Objectif Dysregulation of lipid homeostasis is related to multiple major global healthcare problems today, including aging, diabetes and cardiovascular disease. It has already been shown that nutritional modulation of lipid homeostasis via direct supplementation, e.g. n-3 fatty acids, or via indirect mechanisms, e.g. dietary polyphenols, has beneficial effects on human health. There is growing evidence that ether phospholipids such as plasmalogens play a central role in mediating the beneficial effects, but the underlying mechanisms are not understood. ETHERPATHS will develop systems biology tools that will facilitate studies of dietary interventions aiming to modulate lipid homeostasis. Specifically, we will develop (1) models that enable studies of gut microbiota and its effect on host cell metabolism, (2) dynamic models of systemic lipid metabolism, and (3) pathway reconstruction methods to study tissue-specific effects of dietary interventions. All models will be optimized in the context of studies of dietary interventions and will be integrated into a sophisticated software platform. In silico strategies will be complemented by multiple experimental approaches, including (1) dietary interventions involving n-3 fatty acids and polyphenols, combined with tracer studies in vitro and in vivo (2) in vitro colon model (3) in vivo germ-free and conventional models of altered lipid metabolism, specifically of plasmalogen deficiency. ETHERPATHS includes academic and industrial partners with combined unique expertise in information technology, bioinformatics, metabolic and physiological modelling, systems engineering, biochemistry, microbiology, lipid metabolism, metabolomics, obesity and metabolic syndrome, and clinical nutrition. We expect the ETHERPATHS tools to be broadly applied in nutrition research, and anticipate that the novel findings generated within the project will be applied for development of new food products for better health. Champ scientifique medical and health sciencesclinical medicineendocrinologydiabetesnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Mots‑clés bioinformatics gut microflora lipidomics metabolomics systems biology Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Thème(s) KBBE-2007-2-2-08 - Systems Biology and bioanalytical tools for nutrition research Appel à propositions FP7-KBBE-2007-2A Voir d’autres projets de cet appel Régime de financement CP-IP - Large-scale integrating project Coordinateur TEKNOLOGIAN TUTKIMUSKESKUS VTT Contribution de l’UE € 1 893 298,00 Adresse TEKNIIKANTIE 4 A 02044 VTT ESPOO Finlande Voir sur la carte Type d’activité Research Organisations Contact administratif Sinikka Soirinsuo (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (9) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITAT DE BARCELONA Espagne Contribution de l’UE € 633 921,00 Adresse GRAN VIA DE LES CORTS CATALANES 585 08007 Barcelona Voir sur la carte Région Este Cataluña Barcelona Type d’activité Higher or Secondary Education Establishments Contact administratif Marta Cascante (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GOETEBORGS UNIVERSITET Suède Contribution de l’UE € 1 313 312,00 Adresse VASAPARKEN 405 30 Goeteborg Voir sur la carte Région Södra Sverige Västsverige Västra Götalands län Type d’activité Higher or Secondary Education Establishments Contact administratif Margareta Ahlqwist (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Royaume-Uni Contribution de l’UE € 657 413,00 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Contact administratif Edna Murphy (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Institute for Systems Biology SPb Company Limited Russie Contribution de l’UE € 314 586,00 Adresse Toreza avenue, 80, 48 194017 saint-Petersburg Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Victor Shumilkin (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italie Contribution de l’UE € 687 300,00 Adresse CORSO UMBERTO I, 40 80138 Napoli Voir sur la carte Région Sud Campania Napoli Type d’activité Higher or Secondary Education Establishments Contact administratif Anna Pafundi (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée NORAY BIOINFORMATICS SL Espagne Contribution de l’UE € 348 396,00 Adresse PARQUE TECNOLOGICO 801A 48160 DERIO Voir sur la carte Région Noreste País Vasco Bizkaia Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Maria Unzurrunzaga (Ms.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée BIOMOTIF AB Suède Contribution de l’UE € 98 400,00 Adresse WANNING KOMETVAGEN 17 18348 Stockholm Voir sur la carte Région Östra Sverige Stockholm Stockholms län Contact administratif Thorleif Lavold (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Advion BioSciences Ltd Royaume-Uni Contribution de l’UE Aucune donnée Adresse Rowan House Queens Road Hethersett 26 NR31 7RU Great Yarmouth Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Mark Allen (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée NESTEC S.A Suisse Contribution de l’UE Aucune donnée Adresse Avenue Nestle 55 1800 VEVEY Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Chantal Grosjean (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée