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Interplay of microbiota and gut function in the developing pig – Innovative avenues towards sustainable animal production

Cel

Low input farming occurs under non-SPF (specific pathogen free) conditions. The European ban on in-feed antibiotics exposes the piglets to a higher microbial environmental pressure. The postnatal priming of piglets with a diverse microbiota may affect the development of the piglet’s host-defense and gut functionality. By reversal, the piglets developing host-defense may affect the development of the gastro-intestinal microbiota. Moreover, this intricate interplay between gut microbiota and its host during the early phases of life is expected to also affect animal health and performance later in life. The gut microbiome is an immensely diverse ecosystem that has co-evolved with its host. Recent research on microbe-host interactions has provided novel insights into the role of commensal intestinal microbes in several physiological processes, i.e. from epithelial barrier development to immune development as well as neurological aspects. Nevertheless, we only start to understand the molecular mechanisms of the host microbe cross-talk. Recent conceptual as well as technological advances have set the stage for the integrated application of a complementary set of high throughput approaches for the comprehensive profiling of GIT microbiota composition and functionality as well as the animal’s intestinal function. In a multidisciplinary consortium, comprising 11 public and private partners from across and beyond Europe with complementary expertise in gut microbiomics, immunology and physiology, and animal genomics and nutrition, INTERPLAY will apply an integrated approach to arrive at a sound understanding of the interaction of early colonization of the intestine and the development of gut function. This knowledge will be exploited for the identification of innovative management strategies that address host genotype as well as nutritional means to provide a framework for sustainable animal production at high food and consumer safety and improved animal health and welfare.

Zaproszenie do składania wniosków

FP7-KBBE-2008-2B
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

WAGENINGEN UNIVERSITY
Wkład UE
€ 369 489,00
Adres
DROEVENDAALSESTEEG 4
6708 PB Wageningen
Niderlandy

Zobacz na mapie

Region
Oost-Nederland Gelderland Veluwe
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Jos Teunissen
Linki
Koszt całkowity
Brak danych

Uczestnicy (12)