Objectif The research program aims to understand the dynamics of the structural and functional organization of the visual cortex and the implications for amblyopia ('lazy eye', the most prevalent visual disorder among young people). We will study these fundamental issues from the molecular level all the way to the network level. To achieve this, members of the consortium have - for the first time - established chronic in vivo two photon imaging of Ca2+ responses in the visual cortex by making use of a novel genetically encoded Ca2+ sensor. Using this powerful new methodology we will study how experience changes firing properties of individual neurons of known identity and how this correlates with changes in inhibitory and excitatory synaptic structures. Using the same approach we will study the neuronal substrate of amblyopia and how it alters coding of visual information. Next we will study how binocular experience leads to recovery from amblyopia and how perceptual learning can improve this in animal models and human subjects. This knowledge will be directly translated into new treatments of amblyopia by one of the participating SMEs. Last we will study the molecular and cellular mechanisms that restrict plasticity in the adult visual system with the aim to achieve increased experience dependent plasticity in the adult brain. This knowledge can be used for the treatment of disorders of the CNS from which recovery is limited due to restricted plasticity. Apart from amblyopia, these include brain tumors, stroke, degenerative diseases and trauma. Together this program will provide comprehensive insight into the neuronal interactions underpinning function and dysfunction of the visual cortex and will contribute directly to improved treatment of amblyopia and development of plasticity based approaches for curing a large array of disorders of the CNS. Champ scientifique engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesbasic medicineneurologystrokenatural sciencesphysical sciencestheoretical physicsparticle physicsphotons Mots‑clés amblyopia calcium responses ocular dominance plasticity strabismus two photon imaging visual cortex Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.2.1-9 - Neuronal mechanisms of vision and related diseases Appel à propositions FP7-HEALTH-2007-B Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Contribution de l’UE € 522 128,00 Adresse KLOVENIERSBURGWAL 29 HET TRIPPENHUIS 1011 JV AMSTERDAM Pays-Bas Voir sur la carte Région West-Nederland Noord-Holland Groot-Amsterdam Type d’activité Research Organisations Contact administratif Rikesh Balgobind (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Allemagne Contribution de l’UE € 656 632,00 Adresse HOFGARTENSTRASSE 8 80539 Munchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Research Organisations Contact administratif Annette Starke (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITY COLLEGE LONDON Contribution de l’UE € 357 204,00 Adresse GOWER STREET WC1E 6BT LONDON Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Kent Lee (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI FIRENZE Italie Contribution de l’UE € 346 560,00 Adresse Piazza San Marco 4 50121 Florence Voir sur la carte Région Centro (IT) Toscana Firenze Type d’activité Higher or Secondary Education Establishments Contact administratif Cristina Stefanile (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CARDIFF UNIVERSITY Royaume-Uni Contribution de l’UE € 269 531,00 Adresse NEWPORT ROAD 30 36 CF24 0DE Cardiff Voir sur la carte Région Wales East Wales Cardiff and Vale of Glamorgan Type d’activité Higher or Secondary Education Establishments Contact administratif Nick Bodycombe (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BITPLANE AG Suisse Contribution de l’UE € 159 749,00 Adresse BADENERSTRASSE 682 8048 ZUERICH Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Bernard Quinn (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MINDWEAVERS PLC Participation terminée Royaume-Uni Contribution de l’UE Aucune donnée Adresse MILL STREET OX2 0JX OXFORD Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Bruce Robinson (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE UNIVERSITY OF NOTTINGHAM Royaume-Uni Contribution de l’UE € 287 102,00 Adresse University Park NG7 2RD Nottingham Voir sur la carte Région East Midlands (England) Derbyshire and Nottinghamshire Nottingham Type d’activité Higher or Secondary Education Establishments Contact administratif Paul Cartledge (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée