Objective
Contact hypersensitivity (CHS) response is clinically known as allergic contact dermatitis, which affects about 5% of men and 11% of women in industrialized countries and is one of the leading causes of occupational diseases. CHS is a classical example of an adaptive immune response, in which T cells and B-1 B cells have been shown to play a role. Natural Killer (NK) cells had been generally believed to mediate only innate immune responses. However, the von Andrian laboratory reported new observations indicating that NK cells can also mediate CHS as an antigen (Ag)-specific, long lasting adaptive response in mice independent of B and T cells. Adoptive transfer experiments showed that only hepatic NK cells are capable of causing this CHS response. In this project, we propose to investigate the trafficking of hepatic NK cells and their education by antigen presenting cells (APC). Specifically, we plan to understand where and how NK cells learn to recognize hapten-based Ag to induce a specific CHS response. Moreover, we will examine whether regulatory T (Treg) cells can modulate the activity of NK cells during the NK-mediated CHS response. Some evidence in the literature indicates that Treg cells do play a role during αβ T cell-mediated CHS by mechanisms that are still unclear. Whether Treg cells also play a role during NK cell-mediated CHS is unknown. The von Andrian laboratory has established state-of-the-art multiphoton microscopy technology and extensive expertise in intravital imaging, which will allow us to study cell trafficking in anesthetized animals. Using transgenic mice and adoptive transfer of fluorescently labeled leukocyte subsets, we will study in vivo the cross talk between APC and NK cells and between Treg and NK cells during the priming and effector phase of CHS. This project will contribute to our understanding of how adaptive and innate immunity is coordinated, thereby potentially allowing the development of novel approaches to immunotherapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-1-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.