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Characterization and modelling of dietary effects mediated by gut microbiota on lipid metabolism

Cel

Dysregulation of lipid homeostasis is related to multiple major global healthcare problems today, including aging, diabetes and cardiovascular disease. It has already been shown that nutritional modulation of lipid homeostasis via direct supplementation, e.g. n-3 fatty acids, or via indirect mechanisms, e.g. dietary polyphenols, has beneficial effects on human health. There is growing evidence that ether phospholipids such as plasmalogens play a central role in mediating the beneficial effects, but the underlying mechanisms are not understood. ETHERPATHS will develop systems biology tools that will facilitate studies of dietary interventions aiming to modulate lipid homeostasis. Specifically, we will develop (1) models that enable studies of gut microbiota and its effect on host cell metabolism, (2) dynamic models of systemic lipid metabolism, and (3) pathway reconstruction methods to study tissue-specific effects of dietary interventions. All models will be optimized in the context of studies of dietary interventions and will be integrated into a sophisticated software platform. In silico strategies will be complemented by multiple experimental approaches, including (1) dietary interventions involving n-3 fatty acids and polyphenols, combined with tracer studies in vitro and in vivo (2) in vitro colon model (3) in vivo germ-free and conventional models of altered lipid metabolism, specifically of plasmalogen deficiency. ETHERPATHS includes academic and industrial partners with combined unique expertise in information technology, bioinformatics, metabolic and physiological modelling, systems engineering, biochemistry, microbiology, lipid metabolism, metabolomics, obesity and metabolic syndrome, and clinical nutrition. We expect the ETHERPATHS tools to be broadly applied in nutrition research, and anticipate that the novel findings generated within the project will be applied for development of new food products for better health.

Zaproszenie do składania wniosków

FP7-KBBE-2007-2A
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Koordynator

TEKNOLOGIAN TUTKIMUSKESKUS VTT
Adres
Tekniikantie 4 A
02044 VTT Espoo
Finlandia

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Rodzaj działalności
Research Organisations
Kontakt administracyjny
Sinikka Soirinsuo (Ms.)
Wkład UE
€ 1 893 298

Uczestnicy (9)

UNIVERSITAT DE BARCELONA
Hiszpania
Wkład UE
€ 633 921
Adres
Gran Via De Les Corts Catalanes 585
08007 Barcelona

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Higher or Secondary Education Establishments
Kontakt administracyjny
Marta Cascante (Prof.)
GOETEBORGS UNIVERSITET
Szwecja
Wkład UE
€ 1 313 312
Adres
Vasaparken
405 30 Goeteborg

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Margareta Ahlqwist (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Wkład UE
€ 657 413
Adres
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Edna Murphy (Ms.)
Institute for Systems Biology SPb Company Limited
Rosja
Wkład UE
€ 314 586
Adres
Toreza Avenue, 80, 48
194017 Saint-petersburg

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Victor Shumilkin (Dr.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Włochy
Wkład UE
€ 687 300
Adres
Corso Umberto I, 40
80138 Napoli

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Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Anna Pafundi (Dr.)
NORAY BIOINFORMATICS SL
Hiszpania
Wkład UE
€ 348 396
Adres
Parque Tecnologico 801a
48160 Derio

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Maria Unzurrunzaga (Ms.)
BIOMOTIF AB
Szwecja
Wkład UE
€ 98 400
Adres
Wanning Kometvagen 17
18348 Stockholm

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Thorleif Lavold (Mr.)
Advion BioSciences Ltd
United Kingdom
Adres
Rowan House Queens Road Hethersett 26
NR31 7RU Great Yarmouth

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Mark Allen (Dr.)
NESTEC S.A
Szwajcaria
Adres
Avenue Nestle 55
1800 Vevey

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Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Chantal Grosjean (Ms.)