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NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY

Objectif

Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with pathogenesis of different human diseases, including cancer. NotchIT integrates the research and training activities of the eight different partners, who are all leaders in Notch signaling and related fields, to specifically address three strategic initiatives, which are central to European science and health economy: - the core Notch signaling mechanism with the purpose of constructing a state-of-the-art molecular tool box for Notch signaling and to disseminate this knowledge and reagents at a pan-European level. - the role of Notch signaling in the differentiation and pathology of various cell types with the purpose of using Notch signaling to improve our means to steer stem cell differentiation and to correct aberrant Notch signaling in pathologies. - how Notch signaling can be exogenously controlled through pharmacological approaches, in order to break new ground and to ultimately design new diagnostic and therapeutic protocols. The training component in NotchIT is deeply integrated with the research programme. The partners in NotchIT possess a wide range of expertise and work in operationally diverse environments: Hospitals, Universities, Research Institutes and Industry. This broad knowledge-base, combined with an integrated set of courses, workshops, meetings and cross-laboratory visits, provides an excellent training opportunity for early stage and experienced scientists in the center, and will prepare them for high level positions in academia and industry.

Appel à propositions

FP7-PEOPLE-2007-1-1-ITN
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Régime de financement

MC-ITN - Networks for Initial Training (ITN)

Coordinateur

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Adresse
Piazzale Aldo Moro 5
00185 Roma
Italie
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 716 306,80
Contact administratif
Giancarlo Bertea (Mr.)

Participants (9)

THE UNIVERSITY OF EDINBURGH
United Kingdom
Contribution de l’UE
€ 510 686
Adresse
Old College, South Bridge
EH8 9YL Edinburgh
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Angela Noble (Ms.)
KAROLINSKA INSTITUTET
Suède
Contribution de l’UE
€ 446 285,40
Adresse
Nobels Vag 5
17177 Stockholm
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Riitta Ljungström (Ms.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Suisse
Contribution de l’UE
€ 444 347,70
Adresse
Batiment Ce 3316 Station 1
1015 Lausanne
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Catherine Pache (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Contribution de l’UE
€ 401 953,19
Adresse
Rue De Tolbiac 101
75654 Paris
Type d’activité
Research Organisations
Contact administratif
Isabelle Lopes (Ms.)
INSTITUT PASTEUR
France
Contribution de l’UE
€ 190 763,10
Adresse
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Type d’activité
Research Organisations
Contact administratif
Nadia Khelef (Dr.)
NEWRON SWEDEN AB

Participation terminée

Suède
Adresse
Fiskartorpsvagen 15 A D
114 33 Stockholm
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Henrik Resmark (Mr.)
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Espagne
Contribution de l’UE
€ 419 648,90
Adresse
Calle Melchor Fernandez Almagro 3
28029 Madrid
Type d’activité
Research Organisations
Contact administratif
Stefan Jungbluth (Dr.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Participation terminée

Espagne
Adresse
Calle Serrano 117
28006 Madrid
Type d’activité
Research Organisations
Contact administratif
ACTAR AB
Suède
Contribution de l’UE
€ 330 008,91
Adresse
Nobels Vaeg 3
171 77 Stockholm
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Jonas Ekstrand (Dr.)