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Translational Research on Combating Antimicrobial Resistance

Objective

The health care systems of most European countries are based on a continuum from acute care hospitals, though other health care facilities to the community. Such a framework provides the perfect opportunity for the wide-spread dissemination of high-risk resistant clones or genetic resistant elements. The driving concept of TROCAR is to investigate the fundamentals of the epidemiology of new highly virulent multiresistant strains of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus spp., Extended-spectrum, metallo- and acquired AmpC beta-lactamase producing Enterobacteriaceae, multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii will focus on three major strategic aims: 1. The definition of the major high-risk resistant clones based on an appropriate representative collection and new clinical strains obtained during molecular epidemiological studies, in hospitals and laboratories collaborating with their respective National Excellence Laboratories in European countries using a standardised protocol. 2. The promotion of collaborative European research to investigate, by genomic and proteomic approaches, specific traits associated with virulence, transmission, persistence and resistance of epidemic clones in comparison with non-epidemic clones as well as resistance determinants and their genetic location in horizontal gene transfer units and their genetic environment. 3. The development of bioinformatics tools to fully exploit the genomics data and allow the rapid identification of resistant strains with heightened epidemic potential. By combining the outputs of the project it will be possible to provide tools for monitoring the spread of key community and nosocomial pathogens, to provide the scientific basis for an early warning system when isolates of a particular epidemicity appear in the community and nosocomial settings, to characterise specific genetic elements carrying resistance genes encoding, and to establish t

Field of science

  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Spain
Activity type
Other
EU contribution
€ 593 501
Administrative Contact
Ramon Gomis (Prof.)

Participants (13)

INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
Portugal
EU contribution
€ 192 012
Address
Avenida Da Republica, Estacao Agronomica Nacional
2784-505 Oeiras
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margarida Martinez (Dr.)
UNIVERSITE DE CAEN NORMANDIE
France
EU contribution
€ 235 458
Address
Esplanade De La Paix
14032 Caen Cedex 5
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Josette Travert (Prof.)
ETHNIKI SCHOLI DIMOSIAS YGEIAS
Greece
EU contribution
€ 167 250
Address
Leoforos Alexandras 196
11521 Athens
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anastasia Roumelioti (Prof.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 211 500
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
Administrative Contact
Jaakko Penttinen (Mr.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 240 900
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silvano Focardi (Prof.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 216 000
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan.J. Breeuwsma (Dr.)
EUROPEAN SOCIETY OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES E.V
Germany
EU contribution
€ 66 000
Address
Hainbuchenstrasse 65
8000 Munchen 80
Activity type
Research Organisations
Administrative Contact
Barbara Siegrist (Ms.)
UNIVERSITE PARIS-SUD
France
EU contribution
€ 198 000
Address
Rue Georges Clemenceau 15
91405 Orsay Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sandra Mereu (Ms.)
UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 175 500
Address
Claverton Down
BA2 7AY Bath
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pete Hompstead (Mr.)
ROBERT KOCH-INSTITUT
Germany
EU contribution
€ 155 898
Address
Nordufer 20
13353 Berlin
Activity type
Research Organisations
Administrative Contact
Wolfgang Witte (Prof.)
Public Health England an Executive Agency of the Dept of Health
United Kingdom
EU contribution
€ 213 426
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Geetha Naathan (Ms.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 234 000
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Isabel Crespo (Ms.)
SISTEMAS GENOMICOS SL
Spain
EU contribution
€ 99 999
Address
Ronda G Marconi - Parque Tecnologico De Valencia 6
46980 Paterna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David García Alfonso (Mr.)