Projektbeschreibung
Photonic components and subsystems
InTopSens is a multidisciplinary project involving the emerging fields of photonics structures, electronics, fluidics and bio-chemistry, to contribute to the development of high value sensor technology. This objective will be addressed through the demonstration of a compact polymer and silicon-based CMOS-compatible photonics sensor system. It integrates two label-free biomolecular recognition photonic sensor technologies with sensitivities as low as 0.1ng per ml, state-of-the-art in label-free integrated optical biosensors, with novel coupling technology that will permit very high integration of hundreds of sensing areas on a 1mm2 photonics chip. This offers the further advantageous possibility of assaying several parameters simultaneously leading to further increases in the reliability and reductions in the measurement uncertainty of a diagnostic over single-parameter assays. The novel diagnostic technology of the InTopSens device has the potential to be fast and easy to use, making routine screening or monitoring of bacteria more cost-effective. The ultimate target of InTopSens is to demonstrate the feasibility of a rapid diagnostic test for sepsis at 'point of care'. From the introduction onto the chip of a large drop of blood (some 5ml) it will have after 5-10 mins a yes/no to the presence of bacteria and after less than 30mins an antibiotic resistance profile of the infecting bacteria. Some 120 sensing areas/datapoints are needed to identify this profile and as such due to the very high integration up to 250 assays can be integrated onto a 1mm2 chip for the same bacteria for higher sensitivity/selectivity or for other bacteria. A final prototype consisting of a packaged biochip will be used on clinical samples in order to detect the sepsis bacteria and determine their resistance to antibiotics.
Wissenschaftliches Gebiet
- natural sciencesbiological sciencesmicrobiologybacteriology
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensors
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- engineering and technologymedical engineeringmedical laboratory technologydiagnostic technologies
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
FP7-ICT-2007-2
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Finanzierungsplan
CP - Collaborative project (generic)Kontakt Koordinator
Koordinator
100 44 Stockholm
Schweden