Objective The NEuroStemCell consortium will foster collaboration between leading European experimental and clinical researchers in order to maximise the prospects for successful clinical trials of stem cell therapy for Parkinson's (PD) and Huntington's (HD) Disease. The activities will be driven by a Clinical WorkPackage (WP), which will set the requirements, and monitor and guide advances in development of the most promising cells. The goal is to compare different stem cell sources with respect to their capcity to generate mesencephalic Dopaminergic and striatal GABAergic neurons suitable for neuronal cell replacement. The major sources will be neuralised Embryonic Stem (ES) cells, adherent Neural Stem (NS) cell lines and short term expanded Ventral Midbrain neural stem cells/progenitors grown as Neurospheres (VMN). Two exploratory WPs will use extrinsic cues to specify neuronal differentiation and compare rigorously the different human stem cell lines and their progeny in giving rise to authentic neurons. WP3 will integrate long-term assessements of functional (motor and cognitive) recovery in appropriate animal models of PD and HD, and WP4 will exploit non-invasive in vivo imaging to evaluate the survival, composition, integration and functional impact of the donor cells in host brain. These two WPs will also provide the elements necessary to standardise the extent of recovery as a function of cell replacement and integration. In WP5, three SMEs will generate the technologies for manufacturing and scale-up of safe, fully traceable, efficacious and banked stocks of cells ready for clinical use. Regulatory and ethical requirements will be considered in the Clinical WP which also incorporates training. Building on the successful experience of the FPVI EuroStemCell project, NEuroStemCell will provide a focal point for European researchers engaged in the translational aspects of stem cell-based strategies to develop cures for PD and HD Fields of science medical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurologyparkinson Keywords Cell Banks Cell Therapy Huntington Parkinson Stem cell lines Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.4-6 - Stem cell lines for cell-based therapies Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITA DEGLI STUDI DI MILANO EU contribution € 2 126 232,12 Address Via Festa Del Perdono 7 20122 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Gianni Munizza (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all MAX IV Laboratory, Lund University Sweden EU contribution € 2 290 423,40 Address Paradisgatan 5c 22100 LUND See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Paulina Pettersson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM BONN Germany EU contribution € 1 073 760,00 Address VENUSBERG-CAMPUS 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Gieselmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 1 383 976,60 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Riitta Ljungström (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CARDIFF UNIVERSITY United Kingdom EU contribution € 910 440,87 Address NEWPORT ROAD 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Administrative Contact Nick Bodycombe (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 600 000,00 Address RUE LEBLANC 25 75015 PARIS 15 See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Olivier Leroy (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 875 000,00 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Dawn Barker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 950 000,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Evelyne Lasfargues (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Participation ended United Kingdom EU contribution € 442 605,92 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Michael Robinson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOREP SRL Italy EU contribution € 560 000,00 Address GALLERIA PASSARELLA 2 20122 MILANO See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Pancrazio Soldan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NSGENE AS Denmark EU contribution € 415 000,00 Address BALTORPVEJ 154 2750 BALLERUP See on map Region Danmark Hovedstaden Københavns omegn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bengt Juliusson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Stem Cell Sciences PLC Participation ended United Kingdom EU contribution € 9 084,48 Address Babraham Research Campus, Meditrina Building 260 CB22 3AT Cambridge See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Lorna Peers (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Sloan-Kettering Institute for Cancer Research CORPORATION United States EU contribution € 263 476,61 Address York Avenue 1275 10065 New York See on map Activity type Research Organisations Administrative Contact Saint Germain Jason (Mr.) Links Contact the organisation Opens in new window Total cost No data
