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Radiochemistry on chip

Obiettivo

The aim of this project is the design, fabrication and implementation of a microdevice able to synthesise radiopharmaceuticals for Positron Emission Tomography (PET) analysis, a technique usually employed in medicine for its unsurpassed sensitivity and specificity. We propose to develop a modular microfluidic architecture which can be used for standard synthesis protocols as well as for R&D of new radiopharmaceuticals. In order to achieve this target, emerging technologies in the field of micro reactors and micro total analysis systems (μ–TAS) have to be applied to the synthetic pathways typical for radiopharmaceuticals, thus improving the traditional approach in terms of efficiency and safety. A deep knowledge of the chemical processes and of the separation techniques involved in radiosynthesis is needed to define the features of the modules to be fabricated as well as state of art techniques in the field of micro fabrications and microfluidics for the implementation of high performance micro devices. Standard synthesis protocols and new radiopharmaceuticals will be carried into the micro devices thus evaluating their efficiency and versatility. The yields and the purity of the products produced into micro devices will be compared with those obtained with traditional methods and tested in vivo for Positron Emission Tomography (PET) analysis. To ensure the success of the overall project, we will take advantage of a strict collaboration between chemists, physics and engineers in an interdisciplinary approach. For this purpose, we built an international network collaboration between academic partners dealing with the technological side, an industrial partner for checking the system robustness and a physiological clinical institute able to evaluate the end-user outcome.

Invito a presentare proposte

FP7-NMP-2007-SMALL-1
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Meccanismo di finanziamento

CP-FP - Small or medium-scale focused research project

Coordinatore

CONSIGLIO NAZIONALE DELLE RICERCHE
Indirizzo
Piazzale Aldo Moro 7
00185 Roma
Italia
Tipo di attività
Research Organisations
Contributo UE
€ 859 091
Contatto amministrativo
Paola Corezzola (Ms.)

Partecipanti (5)

UNIVERSITY OF HULL
United Kingdom
Contributo UE
€ 558 264
Indirizzo
Cottingham Road
HU6 7RX Hull
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Paul Watts (Dr.)
LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV

Partecipazione conclusa

Germania
Contributo UE
€ 155 225
Indirizzo
Bunsen Kirchhoff Strasse 11
44139 Dortmund
Tipo di attività
Research Organisations
Contatto amministrativo
Jasmin Gleissner (Ms.)
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Irlanda
Contributo UE
€ 436 830
Indirizzo
Western Road
T12 YN60 Cork
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Conor Delaney (Mr.)
SIEMENS AKTIENGESELLSCHAFT
Germania
Contributo UE
€ 457 076
Indirizzo
Werner-von-siemens-str. 1
80333 Munchen
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Carolin Smolak (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Svizzera
Contributo UE
€ 233 426
Indirizzo
Raemistrasse 101
8092 Zuerich
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Petra Dittrich (Prof.)