen

Koordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Adresse
Piazzale Aldo Moro 7
00185 Roma
Italien

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Paola Corezzola (Ms.)
EU-Beitrag
€ 859 091

Beteiligte (5)

UNIVERSITY OF HULL
United Kingdom
EU-Beitrag
€ 558 264
Adresse
Cottingham Road
HU6 7RX Hull

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Paul Watts (Dr.)
LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV

Beteiligung beendet

Deutschland
EU-Beitrag
€ 155 225
Adresse
Bunsen Kirchhoff Strasse 11
44139 Dortmund

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Jasmin Gleissner (Ms.)
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Irland
EU-Beitrag
€ 436 830
Adresse
Western Road
T12 YN60 Cork

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Conor Delaney (Mr.)
SIEMENS AKTIENGESELLSCHAFT
Deutschland
EU-Beitrag
€ 457 076
Adresse
Werner-von-siemens-str. 1
80333 Munchen

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Carolin Smolak (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Schweiz
EU-Beitrag
€ 233 426
Adresse
Raemistrasse 101
8092 Zuerich

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Petra Dittrich (Prof.)