Skip to main content

Interplay of microbiota and gut function in the developing pig – Innovative avenues towards sustainable animal production

Objective

Low input farming occurs under non-SPF (specific pathogen free) conditions. The European ban on in-feed antibiotics exposes the piglets to a higher microbial environmental pressure. The postnatal priming of piglets with a diverse microbiota may affect the development of the piglet’s host-defense and gut functionality. By reversal, the piglets developing host-defense may affect the development of the gastro-intestinal microbiota. Moreover, this intricate interplay between gut microbiota and its host during the early phases of life is expected to also affect animal health and performance later in life. The gut microbiome is an immensely diverse ecosystem that has co-evolved with its host. Recent research on microbe-host interactions has provided novel insights into the role of commensal intestinal microbes in several physiological processes, i.e., from epithelial barrier development to immune development as well as neurological aspects. Nevertheless, we only start to understand the molecular mechanisms of the host microbe cross-talk. Recent conceptual as well as technological advances have set the stage for the integrated application of a complementary set of high throughput approaches for the comprehensive profiling of GIT microbiota composition and functionality as well as the animal’s intestinal function. In a multidisciplinary consortium, comprising 11 public and private partners from across and beyond Europe with complementary expertise in gut microbiomics, immunology and physiology, and animal genomics and nutrition, INTERPLAY will apply an integrated approach to arrive at a sound understanding of the interaction of early colonization of the intestine and the development of gut function. This knowledge will be exploited for the identification of innovative management strategies that address host genotype as well as nutritional means to provide a framework for sustainable animal production at high food and consumer safety and improved animal health and welfare.

Field of science

  • /social sciences/economics and business/economics/sustainable economy
  • /medical and health sciences/health sciences/nutrition

Call for proposal

FP7-KBBE-2008-2B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

WAGENINGEN UNIVERSITY
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 369 489
Administrative Contact
Jos Teunissen

Participants (12)

ID-LELYSTAD, INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID B.V.

Participation ended

Netherlands
EU contribution
€ 88 535
Address
Edelhertweg 15
8219PH Lelystad
Activity type
Research Organisations
Administrative Contact
Sietse-Jan Koopmans (Dr.)
ASG VEEHOUDERIJ BV

Participation ended

Netherlands
EU contribution
€ 270 676
Address
Edelhertweg 15
8219 PH Lelystad
Activity type
Research Organisations
Administrative Contact
Alfons Jansman (Dr.)
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 337 109
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johanna Rule (Ms.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 495 244
Address
Rue De L'universite 147
75338 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Jean-Pierre Delage (Dr.)
OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Germany
EU contribution
€ 276 000
Address
Universitaetsplatz 2
39106 Magdeburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hermann-Josef Rothkötter (Prof.)
ISTITUTO NAZIONALE DI RICERCA PER GLI ALIMENTI E LA NUTRIZIONE
Italy
EU contribution
€ 222 000
Address
Via Ardeatina, 546
00178 Roma
Activity type
Research Organisations
Administrative Contact
Elena Mengheri (Dr.)
NANJING AGRICULTURAL UNIVERSITY
China
EU contribution
€ 117 600
Address
Tongwei Road 6, Weigang
210095 Nanjing
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wei-Yun Zhu (Prof.)
PARCO TECNOLOGICO PADANO S.R.L.
Italy
EU contribution
€ 239 640
Address
Via Einstein - Localita Cascina Codazza
26900 Lodi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gianluca Carenzo (Dr.)
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
EU contribution
€ 102 800
Address
Videnska 1083
142 00 Praha 4
Activity type
Research Organisations
Administrative Contact
Igor Splichal (Dr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 275 418
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sanna-Maija Miettinen (Dr.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 205 200
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Verdiana Bandini (Ms.)
STICHTING WAGENINGEN RESEARCH
Netherlands
EU contribution
€ 270 676
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Research Organisations
Administrative Contact
Alfons Jansman (Dr.)