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NOVEL SOLUTIONS FOR THE SUSTAINABLE CONTROL OF NEMATODES IN RUMINANTS

Objective

PARASOL focuses on gastro-intestinal nematode parasites of ruminants as they are the greatest threat to animal welfare and production, and since effective contributions can be made within three years. Current conventional methods for worm control involve repeated dosing of whole herds with synthetic anthelmintics but are unsustainable due to the food and environmental residues produced and promote the spread of anthelmintic resistance by failing to leave an untreated parasite refugium.

Effective chemical anthelmintics remain irreplaceable for worm control and their elimination is not practical on animal welfare and economic grounds. We will replace current practice with Targeted Selective Treatments, where only animals showing clinical symptoms or reduced productivity are given drugs. Animals with low worm burdens are symptomless and do not require treatment. We will assess several innovative methods, under various farming conditions, for identifying animals that require treatment, and produce and standardise tests for anthelmintic resistance to ensure that the drugs are effective. We will produce, by the end of the project, clear guidance and protocols for sustainable, low-input, user- and consumer-friendly nematode control.

In order to do this we will:
(1) assess the effect of targeted selective treatments on productivity, animal welfare and the spread of anthelmintic resistance genes under a range of farming conditions;
(2) determine the best methods of identifying animals and herds requiring anthelmintic intervention;
(3) standardise existing in vivo and in vitro tests for detecting anthelmintic resistance and develop new tests for where current ones are inadequate;
(4) optimise the efficacy and bio-availability of anthelmintics by modulating parasite P-glycoprotein detoxification systems; and
(5) communicate with farmers, veterinarians and advisors, to produce and disseminate guidance to ensure good uptake and implementation of the protocols produced.

Call for proposal

FP6-2004-FOOD-3-B
See other projects for this call

Coordinator

UNIVERSITEIT GENT
Address
Sint-pietersnieuwstraat 25
Ghent
Belgium

Participants (16)

UNIVERSITY OF BATH
United Kingdom
Address
Claverton Down
Bath
UNIVERSITY OF BRISTOL
United Kingdom
Address
Senate House, Tyndall Avenue
Bristol
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
Address
Buenteweg 2
Hannover
SVERIGES LANTBRUKSUNIVERSITET
Sweden
Address
Arrheniusplan 2C
Uppsala
MOREDUN RESEARCH INSTITUTE
United Kingdom
Address
Pentland Science Park, Bush Loan, Penicuik
Edinburgh
PARASITOLOGICAL INSTITUTE, SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
Hlinkova 3
Kosice
UNIVERSITY OF PRETORIA
South Africa
Address
Lynnwood Road
None Pretoria
INSTITUT AGRONOMIQUE ET VÉTÉRINAIRE HASSAN II
Morocco
Address
Madinat Al Irfane
Rabat
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
Address
Administration Building - University Campus
Thessaloniki
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
Address
Via Della Veterinaria, 1
Napoli
INNOVIS LTD.
United Kingdom
Address
Peithyll Centre, Capel Dewi
Aberystwyth
NATIONAL WOOL GROWERS' ASSOCIATION
South Africa
Address
41A Pickering Street, Newton Park
34291 Port Elizabeth
SVANOVA BIOTECH AB
Sweden
Address
Uppsala Science Park
Uppsala
PLANTAMEDIUM GMBH
Germany
Address
Everswinkeler Str. 7
20 01 24 Warendorf
FRAENZ & JAEGER GMBH
Germany
Address
Schurzelter Strasse 27
Aachen
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Rue De L'université 147
Paris