Objective
"CD8+ T cells are fundamental targets for improved vaccination strategies, since they are fundamental to virus and tumors control, and current immunization protocols to generate efficient CD8+ responses are essentially inadequate. Major handicaps are the l ack of correlation between the current tests used to study CD8+ T cell function and infection out-come or efficient memory generation. The present project will study responses and memory using new methodological advancements that should allow efficient cha racterization of CD8+ differentiation programs. Functional profiles will be defined using a new methodology developed in the host laboratory, that allows the simultaneous quantification of 20 relevant gene products expression in each individual antigen-spe cific CD8+ T cell ex-vivo. We will study the impact of different immunization protocols, studying the same clone of T cell receptor (TCR) transgenic (Tg) cells responding to the same antigen presented in different forms, i.e. cells expressing naturally th e antigen, mature and immature dendritic cells loaded ¿in vitro¿ with peptide or recombinant Listeria expressing the same antigen. To evaluate the impact of TCR affinity, we will also study the responses to the same immunization protocol of different T cel l clones, covering a large range of TCR affinities. Finally we will evaluate the role of IL-7R in memory T cell generation. We developed IL-7R Tg mice that cannot down regulate IL7R during immune responses. IL-7R expression is essential for peripheral T ce ll survival, but the reason for its down-regulation upon T cell activation and the mode of its re-expression in memory T cells is obscure. The study of immune responses in these Tg mice will provide definitive answers on the role IL-7R expression in CD8+ m emory generation. Moreover, together with 31 European laboratories associated into the EU network #512074 this study will allow a detailed genetic mapping of CD8+ memory cell differentiation."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.