Objective
Platelets play a central role in arterial thrombosis, causing life-threatening and disabling diseases like myocardial infarction and ischemic stroke. Despite antiplatelet therapies have been proven efficacious for primary and secondary prevention of cardio- and cerebrovascular diseases, arterial thrombosis remains a major healthy problem. A better understanding of the multiple mechanisms by which platelets can be activated is the basis for the rationale development of new antithrombotic drugs. The “outgoing” host institution involved in this project has previously demonstrated that protease-activated receptor (PAR) signaling in platelets is necessary for platelet activation by thrombin and important for hemostasis and thrombosis in mouse models. These results have greatly contributed to the development of a PAR1 antagonist, that has been recently used as antithrombotic drug in a phase II trial . The objectives of this proposal are to better define the role of thrombin signaling in vivo and to explore how the thrombin-PARs pathway relates to other effectors of hemostasis and thrombosis. This study will make use of mouse models of hemostasis and thrombosis. In the partner institution the generation of knockout mice for multiple platelet receptors (glycoprotein VI, FcγR, P2Y12 ) and other relevant molecules for hemostasis and thrombosis (vonWillebrand factor, FIX, FXI, fibrinogen) is ongoing. On those mice the following endpoints will be evaluated 1) hemostasis (bleeding time, neonatal hemorrhage, placentation, maternal hemorrhage, anemia) 2) thrombosis (by using a ferric chloride injury to induce carotid or mesenteric thrombosis). This project will allow the researcher to gain knowledge and experience on the in vivo models of hemostasis and thrombosis. This will be relevant for the fellowship program since the in vivo models will be set up during the return phase in the host institution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine hematology
- medical and health sciences basic medicine neurology stroke
- medical and health sciences clinical medicine angiology vascular diseases cerebrovascular diseases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-1-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20123 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.